2. Gene
  3. CUL2 - cullin 2 Gene

CUL2 - cullin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：卡林 2

种属: Homo sapiens

基因 ID: 8453 | 基因类型: protein coding

关于 CUL2

Cytogenetic location: 10p11.21 Genomic coordinates (GRCh38): 10:35,008,551-35,127,006 (from NCBI)

This gene has 49 transcripts (splice variants), 226 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 12.7), brain (RPKM 7.3) and 25 other tissues.

功能概要

启用泛素蛋白连接酶结合活性。预计参与 SCF 依赖的蛋白酶体泛素依赖性蛋白质分解代谢过程和蛋白质泛素化。预计在蛋白质分解代谢过程的上游或内部起作用。位于核质中。 Cul2-RING 泛素连接酶复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables ubiquitin protein Ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within protein catabolic process. Located in nucleoplasm. Part of Cul2-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

CUL2 基因产物(6)

mRNA Protein Name
NM_001198777.2 NP_001185706.1 cullin-2 isoform c
NM_001198778.2 NP_001185707.1 cullin-2 isoform a
NM_001198779.1 NP_001185708.1 cullin-2 isoform b
NM_001324375.2 NP_001311304.1 cullin-2 isoform d
NM_001324376.2 NP_001311305.1 cullin-2 isoform e
NM_003591.4 NP_003582.2 cullin-2 isoform c
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12504026 GOA
enables ubiquitin ligase complex scaffold activity IDA
IDA: 通过直接分析推断
29779948 GOA
enables ubiquitin protein ligase binding IDA
IDA: 通过直接分析推断
17636018 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway IDA
IDA: 通过直接分析推断
29779948 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul2-RING ubiquitin ligase complex IDA
IDA: 通过直接分析推断
17636018 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CUL2 蛋白结构

Cullin

Cullin: Cullin family (14 - 645)

Cullin_Nedd8

Cullin_Nedd8: Cullin protein neddylation domain (672 - 736)

  • 0
  • 200
  • 400
  • 600
  • 745 a.a.
蛋白主名 其他名称

cullin-2

CUL-2

CUL2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CUL2 Q13617 KLHDC3 Homo sapiens Q9BQ90
TAP
21145461
种属内
CUL2 Q13617 KLHDC3 Homo sapiens Q9BQ90
Anti Tag CoIP
33961781
种属内
CUL2 Q13617 COMMD1 Homo sapiens Q8N668
Pull Down
23563313
种属内
CUL2 Q13617 COMMD1 Homo sapiens Q8N668
Anti Bait CoIP
17183367
种属内
CUL2 Q13617 ZYG11B Homo sapiens Q9C0D3
TAP
21145461
种属内
CUL2 Q13617 ZYG11B Homo sapiens Q9C0D3
Anti Tag CoIP
33961781
种属内
CUL2 Q13617 UBXN7 Homo sapiens O94888
TAP
21145461
种属内
CUL2 Q13617 UBXN7 Homo sapiens O94888
Anti Tag CoIP
22466964
种属内
CUL2 Q13617 LRRC14 Homo sapiens Q15048
TAP
21145461
种属内
CUL2 Q13617 LRRC14 Homo sapiens Q15048
Anti Tag CoIP
33961781
种属内
CUL2 Q13617 ELOC Homo sapiens Q15369
Anti Tag CoIP
15601820
种属内
CUL2 Q13617 ELOC Homo sapiens Q15369
Pull Down
23563313
种属内
CUL2 Q13617 ELOC Homo sapiens Q15369
Pull Down
19327355
种属内
CUL2 Q13617 ELOC Homo sapiens Q15369
TAP
21145461
种属内
CUL2 Q13617 VHL Homo sapiens P40337
GMS
25661653
种属内
CUL2 Q13617 VHL Homo sapiens P40337
TAP
21145461
种属内
CUL2 Q13617 VHL Homo sapiens P40337
Anti Tag CoIP
33961781
种属内
CUL2 Q13617 VHL Homo sapiens P40337
Anti Tag CoIP
18323857
种属内
CUL2 Q13617 VHL Homo sapiens P40337
Anti Tag CoIP
15601820
种属内
CUL2 Q13617 VHL Homo sapiens P40337
Ion Exchange Chrom
25661653
种属内
CUL2 Q13617 VHL Homo sapiens P40337
X-Ray Diffraction
25661653
种属内
CUL2 Q13617 HSP90AB1 Homo sapiens P08238
TAP
21145461
种属内
CUL2 Q13617 RBX1 Homo sapiens P62877
Pull Down
19327355
种属内
CUL2 Q13617 RBX1 Homo sapiens P62877
Anti Tag CoIP
15601820
种属内
CUL2 Q13617 CAND1 Homo sapiens Q86VP6
Anti Bait CoIP
12504026
种属间
CUL2 Q13617 vif Human immunodeficiency virus P12504
Pull Down
22190034
种属间: 跨种属相互作用 种属内: 同种属相互作用

CUL2 抗体

目录号 产品名 应用 反应物种
HY-P82457 Cullin 2 Antibody (YA2202) WB, ICC/IF, IP, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Moyamoya Angiopathy
External Ear Squamous Cell Carcinoma

Epidermoid Carcinoma Of The External Ear

Squamous Cell Carcinoma Of External Ear
Von Hippel-Lindau Syndrome

Von Hippel-Lindau Disease

Vhl

Vhl Syndrome

VHLS

Von Hippel-Lindau Syndrome, Modifier Of

Hippel Lindau Syndrome

Angiomatosis Retinae

Cerebelloretinal Angiomatosis, Familial

Hippel-Lindau Disease

Familial Cerebelloretinal Angiomatosis

Lindau Disease

VHLD
External Ear Carcinoma

Carcinoma Of External Ear

Carcinoma Of The External Ear
Retinal Hemangioblastoma

Capillary Hemangioma Of Retina
Familial Renal Papillary Carcinoma

Hereditary Papillary Renal Carcinoma

Papillary Renal Cancer Hereditary
Leiomyoma Cutis

Cutaneous Leiomyoma

Leiomyoma Of The Skin
Dermis Tumor

Dermis Tumour

Neoplasm Of Dermis

Tumor Of Dermis

Tumour Of Dermis
Hereditary Renal Cell Carcinoma
Kidney Cancer

Renal Cancer

Renal Carcinoma

Kidney Neoplasm

Malignant Neoplasm Of Kidney Except Pelvis

Malignant Tumour Of Kidney

Kidney Neoplasms

Cancer, Kidney

Cancer, Renal

Malignant Neoplasm Of Kidney

Renal Cell Carcinoma
Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant
Erythrocytosis, Familial, 2

Chuvash Polycythemia

ECYT2

Familial Erythrocytosis 2

Autosomal Recessive Benign Erythrocytosis

Polycythemia, Vhl-Dependent

Chuvash Erythromatosis

Chuvash Type Polycythemia

Chuvash Erythrocytosis

Von Hippel-Lindau-Dependent Polycythemia

Polycythemia Chuvash Type

Vhl-Dependent Polycythemia

Erythrocytosis, Familial, Type 2
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Cardiovascular Organ Benign Neoplasm
Three M Syndrome 1

3-M Syndrome

Yakut Short Stature Syndrome

3m Syndrome

Le Merrer Syndrome

Dolichospondylic Dysplasia

Gloomy Face Syndrome

Three M Syndrome

3M1

3m Syndrome 1

Miller-Mckusick-Malvaux Syndrome

3-Msbn

Three-M Slender-Boned Nanism

Miller-Mckusick-Malvaux-Syndrome

3-M Syndrome 1

3m Syndrome-1

3m Syndrome, Type 1

Dwarfism

Dwarfism Tall Vertebrae
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03360 CUL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CUL2 VGNC VGNC:71566
Rattus norvegicus CUL2 RGD RGD:1310644
Canis familiaris CUL2 VGNC VGNC:39729
Mus musculus CUL2 MGD MGI:1918995
Bos taurus CUL2 VGNC VGNC:27830
Felis catus CUL2 VGNC VGNC:61283
Others CUL2 NCBI
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