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  2. ZYG11B - zyg-11 family member B, cell cycle regulator Gene

ZYG11B - zyg-11 family member B, cell cycle regulator Gene

中文名称:zyg-11 家族成员 B,细胞周期调节因子

种属: Homo sapiens

同用名: ZYG11

基因 ID: 79699 | 基因类型: protein coding

关于 ZYG11B

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:52,726,453-52,827,336 (from NCBI)

This gene has 2 transcripts (splice variants), 271 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 12.1), thyroid (RPKM 8.7) and 25 other tissues.

功能概要

参与蛋白酶体泛素依赖性蛋白质分解代谢过程的正调控和错误折叠或不完全合成蛋白质的蛋白质质量控制。 Cul2-RING 泛素连接酶复合物的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Part of Cul2-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

ZYG11B 基因产物(1)

mRNA Protein Name
NM_024646.3 NP_078922.1 protein zyg-11 homolog B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17304241 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul2-RING ubiquitin ligase complex IDA
IDA: 通过直接分析推断
31273098 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

protein zyg-11 homolog B

zyg-11 homolog B

ZYG11B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZYG11B Q9C0D3 CUL2 Homo sapiens Q13617
Anti Tag CoIP
17304241
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Craniofacial Microsomia

Goldenhar Syndrome

Hemifacial Microsomia

Oculoauriculovertebral Spectrum

Oavs

Oculo-Auriculo-Vertebral Spectrum

CFM

Oav Dysplasia

Facioauriculovertebral Sequence

Fav Sequence

First And Second Branchial Arch Syndrome

Otomandibular Dysostosis

Hfm

Oculoauriculovertebral Dysplasia

Facio-Auriculo-Vertebral Spectrum

Facioauriculovertebral Dysplasia

Oculo-Auriculo-Vertebral Dysplasia

First Arch Syndrome

Oav Dysplasia

Goldenhar Disease

Expanded Spectrum Hemifacial Microsomia

Expanded Spectrum Of Hemifacial Microsomia

Oculoauriculovertebral Syndrome

Oavd

Asymmetric Hypoplasia Of Facial Structures

Auriculobranchiogenic Dysplasia

Fav

First And Second Pharyngeal Arch Syndromes

Goldenhar-Gorlin Syndrome

Lateral Facial Dysplasia

Oav Complex

Oral-Mandibular-Auricular Syndrome

Unilateral Intrauterine Facial Necrosis

Unilateral Mandibulofacial Dysostosis

Oav Spectrum

Oculoauricular Vertebral Dysplasia

Microsomia, Hemifacial

Goldenhar Syndrome With Ipsilateral Radial Defect

Cardiomyopathy, Familial Hypertrophic, 26

Hypertrophic Cardiomyopathy 26

CMH26

Cardiomyopathy, Familial Restrictive 5

Cardiomyopathy, Familial Restrictive, 5

Cardiomyopathy Familial Hypertrophic 26

Cardiomyopathy, Familial Hypertrophic 26

RCM5

Noonan Syndrome 12

NS12

Branchiootic Syndrome

Bo Syndrome

Branchiootic Dysplasia

Bor

Bo Syndrome 1

Bos1

Branchiootic Syndrome 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ZYG11B VGNC VGNC:100197
Felis catus ZYG11B VGNC VGNC:67393
Bos taurus ZYG11B VGNC VGNC:37394
Mus musculus ZYG11B MGD MGI:2685277
Canis familiaris ZYG11B VGNC VGNC:48869
Rattus norvegicus ZYG11B RGD RGD:1307814