2. Gene
  3. ELOC - elongin C Gene

ELOC - elongin C Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：伸长素 C

种属: Homo sapiens

同用名: SIII; TCEB1

基因 ID: 6921 | 基因类型: protein coding

关于 ELOC

Cytogenetic location: 8q21.11 Genomic coordinates (GRCh38): 8:73,945,119-73,972,287 (from NCBI)

This gene has 15 transcripts (splice variants) and 246 orthologues. Ubiquitous expression in testis (RPKM 15.6), brain (RPKM 14.4) and 25 other tissues.

功能概要

该基因编码蛋白 elongin C，它是转录因子 B (SIII) 复合物的一个亚基。 SIII 复合物由延长蛋白 A/A2、B 和 C 组成。它通过抑制聚合酶在转录单位内许多位点的瞬时暂停来激活 RNA 聚合酶 II 的延长。 Elongin A 作为 SIII 复合物的转录活性成分起作用，而 Elongin B 和 C 是调节亚基。 Elongin A2 在睾丸中特异性表达，能够与 elongin B 和 C 形成稳定的复合物。von Hippel-Lindau 肿瘤抑制蛋白与 elongin B 和 C 结合，从而抑制转录延伸。已经鉴定出编码两种不同同种型的多个选择性剪接的转录本变体。[RefSeq 提供，2011 年 3 月]

This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

ELOC 基因产物(9)

mRNA Protein Name
NM_001204857.2 NP_001191786.1 elongin-C isoform a
NM_001204858.2 NP_001191787.1 elongin-C isoform a
NM_001204859.2 NP_001191788.1 elongin-C isoform a
NM_001204860.2 NP_001191789.1 elongin-C isoform a
NM_001204861.2 NP_001191790.1 elongin-C isoform a
NM_001204862.2 NP_001191791.1 elongin-C isoform a
NM_001204863.2 NP_001191792.1 elongin-C isoform b
NM_001204864.2 NP_001191793.1 elongin-C isoform b
NM_005648.4 NP_005639.1 elongin-C isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10205047 GOA
enables transcription corepressor binding IPI
IPI: 通过物理相互作用推断
7660122 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
30166453 GOA
involved in target-directed miRNA degradation IMP
IMP: 通过突变表型推断
33184237 GOA
involved in transcription initiation at RNA polymerase II promoter IDA
IDA: 通过直接分析推断
7660122 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul5-RING ubiquitin ligase complex IDA
IDA: 通过直接分析推断
21980433 GOA
part of elongin complex IDA
IDA: 通过直接分析推断
7660122 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ELOC 蛋白结构

Skp1_POZ

Skp1_POZ: Skp1 family, tetramerisation domain (17 - 79)

  • 0
  • 100
  • 112 a.a.
蛋白主名 其他名称

elongin-C

RNA polymerase II transcription factor SIII subunit C

ELOC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ELOC Q15369 METTL21C Homo sapiens Q5VZV1
Validated Y2H
25416956
Intra ELOC Q15369 METTL21C Homo sapiens Q5VZV1
Validated Y2H
32296183
Intra ELOC Q15369 METTL21C Homo sapiens Q5VZV1
Y2H Array
32296183
Intra ELOC Q15369 METTL21C Homo sapiens Q5VZV1
Y2H Prey Pooling
25416956
Intra ELOC Q15369 METTL21C Homo sapiens Q5VZV1
Y2H Prey Pooling
32296183
Intra ELOC Q15369 METTL21C Homo sapiens Q5VZV1
Y2H Array
31515488
Cross ELOC Q15369 ORF10 SARS-CoV-2 A0A663DJA2
Y2H Array
36217030
Intra ELOC Q15369 ELOB Homo sapiens Q15370
Validated Y2H
32296183
Intra ELOC Q15369 ELOB Homo sapiens Q15370
Y2H Array
25416956
Intra ELOC Q15369 ELOB Homo sapiens Q15370
Y2H Array
20211142
Intra ELOC Q15369 ELOB Homo sapiens Q15370
Y2H Array
32296183
Intra ELOC Q15369 ELOB Homo sapiens Q15370
Y2H
21516116
Intra ELOC Q15369 ELOB Homo sapiens Q15370
Y2H Pooling
16189514
Intra ELOC Q15369 ELOB Homo sapiens Q15370
Y2H Prey Pooling
25416956
Intra ELOC Q15369 ELOB Homo sapiens Q15370
Validated Y2H
25416956
Intra ELOC Q15369 ELOB Homo sapiens Q15370
Y2H Prey Pooling
32296183
Intra ELOC Q15369 PRAME Homo sapiens P78395
Y2H
23460923
Intra ELOC Q15369 PRAME Homo sapiens P78395
Confocal
23460923
Intra ELOC Q15369 MED8 Homo sapiens Q96G25
Y2H
12149480
Intra ELOC Q15369 CUL2 Homo sapiens Q13617
Pull Down
17183367
Intra ELOC Q15369 SOCS2 Homo sapiens O14508
Y2H Array
16643902
Intra ELOC Q15369 ASB9 Homo sapiens Q96DX5
Y2H Array
20211142
Intra ELOC Q15369 SOCS1 Homo sapiens O15524
Pull Down
17183367
Cross ELOC Q15369 vif Human immunodeficiency virus P12504
Pull Down
22190034
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma

Hereditary Papillary Renal Cell Carcinoma

Papillary Renal Cell Carcinoma, Sporadic

Papillary Renal Cell Adenocarcinoma

RCCP

RCCP1

Renal Cell Carcinoma, Papillary

Renal Cell Carcinoma, Papillary, 1, Familial And Somatic

Chromophil Carcinoma Of Kidney

Papillary Kidney Carcinoma

Sporadic Papillary Renal Cell Carcinoma

Chromophil Renal Cell Carcinoma

Papillary Renal Carcinoma, Malignant -

Papillary Renal Cell Carcinoma, Bilateral -

Papillary Renal Cell Carcinoma, Familial -

Papillary Renal Cell Carcinoma, Multiple -

Papillary Renal Cell Carcinoma, Sporadic -

Renal Adenocarcinoma

Chromophil Rcc

Hprcc

Renal Cell Carcinoma Papillary

Chromophilic Renal Cell Carcinoma

Prcc

Carcinoma, Renal Cell, Papillary, Type 1

Type 1 Papillary Renal Cell Carcinoma

Renal Cell Carcinoma

Hereditary Papillary Renal Carcinoma
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Retinal Hemangioblastoma

Capillary Hemangioma Of Retina
Molluscum Contagiosum

Water Warts

Molluscum Verrucosum
Central Nervous System Hemangioma

Hemangioma Of Cns

Hemangioma Of The Central Nervous System
Erythrocytosis, Familial, 4

ECYT4

Familial Erythrocytosis 4

Erythrocytosis, Familial, Type 4
Familial Renal Papillary Carcinoma

Hereditary Papillary Renal Carcinoma

Papillary Renal Cancer Hereditary
Polycythemia

Erythrocythemia

Polycythemia Vera

Polycythaemia Due To High Altitude
Leiomyoma Cutis

Cutaneous Leiomyoma

Leiomyoma Of The Skin
Dermis Tumor

Dermis Tumour

Neoplasm Of Dermis

Tumor Of Dermis

Tumour Of Dermis
Erythrocytosis, Familial, 2

Chuvash Polycythemia

ECYT2

Familial Erythrocytosis 2

Autosomal Recessive Benign Erythrocytosis

Polycythemia, Vhl-Dependent

Chuvash Erythromatosis

Chuvash Type Polycythemia

Chuvash Erythrocytosis

Von Hippel-Lindau-Dependent Polycythemia

Polycythemia Chuvash Type

Vhl-Dependent Polycythemia

Erythrocytosis, Familial, Type 2
Inhibited Male Orgasm

Male Orgasmic Disorder

Psychosexual Dysfunction With Male Orgasmic Disorder
Primary Polycythemia

Familial Erythrocytosis

Familiar Polycythemia

Benign Familial Polycythemia

Congenital Erythrocytosis

Familial Polycythemia

Hereditary Erythrocytosis

Primary Familial Polycythemia

Erythrocytosis, Familial

Polycythemia Vera

Primary Familial Polycythaemia

Primary Inherited Polycythaemia
Hereditary Renal Cell Carcinoma
Von Hippel-Lindau Syndrome

Von Hippel-Lindau Disease

Vhl

Vhl Syndrome

VHLS

Von Hippel-Lindau Syndrome, Modifier Of

Hippel Lindau Syndrome

Angiomatosis Retinae

Cerebelloretinal Angiomatosis, Familial

Hippel-Lindau Disease

Familial Cerebelloretinal Angiomatosis

Lindau Disease

VHLD
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Cardiovascular Organ Benign Neoplasm
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04319 ELOC Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ELOC RGD RGD:620658
Macaca mulatta ELOC VGNC VGNC:82139
Mus musculus ELOC MGD MGI:1915173
Bos taurus ELOC VGNC VGNC:28445
Canis familiaris ELOC VGNC VGNC:40317
Others ELOC NCBI
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