2. Gene
  3. ASB9 - ankyrin repeat and SOCS box containing 9 Gene

ASB9 - ankyrin repeat and SOCS box containing 9 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含锚蛋白重复和 SOCS 框 9

种属: Homo sapiens

基因 ID: 140462 | 基因类型: protein coding

关于 ASB9

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:15,243,987-15,270,467 (from NCBI)

This gene has 9 transcripts (splice variants), 129 orthologues and 2 paralogues. Biased expression in testis (RPKM 16.8), kidney (RPKM 5.8) and 8 other tissues.

功能概要

该基因编码锚蛋白重复序列和细胞因子信号转导抑制蛋白 (SOCS) 盒蛋白家族的成员。该家族的成员可以通过其 SOCS 盒结构域与 elongin BC 衔接子复合物相互作用，并进一步与 cullin 和环盒蛋白复合以形成 E3 泛素连接酶复合物。它们可能起到介导 E3 泛素连接酶底物识别的作用。已在 15 号染色体上鉴定出该基因的转录假基因。已发现该基因编码不同亚型的多个转录变体。[RefSeq 提供，2009 年 12 月]

This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin Ligase complexes. They may function to mediate the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

ASB9 基因产物(4)

mRNA Protein Name
NM_001031739.3 NP_001026909.1 ankyrin repeat and SOCS box protein 9 isoform 1
NM_001168530.2 NP_001162002.1 ankyrin repeat and SOCS box protein 9 isoform 3
NM_001168531.2 NP_001162003.1 ankyrin repeat and SOCS box protein 9 isoform 2
NM_024087.3 NP_076992.1 ankyrin repeat and SOCS box protein 9 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: 通过直接分析推断
25654263 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within positive regulation of protein catabolic process IDA
IDA: 通过直接分析推断
17148442 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
25654263 GOA
acts upstream of or within protein ubiquitination IDA
IDA: 通过直接分析推断
17148442 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul5-RING ubiquitin ligase complex IDA
IDA: 通过直接分析推断
23837592 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ASB9 蛋白结构

Ank_4

Ank_4: Ankyrin repeats (many copies) (37 - 89)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (106 - 195)

Ank

Ank: Ankyrin repeat (200 - 229)

SOCS_box

SOCS_box: SOCS box (255 - 293)

  • 0
  • 100
  • 200
  • 294 a.a.
蛋白主名 其他名称

ankyrin repeat and SOCS box protein 9

ASB-9

ASB9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ASB9 Q96DX5 CKMT1A Homo sapiens P12532
Anti Tag CoIP
33961781
Intra ASB9 Q96DX5 CKMT1A Homo sapiens P12532
Y2H Array
32296183
Intra ASB9 Q96DX5 CKMT1A Homo sapiens P12532
Y2H Prey Pooling
32296183
Intra ASB9 Q96DX5 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra ASB9 Q96DX5 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra ASB9 Q96DX5 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra ASB9 Q96DX5 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra ASB9 Q96DX5 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra ASB9 Q96DX5 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra ASB9 Q96DX5 ELOC Homo sapiens Q15369
Anti Tag CoIP
33961781
Intra ASB9 Q96DX5 ELOC Homo sapiens Q15369
Anti Tag CoIP
28514442
Intra ASB9 Q96DX5 CKB Homo sapiens P12277
Anti Tag CoIP
33961781
Intra ASB9 Q96DX5 CKB Homo sapiens P12277
Anti Tag CoIP
28514442
Intra ASB9 Q96DX5 CKB Homo sapiens P12277
Y2H Prey Pooling
32296183
Intra ASB9 Q96DX5 CKB Homo sapiens P12277
Y2H Array
19060904
Intra ASB9 Q96DX5 CKB Homo sapiens P12277
Y2H Array
25416956
Intra ASB9 Q96DX5 CKB Homo sapiens P12277
Y2H Pooling
19060904
Intra ASB9 Q96DX5 CKB Homo sapiens P12277
Y2H Array
32296183
Intra ASB9 Q96DX5 EXOSC1 Homo sapiens Q9Y3B2
Validated Y2H
32296183
Intra ASB9 Q96DX5 SMN1 Homo sapiens Q16637
Validated Y2H
32814053
Intra ASB9 Q96DX5 SMN1 Homo sapiens Q16637
Y2H Array
32814053
Intra ASB9 Q96DX5 SMN1 Homo sapiens Q16637
Y2H Pooling
32814053
Intra ASB9 Q96DX5 CKM Homo sapiens P06732
Y2H Array
25416956
Intra ASB9 Q96DX5 CKM Homo sapiens P06732
Anti Tag CoIP
33961781
Intra ASB9 Q96DX5 CKM Homo sapiens P06732
Y2H Prey Pooling
32296183
Intra ASB9 Q96DX5 CKM Homo sapiens P06732
Anti Tag CoIP
28514442
Intra ASB9 Q96DX5 CKM Homo sapiens P06732
Y2H
21516116
Intra ASB9 Q96DX5 CKM Homo sapiens P06732
Validated Y2H
25416956
Intra ASB9 Q96DX5 CKM Homo sapiens P06732
Y2H Array
32296183
Intra ASB9 Q96DX5 HIF1AN Homo sapiens Q9NWT6
Y2H Array
31515488
Intra ASB9 Q96DX5 HIF1AN Homo sapiens Q9NWT6
Y2H Pooling
19060904
Intra ASB9 Q96DX5 HIF1AN Homo sapiens Q9NWT6
Anti Tag CoIP
33961781
Intra ASB9 Q96DX5 HIF1AN Homo sapiens Q9NWT6
Anti Tag CoIP
28514442
Intra ASB9 Q96DX5 HIF1AN Homo sapiens Q9NWT6
Y2H Array
19060904
Intra ASB9 Q96DX5 CRK Homo sapiens P46108
Lumier
25814554
Intra ASB9 Q96DX5 CRK Homo sapiens P46108
Y2H Array
25814554
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Fanconi Anemia, Complementation Group B

Fanconi Anemia Complementation Group B

FANCB

Facb

Fa2

Fanconi Pancytopenia Type 2

Fanconi Pancytopenia, Type 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01074 ASB9 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ASB9 VGNC VGNC:38169
Bos taurus ASB9 VGNC VGNC:26202
Felis catus ASB9 VGNC VGNC:59965
Rattus norvegicus ASB9 RGD RGD:1560537
Mus musculus ASB9 MGD MGI:1916549
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z