2. Gene
  3. CKM - creatine kinase, M-type Gene

CKM - creatine kinase, M-type Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肌酸激酶，M 型

种属: Homo sapiens

同用名: CKMM; M-CK; CPK-M

基因 ID: 1158 | 基因类型: protein coding

关于 CKM

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,306,413-45,322,875 (from NCBI)

This gene has 1 transcript (splice variant), 282 orthologues and 4 paralogues. Biased expression in heart (RPKM 751.9), esophagus (RPKM 219.5) and 1 other tissue.

功能概要

该基因编码的蛋白质是一种参与能量稳态的细胞质酶，是心肌梗死的重要血清标志物。编码的蛋白质可逆地催化磷酸盐在 ATP 和各种磷原 (如磷酸肌酸) 之间的转移。它在横纹肌和其他组织中充当同二聚体，在心脏中充当具有相似脑同工酶的异二聚体。编码的蛋白质是 ATP:胍基磷酸转移酶蛋白质家族的成员。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a cytoplasmic Enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]

CKM 基因产物(1)

mRNA Protein Name
NM_001824.5 NP_001815.2 creatine kinase M-type
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12972258 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CKM 蛋白结构

ATP-gua_PtransN

ATP-gua_PtransN: ATP:guanido phosphotransferase, N-terminal domain (21 - 100)

ATP-gua_Ptrans

ATP-gua_Ptrans: ATP:guanido phosphotransferase, C-terminal catalytic domain (121 - 367)

  • 0
  • 100
  • 200
  • 300
  • 381 a.a.
蛋白主名 其他名称

creatine kinase M-type

creatine kinase M chain

重组 CKM 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7827 Creatine kinase M-type/CKM Protein, Human (HEK293, His) AAP35439.1 (M1-K381) ≥95%
HY-P75340 Creatine kinase M-type/CKM Protein, Human (His) AAH07462.1 (M1-K381) ≥95%

关联疾病

疾病名称 别名
Kidney Leiomyosarcoma

Leiomyosarcoma Of Kidney
Hemophilia B

Christmas Disease

Factor Ix Deficiency

F9 Deficiency

HEMB

Plasma Thromboplastin Component Deficiency

Congenital Factor Ix Deficiency

Mild Hemophilia B

Severe Hemophilia B

Congenital Factor Ix Disorder

Deficiency, Functional Factor Ix

Hem B

Mild Congenital F9 Deficiency

Mild Congenital Factor Ix Deficiency

Moderate Hemophilia B

Moderate Congenital F9 Deficiency

Moderate Congenital Factor Ix Deficiency

Severe Congenital F9 Deficiency

Severe Congenital Factor Ix Deficiency

Bleeding Disorder In Hemophilia B Carriers

Congenital F9 Deficiency

Recessive X-Linked Hemophilia B
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1
Myotonic Dystrophy 1

Myotonic Dystrophy

Dystrophia Myotonica

Steinert Disease

Myotonic Dystrophy Type 1

Myotonia Atrophica

DM1

Congenital Myotonic Dystrophy

Myotonia Dystrophica

Steinert Myotonic Dystrophy

Dystrophia Myotonica 1

Dm

Steinert'S Disease

Steinert Myotonic Dystrophy Syndrome

Myotonic Dystrophy Of Steinert

Dystrophia Myotonica Type 1

Myotonic Dystrophy Congenital

Dystrophy, Myotonic, Type 1

Dm - [Dystrophia Myotonica]

Myotonic Muscular Dystrophy
Mcleod Syndrome

Mcleod Neuroacanthocytosis Syndrome

MLS

X-Linked Mcleod Syndrome

Mcleod Phenotype

Neuroacanthocytosis, Mcleod Type

Mcleod Syndrome With Or Without Chronic Granulomatous Disease

MCLDS

Mcleod Type Neuroacanthocytosis

Mcleod Syndrome With Chronic Granulomatous Disease

Neuroacanthocytosis Mcleod Type

Blood Group Deletion Syndrome
Acute Myocardial Infarction

Cardiac Attack

Heart Attack
Muscular Dystrophy

Muscular Dystrophies

Congenital Md

Congenital Muscular Dystrophy

Cmd

Mdc

Dystrophy, Muscular

Gower'S Muscular Dystrophy

Progressive Musclular Dystrophy

Pseudohypertrophic Atrophy

Pseudohypertrophic Muscle Paralysis

Pseudohypertrophic Muscular Atrophy

Pseudohypertrophic Muscular Dystrophy

Pseudohypertrophic Paralysis

Pseudomuscular Hypertrophy
Barbiturate Dependence
Epidermolysis Bullosa Simplex 5b, With Muscular Dystrophy

Epidermolysis Bullosa Simplex With Muscular Dystrophy

Md-Ebs

Epidermolysis Bullosa Simplex And Limb-Girdle Muscular Dystrophy

EBS5B

Ebsmd

Mdebs

Limb-Girdle Muscular Dystrophy With Epidermolysis Bullosa Simplex

Ebs-Md

Epidermolysa Bullosa Simplex And Limb Girdle Muscular Dystrophy

Epidermolysa Bullosa Simplex With Muscular Dystrophy

Epidermolysis Bullosa Simplex - Limb Girdle Muscular Dystrophy

Ebs With Muscular Dystrophy

Muscular Dystrophy With Epidermolysis Bullosa Simplex

Epidermolysa Bullosa Simplex, With Muscular Dystrophy
Gastroenteritis

Cholera Morbus

Infectious Colitis, Enteritis And Gastroenteritis

Enteritis Due To Astrovirus

Rotaviral Gastroenteritis

Viral Gastroenteritis Due To Rotavirus
Glycogen Storage Disease

Glycogenosis

Glycogenoses

Gsd

Storage Disease, Glycogen

Gsd - [Glycogen Storage Disease]

Glycogen Thesaurismosis

Diffuse Glycogenosis

Generalised Glycogen Storage Disease

Generalised Glycogenosis

Generalised Glycogen Storage Disease Of Infants

Glycogen Synthase Deficiency
Prostate Rhabdomyosarcoma

Rhabdomyosarcoma Of The Prostate
Muscular Dystrophy, Duchenne Type

Duchenne Muscular Dystrophy

DMD

Muscular Dystrophy, Duchenne

Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type

Severe Dystrophinopathy, Duchenne Type

Muscular Dystrophy Duchenne

Dystrophy, Muscular, Duchenne Type

Benign Duchenne Muscular Dystrophy

Duchenne Motor Neuron Disease

Duchenne Type Dystrophy

Duchenne-Griesinger Disease
Myopathy

Muscular Diseases

Myopathies
Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02738 CKM Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CKM VGNC VGNC:27385
Macaca mulatta CKM VGNC VGNC:71230
Felis catus CKM VGNC VGNC:60914
Mus musculus CKM MGD MGI:88413
Rattus norvegicus CKM RGD RGD:2358
Canis familiaris CKM VGNC VGNC:39291
Others CKM NCBI
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