Creatine kinase M-type/CKM 蛋白, Human (HEK293, His)

KCRM is a cytoplasmic creatine kinase isoenzyme responsible for participating in energy transduction and maintaining energy homeostasis. KCRM reversibly catalyzes phosphate transfer between ATP and various phosphogens (e.g., creatine phosphate) and is an important serum marker of myocardial infarction. Creatine kinase M-type/CKM Protein, Human (HEK293, His) is the recombinant human-derived Creatine kinase M-type/CKM protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Creatine kinase M-type/CKM Protein, Human (HEK293, His) is 381 a.a., with molecular weight of ~46.0 kDa.

KCRM 是一种细胞质肌酸激酶同工酶，可逆地催化 ATP 和各种磷原（例如磷酸肌酸）之间的磷酸盐转移。KCRM 在能量需求较大且波动的组织（例如骨骼肌、心脏、大脑和精子）中，参与能量转导和能量稳态，是心肌梗塞的重要血清标志物。KCRM 在横纹肌和其他组织中充当同二聚体，并在心脏中充当具有类似脑同工酶的异二聚体。骨骼肌作为重要的分泌器官，在 2 型糖尿病（T2DM）骨骼肌组织中差异分泌裂解的 KCRM 肽。KCRM 发生自然发生的突变可能导致具有活性血清肌酸激酶的个体对 Tenofovir (HY-13910) 暴露前预防 (PrEP) HIV 没有反应。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

HEK293

C-6*His

AAP35439.1 (M1-K381)

1158  [NCBI]

MPFGNTHNKFKLNYKPEEEYPDLSKHNNHMAKVLTLELYKKLRDKETPSGFTVDDVIQTGVDNPGHPFIMTVGCVAGDEESYEVFKELFDPIISDRHGGYKPTDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEKEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNQHLGYVLTCPSNLGTGLRGGVHVKLAHLSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVFDVSNADRLGSSEVEQVQLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK

Approximately 46.0 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl,150 mM NaCl, 10% Glycerol, pH7.5.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.