2. Gene
  3. ELOB - elongin B Gene

ELOB - elongin B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：伸长素 B

种属: Homo sapiens

同用名: SIII; TCEB2

基因 ID: 6923 | 基因类型: protein coding

关于 ELOB

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,771,414-2,777,280 (from NCBI)

This gene has 8 transcripts (splice variants) and 281 orthologues. Ubiquitous expression in testis (RPKM 67.4), adrenal (RPKM 41.2) and 25 other tissues.

功能概要

该基因编码蛋白 elongin B，它是转录因子 B (SIII) 复合物的一个亚基。 SIII 复合物由延长蛋白 A/A2、B 和 C 组成。它通过抑制聚合酶在转录单位内许多位点的瞬时暂停来激活 RNA 聚合酶 II 的延长。 Elongin A 作为 SIII 复合物的转录活性成分起作用，而 Elongin B 和 C 是调节亚基。 Elongin A2 在睾丸中特异性表达，能够与 elongin B 和 C 形成稳定的复合物。von Hippel-Lindau 肿瘤抑制蛋白与 elongin B 和 C 结合，从而抑制转录延伸。已针对该基因描述了编码不同同种型的两种可变剪接转录物变体。已在 11 号和 13 号染色体上鉴定出假基因。[RefSeq 提供，2008 年 8 月]

This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]

ELOB 基因产物(2)

mRNA Protein Name
NM_007108.4 NP_009039.1 elongin-B isoform a
NM_207013.3 NP_996896.1 elongin-B isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10205047 GOA
enables transcription corepressor binding IPI
IPI: 通过物理相互作用推断
7660122 GOA
enables ubiquitin protein ligase binding IDA
IDA: 通过直接分析推断
17636018 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in target-directed miRNA degradation IMP
IMP: 通过突变表型推断
33184237 GOA
involved in transcription initiation at RNA polymerase II promoter IDA
IDA: 通过直接分析推断
7660122 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul2-RING ubiquitin ligase complex IDA
IDA: 通过直接分析推断
17636018 GOA
part of Cul5-RING ubiquitin ligase complex IDA
IDA: 通过直接分析推断
17636018 GOA
part of elongin complex IDA
IDA: 通过直接分析推断
7660122 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ELOB 蛋白结构

ubiquitin

ubiquitin: Ubiquitin family (11 - 64)

  • 0
  • 100
  • 118 a.a.
蛋白主名 其他名称

elongin-B

RNA polymerase II transcription factor SIII p18 subunit

ELOB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ELOB Q15370 MRPL53 Homo sapiens Q96EL3
Validated Y2H
32296183
Intra ELOB Q15370 ELOC Homo sapiens Q15369
Anti Tag CoIP
12149480
Intra ELOB Q15370 ELOC Homo sapiens Q15369
X-Ray Diffraction
12050673
Intra ELOB Q15370 ELOC Homo sapiens Q15369
Y2H Array
25416956
Intra ELOB Q15370 ELOC Homo sapiens Q15369
X-Ray Diffraction
10205047
Intra ELOB Q15370 ELOC Homo sapiens Q15369
X-Ray Diffraction
12004076
Intra ELOB Q15370 ELOC Homo sapiens Q15369
Y2H Prey Pooling
25416956
Intra ELOB Q15370 ELOC Homo sapiens Q15369
ITC
12004076
Intra ELOB Q15370 MED8 Homo sapiens Q96G25
Anti Tag CoIP
12149480
Intra ELOB Q15370 MED8 Homo sapiens Q96G25
Y2H
12149480
Cross ELOB Q15370 vif Human immunodeficiency virus P12504
Pull Down
22190034
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Von Hippel-Lindau Syndrome

Von Hippel-Lindau Disease

Vhl

Vhl Syndrome

VHLS

Von Hippel-Lindau Syndrome, Modifier Of

Hippel Lindau Syndrome

Angiomatosis Retinae

Cerebelloretinal Angiomatosis, Familial

Hippel-Lindau Disease

Familial Cerebelloretinal Angiomatosis

Lindau Disease

VHLD
Molluscum Contagiosum

Water Warts

Molluscum Verrucosum
Retinal Hemangioblastoma

Capillary Hemangioma Of Retina
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Erythrocytosis, Familial, 4

ECYT4

Familial Erythrocytosis 4

Erythrocytosis, Familial, Type 4
Familial Renal Papillary Carcinoma

Hereditary Papillary Renal Carcinoma

Papillary Renal Cancer Hereditary
Primary Polycythemia

Familial Erythrocytosis

Familiar Polycythemia

Benign Familial Polycythemia

Congenital Erythrocytosis

Familial Polycythemia

Hereditary Erythrocytosis

Primary Familial Polycythemia

Erythrocytosis, Familial

Polycythemia Vera

Primary Familial Polycythaemia

Primary Inherited Polycythaemia
Erythrocytosis, Familial, 2

Chuvash Polycythemia

ECYT2

Familial Erythrocytosis 2

Autosomal Recessive Benign Erythrocytosis

Polycythemia, Vhl-Dependent

Chuvash Erythromatosis

Chuvash Type Polycythemia

Chuvash Erythrocytosis

Von Hippel-Lindau-Dependent Polycythemia

Polycythemia Chuvash Type

Vhl-Dependent Polycythemia

Erythrocytosis, Familial, Type 2
Kidney Cancer

Renal Cancer

Renal Carcinoma

Kidney Neoplasm

Malignant Neoplasm Of Kidney Except Pelvis

Malignant Tumour Of Kidney

Kidney Neoplasms

Cancer, Kidney

Cancer, Renal

Malignant Neoplasm Of Kidney

Renal Cell Carcinoma
Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant
Hereditary Renal Cell Carcinoma
Cardiovascular Organ Benign Neoplasm
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04318 ELOB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ELOB RGD RGD:621200
Canis familiaris ELOB VGNC VGNC:40316
Mus musculus ELOB MGD MGI:1914923
Felis catus ELOB VGNC VGNC:80570
Others ELOB NCBI
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