2. Gene
  3. MED8 - mediator complex subunit 8 Gene

MED8 - mediator complex subunit 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：调解复合体亚基 8

种属: Homo sapiens

同用名: ARC32

基因 ID: 112950 | 基因类型: protein coding

关于 MED8

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:43,383,917-43,389,800 (from NCBI)

This gene has 5 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in thyroid (RPKM 12.7), placenta (RPKM 11.6) and 25 other tissues.

功能概要

该基因编码介体复合物的蛋白质成分，通过与 RNA 聚合酶 II 和基因特异性转录因子的相互作用帮助转录激活。编码的蛋白质也可能在泛素连接和蛋白质降解中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2013 年 1 月]

This gene encodes a protein component of the mediator complex, which aids in transcriptional activation through interaction with RNA polymerase II and gene-specific transcription factors. The encoded protein may also function in ubiquitin ligation and protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

MED8 基因产物(3)

mRNA Protein Name
NM_001001653.3 NP_001001653.1 mediator of RNA polymerase II transcription subunit 8 isoform 1
NM_052877.5 NP_443109.2 mediator of RNA polymerase II transcription subunit 8 isoform 3
NM_201542.5 NP_963836.2 mediator of RNA polymerase II transcription subunit 8 isoform 4
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12149480 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of core mediator complex IPI
IPI: 通过物理相互作用推断
24882805 GOA
part of mediator complex IDA
IDA: 通过直接分析推断
14638676 GOA
located in nucleus IDA
IDA: 通过直接分析推断
24882805 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MED8 蛋白结构

Med8

Med8: Mediator of RNA polymerase II transcription complex subunit 8 (1 - 268)

  • 0
  • 100
  • 200
  • 268 a.a.
蛋白主名 其他名称

mediator of RNA polymerase II transcription subunit 8

activator-recruited cofactor 32 kDa component

MED8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MED8 Q96G25 ELOC Homo sapiens Q15369
CoIP
12149480
Intra MED8 Q96G25 ELOC Homo sapiens Q15369
Anti Tag CoIP
12149480
Intra MED8 Q96G25 ELOB Homo sapiens Q15370
CoIP
12149480
Intra MED8 Q96G25 ELOB Homo sapiens Q15370
Y2H
12149480
Intra MED8 Q96G25 ELOB Homo sapiens Q15370
Anti Tag CoIP
12149480
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Phlebotomus Fever

Pappataci Fever

Sandfly Fever

Sandfly-Borne Phleboviral Disease

Sandfly-Borne Arboviral Fever

Sandfly-Borne Bunyavirus Fever

Three Day Fever

Chitral Fever

Italy Summer Grippe

Italy Summer Grippe Influenza
La Crosse Encephalitis

California Encephalitis

California Virus Encephalitis

Neuroinvasive California Encephalitis Virus Infection

Californian Encephalitis

Encephalitis, California

California Meningoencephalitis

California Encephalitis Virus Infection

California Encephalitis Virus Infection Neuroinvasive Disease

California Meningoencephalitis Virus Disease

California Serogroup Virus Neuroinvasive Disease

California Viral Encephalitis

Ce - [California Encephalitis]

Lac - [La Crosse Encephalitis]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08306 MED8 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MED8 VGNC VGNC:63443
Rattus norvegicus MED8 RGD RGD:1305552
Mus musculus MED8 MGD MGI:1915269
Macaca mulatta MED8 VGNC VGNC:74540
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z