2. Gene
  3. SOCS2 - suppressor of cytokine signaling 2 Gene

SOCS2 - suppressor of cytokine signaling 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞因子信号传导抑制因子 2

种属: Homo sapiens

同用名: CIS2; SSI2; Cish2; SSI-2; SOCS-2; STATI2

基因 ID: 8835 | 基因类型: protein coding

关于 SOCS2

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:93,569,969-93,626,236 (from NCBI)

This gene has 12 transcripts (splice variants), 209 orthologues and 7 paralogues. Broad expression in endometrium (RPKM 13.5), prostate (RPKM 10.5) and 22 other tissues.

功能概要

该基因编码细胞因子信号转导抑制因子 (SOCS) 家族的成员。 SOCS 家族成员是细胞因子可诱导的细胞因子受体负调节因子，通过 Janus 激酶/信号转导和转录通路 (JAK/STAT 通路) 的激活进行细胞因子受体信号传导。 SOCS 家族蛋白与信号复合物的主要分子相互作用以阻断进一步的信号转导，部分原因是蛋白酶体通过泛素化耗尽受体或信号转导蛋白。该基因的表达可由细胞因子子集诱导，包括促红细胞生成素、GM-CSF、IL10、干扰素 (IFN) -γ 和细胞因子受体，如生长激素受体。由该基因编码的蛋白质与胰岛素样生长因子 1 受体 (IGF1R) 的细胞质结构域相互作用，被认为参与了 IGF1R 介导的细胞信号传导的调节。该基因在 20 号和 22 号染色体上具有假基因。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 7 月]

This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by Cytokine Receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

SOCS2 基因产物(6)

mRNA Protein Name
NM_001270467.2 NP_001257396.1 suppressor of cytokine signaling 2
NM_001270468.2 NP_001257397.1 suppressor of cytokine signaling 2
NM_001270469.2 NP_001257398.1 suppressor of cytokine signaling 2
NM_001270470.1 NP_001257399.1 suppressor of cytokine signaling 2
NM_001270471.2 NP_001257400.1 suppressor of cytokine signaling 2
NM_003877.5 NP_003868.1 suppressor of cytokine signaling 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables insulin-like growth factor receptor binding IPI
IPI: 通过物理相互作用推断
9727029 GOA
enables phosphorylation-dependent protein binding IDA
IDA: 通过直接分析推断
11781573 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11781573 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: 通过直接分析推断
11781573 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hormone stimulus IDA
IDA: 通过直接分析推断
12552091 GOA
involved in growth hormone receptor signaling pathway IDA
IDA: 通过直接分析推断
12552091 GOA
involved in negative regulation of growth hormone receptor signaling pathway IDA
IDA: 通过直接分析推断
21980433 GOA
involved in negative regulation of signal transduction IDA
IDA: 通过直接分析推断
11781573 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
11781573 GOA
involved in response to estradiol IDA
IDA: 通过直接分析推断
12552091 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul5-RING ubiquitin ligase complex IDA
IDA: 通过直接分析推断
21980433 GOA
is active in cytoplasm IDA
IDA: 通过直接分析推断
9727029 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SOCS2 蛋白结构

SH2

SH2: SH2 domain (48 - 129)

SOCS_box

SOCS_box: SOCS box (161 - 195)

  • 0
  • 100
  • 198 a.a.
蛋白主名 其他名称

suppressor of cytokine signaling 2

CIS-2

SOCS2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SOCS2 O14508 CUL5 Homo sapiens Q93034
Lumier
29997244
Intra SOCS2 O14508 CUL5 Homo sapiens Q93034
Pull Down
30833792
Intra SOCS2 O14508 CUL5 Homo sapiens Q93034
Anti Tag CoIP
33961781
Intra SOCS2 O14508 CUL5 Homo sapiens Q93034
BRET
29997244
Intra SOCS2 O14508 CUL5 Homo sapiens Q93034
Anti Tag CoIP
28514442
Intra SOCS2 O14508 CUL5 Homo sapiens Q93034
Lumier
32814053
Intra SOCS2 O14508 KIT Homo sapiens P10721
FPS
24728074
Intra SOCS2 O14508 ELOC Homo sapiens Q15369
Anti Tag CoIP
19159283
Intra SOCS2 O14508 YES1 Homo sapiens P07947
Validated Y2H
32296183
Intra SOCS2 O14508 EPOR Homo sapiens P19235
MAPPIT
11781573
Intra SOCS2 O14508 STK16 Homo sapiens O75716
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Placental Insufficiency

Uteroplacental Vascular Insufficiency
Essential Thrombocythemia

Essential Thrombocytosis

Familial Thrombocytosis

Hemorrhagic Thrombocythemia

Hereditary Thrombocythemia

Primary Thrombocytosis

Idiopathic Thrombocythemia

Primary Thrombocythemia

Thrombocythemia, Essential

Essential Thrombocythaemia

Et

Familial Thrombocythemia

Thrombocythemia Essential
Polycythemia Vera

PV

Polycythemia Rubra Vera

Prv

Osler-Vaquez Disease

Chronic Erythremia

Polycythaemia Rubra Vera

Primary Polycythemia

Vaquez Disease

Polycythemia Vera, Somatic

Osler-Vaquez Syndrome

Proliferative Polycythaemia

Polycythemia Ruba Vera

Acquired Primary Erythrocytosis

Heilmeyer-Schoner Disease

Vaquez Osler Disease

Primary Polycythaemia
Glycine N-Methyltransferase Deficiency

GNMT DEFICIENCY

Hypermethioninemia Due To Glycine N-Methyltransferase Deficiency

Hypermethioninemia Due To Gnmt Deficiency

Hypermethioninemia

Hepatic Methionine Adenosyltransferase Deficiency
Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-156395 MN551 Inducer 98.05% 否
HY-RS13553 SOCS2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SOCS2 MGD MGI:1201787
Felis catus SOCS2 VGNC VGNC:97640
Canis familiaris SOCS2 VGNC VGNC:46649
Rattus norvegicus SOCS2 RGD RGD:69273
Bos taurus SOCS2 VGNC VGNC:35120
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