CAND1 - cullin associated and neddylation dissociated 1 Gene

中文名称：cullin 相关和 neddylation 解离 1

种属: Homo sapiens

同用名: TIP120; TIP120A

关于 CAND1

功能概要

该基因编码 Cullin-RING 泛素连接酶的重要调节因子，该连接酶参与 Ub 蛋白酶体系统降解的蛋白质泛素化。编码的蛋白质与未被修饰的 cullin-RING 盒蛋白复合物结合，并作为 cullin neddylation 和 Skp1、cullin 和 F 盒泛素连接酶复合物组装和活性的抑制剂。在哺乳动物细胞培养物中，这种蛋白质主要定位于细胞质。前脂肪细胞中该基因的敲低导致脂肪生成受阻。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 7 月]

This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub Proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin Ligase complex assembly and activity. In Mammalian Cell Culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]