CUL4A - cullin 4A Gene

中文名称：库林 4A

种属: Homo sapiens

基因 ID: 8451 | 基因类型: protein coding

关于 CUL4A

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,208,193-113,267,108 (from NCBI)

This gene has 12 transcripts (splice variants), 206 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 20.5), heart (RPKM 17.9) and 25 other tissues.

功能概要

CUL4A 是参与 DNA 损伤反应蛋白降解的多聚体复合物的泛素连接酶成分 (Liu 等人，2009 [PubMed 19481525]) 。[OMIM 提供，2009 年 10 月]

CUL4A is the ubiquitin Ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009]

CUL4A 基因产物(11)

mRNA	Protein	Name
NM_001008895.4	NP_001008895.1	cullin-4A isoform 1
NM_001278513.3	NP_001265442.1	cullin-4A isoform 2
NM_001278514.3	NP_001265443.1	cullin-4A isoform 3
NM_001354938.2	NP_001341867.1	cullin-4A isoform 2
NM_001354939.2	NP_001341868.1	cullin-4A isoform 2
NM_001354940.2	NP_001341869.1	cullin-4A isoform 2
NM_001354941.2	NP_001341870.1	cullin-4A isoform 4
NM_001354942.2	NP_001341871.1	cullin-4A isoform 4
NM_001354943.2	NP_001341872.1	cullin-4A isoform 5
NM_001354944.2	NP_001341873.1	cullin-4A isoform 6
NM_003589.4	NP_003580.1	cullin-4A isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	12504025	GOA
enables ubiquitin ligase complex scaffold activity	IDA IDA: 通过直接分析推断	34065512	GOA
enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	20870715	GOA
enables ubiquitin protein ligase binding	IDA IDA: 通过直接分析推断	11027288	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	EXP EXP: 通过实验结果推断	22118460	GOA
involved in T cell activation	IDA IDA: 通过直接分析推断	34065512	GOA
involved in cellular response to UV	EXP EXP: 通过实验结果推断	22118460	GOA
involved in positive regulation of protein catabolic process	IDA IDA: 通过直接分析推断	11027288	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	14739464	GOA
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	26431207	GOA
involved in protein ubiquitination	IMP IMP: 通过突变表型推断	28437394	GOA
involved in ribosome biogenesis	IMP IMP: 通过突变表型推断	26711351	GOA
involved in spermatogenesis	IDA IDA: 通过直接分析推断	34065512	GOA
involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	IDA IDA: 通过直接分析推断	34065512	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Cul4-RING E3 ubiquitin ligase complex	IDA IDA: 通过直接分析推断	16949367	GOA
part of Cul4A-RING E3 ubiquitin ligase complex	EXP EXP: 通过实验结果推断	22118460	GOA
part of Cul4A-RING E3 ubiquitin ligase complex	IDA IDA: 通过直接分析推断	12732143	GOA
is active in cytoplasm	IDA IDA: 通过直接分析推断	34065512	GOA
is active in nucleus	IDA IDA: 通过直接分析推断	10585395	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CUL4A 蛋白结构

Cullin

Cullin_Nedd8

0
200
400
600
759 a.a.

蛋白主名

其他名称

cullin-4A

CUL-4A

CUL4A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	CUL4A	Q13619	DDB2	Homo sapiens	Q92466	Anti Bait CoIP	17041588
Intra	CUL4A	Q13619	DDB2	Homo sapiens	Q92466	Anti Tag CoIP	30945288
Intra	CUL4A	Q13619	DDB2	Homo sapiens	Q92466	TAP	21145461
Intra	CUL4A	Q13619	UBXN7	Homo sapiens	O94888	Anti Tag CoIP	22466964
Intra	CUL4A	Q13619	DDB1	Homo sapiens	Q16531	Anti Tag CoIP	30945288
Intra	CUL4A	Q13619	DDB1	Homo sapiens	Q16531	TAP	21145461
Intra	CUL4A	Q13619	DDB1	Homo sapiens	Q16531	Anti Bait CoIP	17041588
Intra	CUL4A	Q13619	DDB1	Homo sapiens	Q16531	Pull Down	22157821
Intra	CUL4A	Q13619	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	CUL4A	Q13619	HSP90AB1	Homo sapiens	P08238	TAP	21145461
Intra	CUL4A	Q13619	VCP	Homo sapiens	P55072	Anti Tag CoIP	22466964
Intra	CUL4A	Q13619	CAND1	Homo sapiens	Q86VP6	CoIP	12609982
Intra	CUL4A	Q13619	CAND1	Homo sapiens	Q86VP6	Anti Bait CoIP	12504026
Intra	CUL4A	Q13619	CAND1	Homo sapiens	Q86VP6	TAP	21145461

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum V	Xp5
Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype	Xpe
Xp, Group E	Xeroderma Pigmentosum, Type 5
Xeroderma Pigmentosum Complementation Group E	XP-E
Xp Group E

Cockayne Syndrome

Cockayne'S Syndrome	Dwarfism-Retinal Atrophy-Deafness Syndrome
Neill-Dingwall Syndrome	Progeria-Like Syndrome
Progeroid Nanism	Cs

Xeroderma Pigmentosum Group E

Xeroderma Pigmentosum, Group E	Xeroderma Pigmentosum V
Xp Group E	Xp5
Xpe	Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum, Complementation Group C

Xeroderma Pigmentosum, Group C	XPC
Xpcc	Xeroderma Pigmentosum Iii
Xp3	Xeroderma Pigmentosum Group C
Xp Group C	Xp, Group C
Xeroderma Pigmentosum, Type 3	Xeroderma Pigmentosum Complementation Group C
XP-C

Childhood Medulloblastoma

Medulloblastoma, Childhood	Pediatric Medulloblastoma
Medulloblastoma Childhood

Cockayne Syndrome A

Cockayne Syndrome Type 1	Cockayne Syndrome, Type A
Cockayne Syndrome Type I	CSA
Cockayne Syndrome Classic Form	Cockayne Syndrome Classical
Cockayne Syndrome Type A	Ckn1

De Sanctis-Cacchione Syndrome

Xerodermic Idiocy	Xeroderma Pigmentosum With Neurologic Manifestation
DSC	Xerodermic Idiocy Of De Sanctis And Cacchione

Uv-Sensitive Syndrome

Uvss	Uv Sensitive Syndrome
Ultraviolet Sensitive Syndrome

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Three M Syndrome 1

3-M Syndrome	Yakut Short Stature Syndrome
3m Syndrome	Le Merrer Syndrome
Dolichospondylic Dysplasia	Gloomy Face Syndrome
Three M Syndrome	3M1
3m Syndrome 1	Miller-Mckusick-Malvaux Syndrome
3-Msbn	Three-M Slender-Boned Nanism
Miller-Mckusick-Malvaux-Syndrome	3-M Syndrome 1
3m Syndrome-1	3m Syndrome, Type 1
Dwarfism	Dwarfism Tall Vertebrae

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-148602	KH-4-43		99.99%	否
HY-161166	MM-02-57		/	否
HY-RS03362	CUL4A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	CUL4A	VGNC	VGNC:27832
Rattus norvegicus	CUL4A	RGD	RGD:1563853
Mus musculus	CUL4A	MGD	MGI:1914487
Macaca mulatta	CUL4A	VGNC	VGNC:71568
Felis catus	CUL4A	VGNC	VGNC:97394
Canis familiaris	CUL4A	VGNC	VGNC:39731
Others	CUL4A	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CUL4A - cullin 4A Gene

关于 CUL4A

功能概要

CUL4A 基因产物(11)

CUL4A 蛋白结构

CUL4A 蛋白互作信息

关联疾病

直系同源

热门区域

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CUL4A - cullin 4A Gene

关于 CUL4A

功能概要

CUL4A 基因产物(11)

CUL4A 蛋白结构

CUL4A 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z