COMMD1 - copper metabolism domain containing 1 Gene

中文名称：含铜代谢域 1

种属: Homo sapiens

同用名: MURR1; C2orf5

基因 ID: 150684 | 基因类型: protein coding

关于 COMMD1

Cytogenetic location: 2p15 Genomic coordinates (GRCh38): 2:61,888,391-62,136,058 (from NCBI)

This gene has 8 transcripts (splice variants) and 222 orthologues. Ubiquitous expression in heart (RPKM 5.7), testis (RPKM 5.6) and 25 other tissues.

功能概要

COMMD1 是铜稳态、钠摄取和 NF-kappa-B (参见 MIM 164011) 信号的调节剂 (de Bie 等人，2005 [PubMed 16267171]) 。[OMIM 提供，2009 年 9 月]

COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009]

COMMD1 基因产物(4)

mRNA	Protein	Name
NM_001321781.3	NP_001308710.1	COMM domain-containing protein 1 isoform 2
NM_001321782.3	NP_001308711.1	COMM domain-containing protein 1 isoform 2
NM_001371765.2	NP_001358694.1	COMM domain-containing protein 1 isoform 2
NM_152516.4	NP_689729.1	COMM domain-containing protein 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables copper ion binding	IDA IDA: 通过直接分析推断	17309234	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	15799966	GOA
enables phosphatidic acid binding	IDA IDA: 通过直接分析推断	18940794	GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: 通过直接分析推断	18940794	GOA
enables phosphatidylinositol-3,4-bisphosphate binding	IDA IDA: 通过直接分析推断	18940794	GOA
enables phosphatidylinositol-3,5-bisphosphate binding	IDA IDA: 通过直接分析推断	18940794	GOA
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: 通过直接分析推断	18940794	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12968035	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	15799966	GOA
enables sodium channel inhibitor activity	IDA IDA: 通过直接分析推断	14645214	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Golgi to plasma membrane transport	IMP IMP: 通过突变表型推断	25355947	GOA
involved in copper ion homeostasis	IDA IDA: 通过直接分析推断	14685266	GOA
acts upstream of or within negative regulation of NF-kappaB transcription factor activity	IDA IDA: 通过直接分析推断	16573520	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: 通过直接分析推断	15799966	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: 通过突变表型推断	17183367	GOA
involved in negative regulation of protein localization to cell surface	IDA IDA: 通过直接分析推断	21741370	GOA
involved in negative regulation of sodium ion transmembrane transport	IDA IDA: 通过直接分析推断	14645214	GOA
involved in negative regulation of sodium ion transmembrane transport	IMP IMP: 通过突变表型推断	20237237	GOA
involved in nucleotide-excision repair	IMP IMP: 通过突变表型推断	23144634	GOA
involved in plasma membrane to endosome transport	IDA IDA: 通过直接分析推断	21741370	GOA
involved in positive regulation of protein ubiquitination	IDA IDA: 通过直接分析推断	17183367	GOA
involved in regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	17183367	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Cul2-RING ubiquitin ligase complex	IDA IDA: 通过直接分析推断	17183367	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	14685266	GOA
located in early endosome	IDA IDA: 通过直接分析推断	25355947	GOA
located in nucleus	IDA IDA: 通过直接分析推断	15799966	GOA
located in recycling endosome	IDA IDA: 通过直接分析推断	21741370	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

COMMD1 蛋白结构

COMM_domain

0
100
190 a.a.

蛋白主名

其他名称

COMM domain-containing protein 1

copper metabolism (Murr1) domain containing 1

COMMD1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	COMMD1	Q8N668	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	37172566
种属内	COMMD1	Q8N668	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	33961781
种属内	COMMD1	Q8N668	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	28514442
种属内	COMMD1	Q8N668	CCDC93	Homo sapiens	Q567U6	Anti Bait CoIP	25355947
种属内	COMMD1	Q8N668	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	35271311
种属内	COMMD1	Q8N668	CCDC93	Homo sapiens	Q567U6	Pull Down	25355947
种属内	COMMD1	Q8N668	CCDC93	Homo sapiens	Q567U6	Confocal	25355947
种属内	COMMD1	Q8N668	ATP7B	Homo sapiens	P35670	Pull Down	12968035
种属内	COMMD1	Q8N668	ATP7B	Homo sapiens	P35670	Confocal	17919502
种属内	COMMD1	Q8N668	COMMD4	Homo sapiens	Q9H0A8	Anti Tag CoIP	37172566
种属内	COMMD1	Q8N668	COMMD4	Homo sapiens	Q9H0A8	Anti Tag CoIP	33961781
种属内	COMMD1	Q8N668	COMMD4	Homo sapiens	Q9H0A8	Anti Tag CoIP	28514442
种属内	COMMD1	Q8N668	COMMD4	Homo sapiens	Q9H0A8	TAP	23563313
种属内	COMMD1	Q8N668	COMMD4	Homo sapiens	Q9H0A8	Pull Down	15799966
种属内	COMMD1	Q8N668	COMMD4	Homo sapiens	Q9H0A8	TAP	15799966
种属内	COMMD1	Q8N668	COMMD4	Homo sapiens	Q9H0A8	Anti Tag CoIP	35271311
种属内	COMMD1	Q8N668	COMMD4	Homo sapiens	Q9H0A8	GMS	37172566
种属内	COMMD1	Q8N668	COMMD4	Homo sapiens	Q9H0A8	3D-EM	37172566
种属内	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Anti Tag CoIP	35271311
种属内	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Y2H Array	25416956
种属内	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Pull Down	15799966
种属内	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Y2H Array	32296183
种属内	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Validated Y2H	25416956
种属内	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Anti Tag CoIP	37172566
种属内	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	TAP	23563313
种属内	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	3D-EM	37172566
种属内	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Anti Tag CoIP	33961781
种属内	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Anti Bait CoIP	23563313
种属内	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	GMS	37172566
种属内	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Y2H Prey Pooling	25416956
种属内	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	TAP	15799966
种属内	COMMD1	Q8N668	COMMD6	Homo sapiens	Q7Z4G1	Y2H Prey Pooling	32296183
种属内	COMMD1	Q8N668	CCDC22	Homo sapiens	O60826	Anti Bait CoIP	23563313
种属内	COMMD1	Q8N668	COMMD2	Homo sapiens	Q86X83	Anti Tag CoIP	28514442
种属内	COMMD1	Q8N668	COMMD2	Homo sapiens	Q86X83	3D-EM	37172566
种属内	COMMD1	Q8N668	COMMD2	Homo sapiens	Q86X83	Anti Tag CoIP	35271311
种属内	COMMD1	Q8N668	COMMD2	Homo sapiens	Q86X83	Anti Tag CoIP	33961781
种属内	COMMD1	Q8N668	COMMD2	Homo sapiens	Q86X83	Anti Tag CoIP	37172566
种属内	COMMD1	Q8N668	COMMD5	Homo sapiens	Q9GZQ3	Anti Tag CoIP	33961781
种属内	COMMD1	Q8N668	COMMD5	Homo sapiens	Q9GZQ3	Anti Tag CoIP	28514442
种属内	COMMD1	Q8N668	COMMD5	Homo sapiens	Q9GZQ3	Anti Tag CoIP	35271311
种属内	COMMD1	Q8N668	COMMD5	Homo sapiens	Q9GZQ3	3D-EM	37172566
种属内	COMMD1	Q8N668	COMMD5	Homo sapiens	Q9GZQ3	Anti Tag CoIP	37172566
种属内	COMMD1	Q8N668	COMMD5	Homo sapiens	Q9GZQ3	Pull Down	15799966
种属内	COMMD1	Q8N668	COMMD7	Homo sapiens	Q86VX2	Anti Tag CoIP	33961781
种属内	COMMD1	Q8N668	COMMD7	Homo sapiens	Q86VX2	3D-EM	37172566
种属内	COMMD1	Q8N668	COMMD7	Homo sapiens	Q86VX2	Pull Down	15799966
种属内	COMMD1	Q8N668	COMMD7	Homo sapiens	Q86VX2	Anti Tag CoIP	35271311
种属内	COMMD1	Q8N668	COMMD10	Homo sapiens	Q9Y6G5	3D-EM	37172566
种属内	COMMD1	Q8N668	COMMD10	Homo sapiens	Q9Y6G5	Anti Tag CoIP	33961781
种属内	COMMD1	Q8N668	COMMD10	Homo sapiens	Q9Y6G5	Anti Tag CoIP	28514442
种属内	COMMD1	Q8N668	COMMD10	Homo sapiens	Q9Y6G5	Anti Tag CoIP	37172566
种属内	COMMD1	Q8N668	COMMD10	Homo sapiens	Q9Y6G5	Pull Down	15799966
种属内	COMMD1	Q8N668	COMMD10	Homo sapiens	Q9Y6G5	Anti Tag CoIP	35271311
种属内	COMMD1	Q8N668	TCEAL8	Homo sapiens	Q8IYN2	Y2H Prey Pooling	32296183
种属内	COMMD1	Q8N668	TCEAL8	Homo sapiens	Q8IYN2	Y2H Array	32296183
种属内	COMMD1	Q8N668	SCNN1D	Homo sapiens	P51172	Pull Down	14645214
种属内	COMMD1	Q8N668	ELOC	Homo sapiens	Q15369	Pull Down	23563313
种属内	COMMD1	Q8N668	ELOC	Homo sapiens	Q15369	Pull Down	17183367
种属内	COMMD1	Q8N668	REL	Homo sapiens	Q04864	Anti Bait CoIP	15799966
种属内	COMMD1	Q8N668	REL	Homo sapiens	Q04864	Pull Down	15799966
种属内	COMMD1	Q8N668	NFKBIA	Homo sapiens	P25963	Anti Tag CoIP	14685242
种属内	COMMD1	Q8N668	RELB	Homo sapiens	Q01201	Pull Down	15799966
种属内	COMMD1	Q8N668	CUL2	Homo sapiens	Q13617	Pull Down	23563313
种属内	COMMD1	Q8N668	CUL2	Homo sapiens	Q13617	Pull Down	17183367
种属内	COMMD1	Q8N668	COMMD3	Homo sapiens	Q9UBI1	3D-EM	37172566
种属内	COMMD1	Q8N668	COMMD3	Homo sapiens	Q9UBI1	Anti Tag CoIP	33961781
种属内	COMMD1	Q8N668	COMMD3	Homo sapiens	Q9UBI1	Anti Tag CoIP	28514442
种属内	COMMD1	Q8N668	COMMD3	Homo sapiens	Q9UBI1	TAP	23563313
种属内	COMMD1	Q8N668	COMMD3	Homo sapiens	Q9UBI1	TAP	15799966
种属内	COMMD1	Q8N668	COMMD3	Homo sapiens	Q9UBI1	Anti Tag CoIP	37172566
种属内	COMMD1	Q8N668	COMMD8	Homo sapiens	Q9NX08	Anti Tag CoIP	37172566
种属内	COMMD1	Q8N668	COMMD8	Homo sapiens	Q9NX08	Pull Down	15799966
种属内	COMMD1	Q8N668	COMMD8	Homo sapiens	Q9NX08	Anti Tag CoIP	28514442
种属内	COMMD1	Q8N668	COMMD8	Homo sapiens	Q9NX08	3D-EM	37172566
种属内	COMMD1	Q8N668	COMMD8	Homo sapiens	Q9NX08	Anti Tag CoIP	33961781
种属内	COMMD1	Q8N668	COMMD8	Homo sapiens	Q9NX08	GMS	37172566
种属内	COMMD1	Q8N668	COMMD8	Homo sapiens	Q9NX08	Anti Tag CoIP	35271311
种属内	COMMD1	Q8N668	RELA	Homo sapiens	Q04206	Anti Bait CoIP	15799966
种属内	COMMD1	Q8N668	RELA	Homo sapiens	Q04206	Pull Down	15799966
种属内	COMMD1	Q8N668	UPRT	Homo sapiens	Q96BW1	Validated Y2H	32296183
种属内	COMMD1	Q8N668	SOCS1	Homo sapiens	O15524	Pull Down	17183367

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Wilson Disease

Hepatolenticular Degeneration	WD
Wilson'S Disease	WND
Westphal-Strumpell Syndrome	Copper Storage Disease
Cerebral Pseudosclerosis	Westphal Pseudosclerosis
Hepatolenticular Degeneration Syndrome	Copper Retention
Hepatocerebral Degeneration	Kinnier-Wilson Disease
Neurohepatic Degeneration	Progressive Hepatolenticular Degeneration
Lenticular Degenerative Disease	Wilson'S Syndrome
Lenticular Syndrome

Nephrotic Syndrome, Type 20

NPHS20	Nephrotic Syndrome Type 20
Nephrotic Syndrome 20

Peroxisome Biogenesis Disorder 11a

PBD11A	Peroxisome Biogenesis Disorder Complementation Group 13
PBD-CG13	Cg13
Pbd-Cgh	Peroxisome Biogenesis Disorder Complementation Group H
Peroxisome Biogenesis Disorder, Type 11a	Peroxisome Biogenesis Disorder, Complementation Group 13

Retinitis Pigmentosa 28

RP28	Retinitis Pigmentosa, Type 28

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Menkes Disease

Copper Transport Disease	Menkes Syndrome
MNK	Kinky Hair Disease
Steely Hair Disease	Menkes Kinky-Hair Syndrome
Mk	Steely Hair Syndrome
Menkea Syndrome	Md
Menkes Kinky Hair Syndrome	Hypocupremia, Congenital
Kinky Hair Syndrome	X-Linked Copper Deficiency
Menkes Kinky Hair Disease

Metal Metabolism Disorder

Metal Metabolism, Inborn Errors

Inborn Metal Metabolism Disorder

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Aceruloplasminemia

Cerebellar Ataxia	Hypoceruloplasminemia
Hemosiderosis, Systemic, Due To Aceruloplasminemia	Familial Apoceruloplasmin Deficiency
Hereditary Ceruloplasmin Deficiency	Deficiency Of Ferroxidase
Hypoceruloplasminemia, Hereditary	Ceruloplasmin Deficiency
Systemic Hemosiderosis Due To Aceruloplasminemia	ACERULOP

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03009	COMMD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	COMMD1	RGD	RGD:1311771
Bos taurus	COMMD1	VGNC	VGNC:27581
Canis familiaris	COMMD1	VGNC	VGNC:39491
Felis catus	COMMD1	VGNC	VGNC:61074
Mus musculus	COMMD1	MGD	MGI:109474
Macaca mulatta	COMMD1	VGNC	VGNC:82130

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

COMMD1 - copper metabolism domain containing 1 Gene

关于 COMMD1

功能概要

COMMD1 基因产物(4)

COMMD1 蛋白结构

COMMD1 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

COMMD1 - copper metabolism domain containing 1 Gene

关于 COMMD1

功能概要

COMMD1 基因产物(4)

COMMD1 蛋白结构

COMMD1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z