2. Gene
  3. PBX4 - PBX homeobox 4 Gene

PBX4 - PBX homeobox 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：PBX 同源盒 4

种属: Homo sapiens

基因 ID: 80714 | 基因类型: protein coding

关于 PBX4

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:19,561,713-19,618,687 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues and 12 paralogues. Broad expression in thyroid (RPKM 3.9), testis (RPKM 2.5) and 18 other tissues.

功能概要

该基因编码前 B 细胞白血病转录因子家族的成员。这些蛋白质是同源框蛋白，在胚胎发育和细胞分化中作为 Hox 辅因子和通过 Hox 独立途径发挥关键作用。编码的蛋白质包含同源框 DNA 结合域，但蛋白质的具体功能尚未确定。已观察到该基因的可变剪接转录物变体。[RefSeq 提供，2011 年 5 月]

This gene encodes a member of the pre-B cell leukemia transcription factor family. These proteins are homeobox proteins that play critical roles in embryonic development and cellular differentiation both as Hox cofactors and through Hox-independent pathways. The encoded protein contains a homeobox DNA-binding domain, but specific functions of the protein have not been determined. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]

PBX4 基因产物(1)

mRNA Protein Name
NM_025245.3 NP_079521.1 pre-B-cell leukemia transcription factor 4
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PBX4 蛋白结构

PBC

PBC: PBC domain (15 - 209)

Homeobox

Homeobox: Homeobox domain (211 - 270)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
蛋白主名 其他名称

pre-B-cell leukemia transcription factor 4

homeobox protein PBX4

PBX4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PBX4 Q9BYU1 PIH1D2 Homo sapiens Q8WWB5
Y2H Array
32296183
种属内
PBX4 Q9BYU1 PIH1D2 Homo sapiens Q8WWB5
Y2H Prey Pooling
32296183
种属内
PBX4 Q9BYU1 ARHGEF3 Homo sapiens Q9NR81
Validated Y2H
32296183
种属内
PBX4 Q9BYU1 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Array
32814053
种属内
PBX4 Q9BYU1 GTF3C3 Homo sapiens Q9Y5Q9
Validated Y2H
32814053
种属内
PBX4 Q9BYU1 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Pooling
32814053
种属内
PBX4 Q9BYU1 TFIP11 Homo sapiens Q9UBB9
Y2H Array
31515488
种属内
PBX4 Q9BYU1 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
25416956
种属内
PBX4 Q9BYU1 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
25416956
种属内
PBX4 Q9BYU1 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
种属内
PBX4 Q9BYU1 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
种属内
PBX4 Q9BYU1 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
种属内
PBX4 Q9BYU1 NEK6 Homo sapiens Q9HC98-4
Validated Y2H
32296183
种属内
PBX4 Q9BYU1 CPNE7 Homo sapiens Q9UBL6-2
Validated Y2H
32296183
种属内
PBX4 Q9BYU1 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
种属内
PBX4 Q9BYU1 HOXD4 Homo sapiens P09016
Y2H Prey Pooling
32296183
种属内
PBX4 Q9BYU1 HOXD4 Homo sapiens P09016
Y2H Array
32296183
种属内
PBX4 Q9BYU1 PKNOX1 Homo sapiens P55347
Y2H Prey Pooling
32296183
种属内
PBX4 Q9BYU1 PKNOX1 Homo sapiens P55347
Y2H Array
32296183
种属内
PBX4 Q9BYU1 PKNOX1 Homo sapiens P55347
Anti Tag CoIP
33961781
种属内
PBX4 Q9BYU1 CHCHD2 Homo sapiens Q9Y6H1
Validated Y2H
32296183
种属内
PBX4 Q9BYU1 PKNOX2 Homo sapiens Q96KN3
Y2H Array
32296183
种属内
PBX4 Q9BYU1 PKNOX2 Homo sapiens Q96KN3
Anti Tag CoIP
33961781
种属内
PBX4 Q9BYU1 PKNOX2 Homo sapiens Q96KN3
Y2H Prey Pooling
32296183
种属内
PBX4 Q9BYU1 CCM2L Homo sapiens Q9NUG4
Validated Y2H
32296183
种属内
PBX4 Q9BYU1 ZNF330 Homo sapiens Q9Y3S2
Validated Y2H
32296183
种属内
PBX4 Q9BYU1 HOXB2 Homo sapiens P14652
Y2H Prey Pooling
32296183
种属内
PBX4 Q9BYU1 HOXB2 Homo sapiens P14652
Y2H Array
32296183
种属内
PBX4 Q9BYU1 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
种属内
PBX4 Q9BYU1 TRIM41 Homo sapiens Q8WV44
Y2H Prey Pooling
32296183
种属内
PBX4 Q9BYU1 PACSIN2 Homo sapiens Q9UNF0
Validated Y2H
32296183
种属内
PBX4 Q9BYU1 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
种属内
PBX4 Q9BYU1 IPO13 Homo sapiens O94829
Y2H Prey Pooling
25416956
种属内
PBX4 Q9BYU1 IPO13 Homo sapiens O94829
Y2H Prey Pooling
32296183
种属内
PBX4 Q9BYU1 IPO13 Homo sapiens O94829
Y2H Array
32296183
种属内
PBX4 Q9BYU1 SERTAD1 Homo sapiens Q9UHV2
Y2H Prey Pooling
32296183
种属内
PBX4 Q9BYU1 SERTAD1 Homo sapiens Q9UHV2
Validated Y2H
32296183
种属内
PBX4 Q9BYU1 SERTAD1 Homo sapiens Q9UHV2
Y2H Array
32296183
种属内
PBX4 Q9BYU1 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
种属内
PBX4 Q9BYU1 MEIS2 Homo sapiens O14770-4
Y2H Array
32296183
种属内
PBX4 Q9BYU1 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
种属内
PBX4 Q9BYU1 IFT20 Homo sapiens Q8IY31-3
Y2H Prey Pooling
32296183
种属内
PBX4 Q9BYU1 IFT20 Homo sapiens Q8IY31-3
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
Cantu Syndrome

Hypertrichotic Osteochondrodysplasia

Hypertrichotic Osteochondrodysplasia Cantu Type

Cantú Syndrome

Craniofaciocardioskeletal Syndrome

Hypertrichosis-Osteochondrodysplasia-Cardiomegaly Syndrome

Congenital Hypertrichosis-Acromegaloid Facial Features Spectrum

Congenital Hypertrichosis-Coarse Facial Features Spectrum

HTOCD

Osteochondrodysplasia, Hypertrichotic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10109 PBX4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PBX4 VGNC VGNC:44289
Felis catus PBX4 VGNC VGNC:64057
Bos taurus PBX4 VGNC VGNC:32610
Rattus norvegicus PBX4 RGD RGD:1305100
Mus musculus PBX4 MGD MGI:1931321
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