HOXD4 - homeobox D4 Gene

中文名称：同源框 D4

种属: Homo sapiens

同用名: HOX4; HOX4B; HHO.C13; HOX-5.1; Hox-4.2

关于 HOXD4

功能概要

该基因属于同源盒基因家族。同源框基因编码一个高度保守的转录因子家族，在所有多细胞生物的形态发生中起着重要作用。哺乳动物拥有 4 个相似的同源盒基因簇 HOXA、HOXB、HOXC 和 HOXD，分别位于不同的染色体上，由 9～11 个串联排列的基因组成。该基因是位于 2q31-2q37 染色体区域的几个同源框 HOXD 基因之一。移除整个 HOXD 基因簇或该簇 5' 端的缺失与严重的肢体和生殖器异常有关。由该基因编码的蛋白质可能在决定肢芽发育过程中的位置值方面发挥作用。已经描述了选择性剪接变体，但尚未确定其全长性质。[RefSeq 提供，2008 年 7 月]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]