HOXB2 - homeobox B2 Gene

中文名称：同源框 B2

种属: Homo sapiens

同用名: K8; HOX2; HOX2H; Hox-2.8

基因 ID: 3212 | 基因类型: protein coding

关于 HOXB2

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,542,655-48,545,109 (from NCBI)

This gene has 3 transcripts (splice variants), 194 orthologues and 42 paralogues. Broad expression in kidney (RPKM 11.3), fat (RPKM 6.5) and 19 other tissues.

功能概要

该基因是 Antp 同源框家族的成员，编码具有同源框 DNA 结合域的核蛋白。它包含在位于 17 号染色体上的同源框 B 基因簇中。编码的蛋白质作为参与发育的序列特异性转录因子发挥作用。该基因表达增加与胰腺癌有关。[RefSeq 提供，2008 年 7 月]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic Cancer. [provided by RefSeq, Jul 2008]

HOXB2 基因产物(1)

mRNA	Protein	Name
NM_002145.4	NP_002136.1	homeobox protein Hox-B2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	15289435	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12080061	GOA
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	23332764	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	15289435	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HOXB2 蛋白结构

Homeobox

0
100
200
300
356 a.a.

蛋白主名

其他名称

homeobox protein Hox-B2

K8 home protein

HOXB2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HOXB2	P14652	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
种属内	HOXB2	P14652	NDOR1	Homo sapiens	Q9UHB4	Validated Y2H	32296183
种属内	HOXB2	P14652	PBX4	Homo sapiens	Q9BYU1	Validated Y2H	32296183
种属内	HOXB2	P14652	ZNF410	Homo sapiens	Q86VK4-3	Validated Y2H	32296183
种属内	HOXB2	P14652	RUNX1T1	Homo sapiens	Q06455-2	Validated Y2H	32296183
种属内	HOXB2	P14652	UBASH3B	Homo sapiens	Q8TF42	Validated Y2H	32296183
种属内	HOXB2	P14652	TNKS2	Homo sapiens	Q9H2K2	Anti Tag CoIP	35016035
种属内	HOXB2	P14652	DTX2	Homo sapiens	Q86UW9	Validated Y2H	32296183
种属内	HOXB2	P14652	MORN3	Homo sapiens	Q6PF18	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06306	HOXB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	HOXB2	VGNC	VGNC:54955
Bos taurus	HOXB2	VGNC	VGNC:29918
Felis catus	HOXB2	VGNC	VGNC:99077
Mus musculus	HOXB2	MGD	MGI:96183
Rattus norvegicus	HOXB2	RGD	RGD:2319509

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