1. Gene
  2. NDOR1 - NADPH dependent diflavin oxidoreductase 1 Gene

NDOR1 - NADPH dependent diflavin oxidoreductase 1 Gene

中文名称:NADPH 依赖性二黄素氧化还原酶 1

种属: Homo sapiens

同用名: NR1; CIAE1; bA350O14.9

基因 ID: 27158 | 基因类型: protein coding

关于 NDOR1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,205,700-137,219,361 (from NCBI)

This gene has 6 transcripts (splice variants), 190 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 6.1), bone marrow (RPKM 5.1) and 25 other tissues.

功能概要

该基因编码的 NADPH 依赖性二黄素还原酶包含黄素单核苷酸 (FMN) 和黄素腺嘌呤二核苷酸 (FAD) 结合域。编码的蛋白质催化电子从 NADPH 通过 FAD 和 FMN 辅助因子转移到潜在的氧化还原伙伴。可变剪接导致多个转录本变体。[RefSeq 提供,2012 年 3 月]

This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

NDOR1 基因产物(4)

mRNA Protein Name
NM_001144026.3 NP_001137498.1 NADPH-dependent diflavin oxidoreductase 1 isoform a
NM_001144027.3 NP_001137499.1 NADPH-dependent diflavin oxidoreductase 1 isoform d
NM_001144028.3 NP_001137500.1 NADPH-dependent diflavin oxidoreductase 1 isoform c
NM_014434.4 NP_055249.1 NADPH-dependent diflavin oxidoreductase 1 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables FAD binding IDA
IDA: 通过直接分析推断
10625700 GOA
enables FMN binding IDA
IDA: 通过直接分析推断
10625700 GOA
enables NADP binding IDA
IDA: 通过直接分析推断
15900210 GOA
enables NADPH binding IDA
IDA: 通过直接分析推断
10625700 GOA
enables NADPH-hemoprotein reductase activity IDA
IDA: 通过直接分析推断
10625700 GOA
enables electron transfer activity IDA
IDA: 通过直接分析推断
12631275 GOA
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor IDA
IDA: 通过直接分析推断
12871938 GOA
enables oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor IDA
IDA: 通过直接分析推断
23596212 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16140270 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in electron transport chain IDA
IDA: 通过直接分析推断
10625700 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10625700 GOA
located in cytosol IDA
IDA: 通过直接分析推断
16140270 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NDOR1 蛋白结构

Flavodoxin_1

Flavodoxin_1: Flavodoxin (8 - 145)

FAD_binding_1

FAD_binding_1: FAD binding domain (204 - 421)

NAD_binding_1

NAD_binding_1: Oxidoreductase NAD-binding domain (455 - 560)

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  • 597 a.a.
蛋白主名 其他名称

NADPH-dependent diflavin oxidoreductase 1

NADPH-dependent FMN and FAD-containing oxidoreductase

NDOR1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NDOR1 Q9UHB4 ZNF774 Homo sapiens Q6NX45 32296183
种属内
NDOR1 Q9UHB4 ZNF774 Homo sapiens Q6NX45 32296183
种属内
NDOR1 Q9UHB4 GAS8 Homo sapiens O95995 32296183
种属内
NDOR1 Q9UHB4 GAS8 Homo sapiens O95995 32296183
种属内
NDOR1 Q9UHB4 CENATAC Homo sapiens Q86UT8 32296183
种属内
NDOR1 Q9UHB4 CENATAC Homo sapiens Q86UT8 32296183
种属内
NDOR1 Q9UHB4 TEPSIN Homo sapiens Q96N21 32296183
种属内
NDOR1 Q9UHB4 TEPSIN Homo sapiens Q96N21 32296183
种属内
NDOR1 Q9UHB4 MTUS2 Homo sapiens Q5JR59-3 32296183
种属内
NDOR1 Q9UHB4 MTUS2 Homo sapiens Q5JR59-3 32296183
种属内
NDOR1 Q9UHB4 TLE5 Homo sapiens Q08117-2 32296183
种属内
NDOR1 Q9UHB4 TLE5 Homo sapiens Q08117-2 32296183
种属内
NDOR1 Q9UHB4 LMO3 Homo sapiens Q8TAP4-4 32296183
种属内
NDOR1 Q9UHB4 LMO3 Homo sapiens Q8TAP4-4 32296183
种属内
NDOR1 Q9UHB4 LMO2 Homo sapiens P25791-3 32296183
种属内
NDOR1 Q9UHB4 LMO2 Homo sapiens P25791-3 32296183
种属内
NDOR1 Q9UHB4 ZBTB42 Homo sapiens B2RXF5 32296183
种属内
NDOR1 Q9UHB4 ZBTB42 Homo sapiens B2RXF5 32296183
种属内
NDOR1 Q9UHB4 TCF4 Homo sapiens P15884-3 32296183
种属内
NDOR1 Q9UHB4 ZC2HC1C Homo sapiens Q53FD0-2 32296183
种属内
NDOR1 Q9UHB4 ZC2HC1C Homo sapiens Q53FD0-2 32296183
种属内
NDOR1 Q9UHB4 MEOX1 Homo sapiens P50221 32296183
种属内
NDOR1 Q9UHB4 MEOX1 Homo sapiens P50221 32296183
种属内
NDOR1 Q9UHB4 PSMB6 Homo sapiens P28072 32296183
种属内
NDOR1 Q9UHB4 PSMB6 Homo sapiens P28072 32296183
种属内
NDOR1 Q9UHB4 NLK Homo sapiens Q9UBE8 32296183
种属内
NDOR1 Q9UHB4 NLK Homo sapiens Q9UBE8 32296183
种属内
NDOR1 Q9UHB4 GLRX3 Homo sapiens O76003 33961781
种属内
NDOR1 Q9UHB4 GLRX3 Homo sapiens O76003 27519415
种属内
NDOR1 Q9UHB4 ZNF620 Homo sapiens Q6ZNG0 32296183
种属内
NDOR1 Q9UHB4 ZNF620 Homo sapiens Q6ZNG0 32296183
种属内
NDOR1 Q9UHB4 HOXB2 Homo sapiens P14652 32296183
种属内
NDOR1 Q9UHB4 HOXB2 Homo sapiens P14652 32296183
种属内
NDOR1 Q9UHB4 TCF4 Homo sapiens P15884 25416956
种属内
NDOR1 Q9UHB4 GPS2 Homo sapiens Q13227 32296183
种属内
NDOR1 Q9UHB4 GPS2 Homo sapiens Q13227 32296183
种属内
NDOR1 Q9UHB4 KIAA0408 Homo sapiens Q6ZU52 32296183
种属内
NDOR1 Q9UHB4 KIAA0408 Homo sapiens Q6ZU52 32296183
种属内
NDOR1 Q9UHB4 LNX1 Homo sapiens Q8TBB1 32296183
种属内
NDOR1 Q9UHB4 LNX1 Homo sapiens Q8TBB1 32296183
种属内
NDOR1 Q9UHB4 TCHP Homo sapiens Q9BT92 32296183
种属内
NDOR1 Q9UHB4 TCHP Homo sapiens Q9BT92 32296183
种属内
NDOR1 Q9UHB4 TCHP Homo sapiens Q9BT92 25416956
种属内
NDOR1 Q9UHB4 UBQLN1 Homo sapiens Q9UMX0 32296183
种属内
NDOR1 Q9UHB4 UBQLN1 Homo sapiens Q9UMX0 32296183
种属内
NDOR1 Q9UHB4 UBQLN1 Homo sapiens Q9UMX0 32296183
种属内
NDOR1 Q9UHB4 MTUS2 Homo sapiens Q5JR59 25416956
种属内
NDOR1 Q9UHB4 CIAPIN1 Homo sapiens Q6FI81 25416956
种属内
NDOR1 Q9UHB4 CIAPIN1 Homo sapiens Q6FI81 31515488
种属内
NDOR1 Q9UHB4 CIAPIN1 Homo sapiens Q6FI81 25416956
种属内
NDOR1 Q9UHB4 CIAPIN1 Homo sapiens Q6FI81 27519415
种属内
NDOR1 Q9UHB4 CIAPIN1 Homo sapiens Q6FI81 33961781
种属内
NDOR1 Q9UHB4 NAB2 Homo sapiens Q15742 32296183
种属内
NDOR1 Q9UHB4 NAB2 Homo sapiens Q15742 32296183
种属内
NDOR1 Q9UHB4 UBQLN2 Homo sapiens Q9UHD9 32296183
种属内
NDOR1 Q9UHB4 UBQLN2 Homo sapiens Q9UHD9 32296183
种属内
NDOR1 Q9UHB4 UBQLN2 Homo sapiens Q9UHD9 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Dyschromatosis Universalis Hereditaria

Duh

Atrophic Rhinitis

Rhinitis, Atrophic

Ozena

Rhinitis Sicca

Dry Rhinitis

Ozaena

Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta NDOR1 VGNC VGNC:75050
Bos taurus NDOR1 VGNC VGNC:31938
Rattus norvegicus NDOR1 RGD RGD:1308479
Mus musculus NDOR1 MGD MGI:1926047
Felis catus NDOR1 VGNC VGNC:63753
Canis familiaris NDOR1 VGNC VGNC:43677