NLK - nemo like kinase Gene

中文名称：尼莫样激酶

种属: Homo sapiens

基因 ID: 51701 | 基因类型: protein coding

关于 NLK

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,042,677-28,206,074 (from NCBI)

This gene has 6 transcripts (splice variants), 220 orthologues and 19 paralogues. Ubiquitous expression in brain (RPKM 18.0), adrenal (RPKM 18.0) and 25 other tissues.

功能概要

启用泛素蛋白连接酶结合活性。参与蛋白质稳定和转化生长因子β受体信号通路。预计位于胞质溶胶和核质中。预计在细胞质和细胞核中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Enables ubiquitin protein Ligase binding activity. Involved in protein stabilization and transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NLK 基因产物(1)

mRNA	Protein	Name
NM_016231.5	NP_057315.3	serine/threonine-protein kinase NLK

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	16714285	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16713569	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	26588989	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	16714285	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to osmotic stress	IDA IDA: 通过直接分析推断	26588989	GOA
involved in negative regulation of TORC1 signaling	IDA IDA: 通过直接分析推断	26588989	GOA
involved in protein stabilization	IDA IDA: 通过直接分析推断	25512613	GOA
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: 通过突变表型推断	15004007	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NLK 蛋白结构

Pkinase

0
100
200
300
400
527 a.a.

蛋白主名

其他名称

serine/threonine-protein kinase NLK

NLK 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	NLK	Q9UBE8	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Array	25416956
Intra	NLK	Q9UBE8	NDOR1	Homo sapiens	Q9UHB4	Validated Y2H	32296183
Intra	NLK	Q9UBE8	QRICH1	Homo sapiens	Q2TAL8	Y2H Prey Pooling	25416956
Intra	NLK	Q9UBE8	QRICH1	Homo sapiens	Q2TAL8	Y2H Array	25416956
Intra	NLK	Q9UBE8	SMAD4	Homo sapiens	Q13485	Anti Tag CoIP	21988832
Intra	NLK	Q9UBE8	SMAD4	Homo sapiens	Q13485	Confocal	21988832
Intra	NLK	Q9UBE8	SMAD4	Homo sapiens	Q13485	Y2H Array	21988832
Intra	NLK	Q9UBE8	SMAD4	Homo sapiens	Q13485	TAP	23602568
Intra	NLK	Q9UBE8	KRTAP5-9	Homo sapiens	P26371	Y2H Array	25416956
Intra	NLK	Q9UBE8	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
Intra	NLK	Q9UBE8	GRN	Homo sapiens	P28799	Y2H Array	31515488
Intra	NLK	Q9UBE8	GRN	Homo sapiens	P28799	Y2H Array	25416956
Intra	NLK	Q9UBE8	GRN	Homo sapiens	P28799	Y2H Prey Pooling	25416956
Intra	NLK	Q9UBE8	TFDP1	Homo sapiens	Q14186	Anti Bait CoIP	22773187
Intra	NLK	Q9UBE8	DAPK3	Homo sapiens	O43293	Anti Bait CoIP	21454679
Intra	NLK	Q9UBE8	ATXN1	Homo sapiens	P54253	Y2H	16713569
Intra	NLK	Q9UBE8	RCHY1	Homo sapiens	Q96PM5	Confocal	21988832
Intra	NLK	Q9UBE8	RCHY1	Homo sapiens	Q96PM5	Y2H Array	21988832

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 NLK 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76517	NLK/Nemo Like Kinase Protein, Human (sf9, His-GST)	Q9UBE8 (V121-E527)	≥95%

关联疾病

疾病名称

别名

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Leber Congenital Amaurosis 1

LCA1	Amaurosis Congenita Of Leber I
Lca	Retinal Blindness, Congenital
Crb	Leber Congenital Amaurosis Type I
Leber Congenital Amaurosis, Type 1	Amaurosis Congenita Of Leber, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-148063	DB0614		98.80%	否
HY-148061	DB1113		99.28%	否
HY-RS09344	NLK Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	NLK	RGD	RGD:1561602
Mus musculus	NLK	MGD	MGI:1201387
Bos taurus	NLK	VGNC	VGNC:32111
Macaca mulatta	NLK	VGNC	VGNC:75277
Felis catus	NLK	VGNC	VGNC:63824
Canis familiaris	NLK	VGNC	VGNC:43841
Others	NLK	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NLK - nemo like kinase Gene

关于 NLK

功能概要

NLK 基因产物(1)

NLK 蛋白结构

NLK 蛋白互作信息

重组 NLK 蛋白

关联疾病

直系同源

热门区域

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NLK - nemo like kinase Gene

关于 NLK

功能概要

NLK 基因产物(1)

NLK 蛋白结构

NLK 蛋白互作信息

重组 NLK 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z