TFDP1 - transcription factor Dp-1 Gene

中文名称：转录因子 DP-1

种属: Homo sapiens

同用名: DP1; DILC; Dp-1; DRTF1

基因 ID: 7027 | 基因类型: protein coding

关于 TFDP1

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,584,688-113,641,473 (from NCBI)

This gene has 8 transcripts (splice variants), 239 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 54.1), lymph node (RPKM 31.4) and 24 other tissues.

功能概要

该基因编码转录因子家族的一个成员，这些转录因子与 E2F 蛋白异二聚化以增强其 DNA 结合活性并促进 E2F 靶基因的转录。编码的蛋白质作为该复合物的一部分起作用，以控制参与从 G1 期到 S 期的细胞周期进展的众多基因的转录活性。可变剪接导致多个转录本变体。该基因的假基因存在于染色体 1、15 和 X 上。[RefSeq 提供，2009 年 1 月]

This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]

TFDP1 基因产物(1)

mRNA	Protein	Name
NM_007111.5	NP_009042.1	transcription factor Dp-1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
contributes to DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	7739537	GOA
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	16360038	GOA
contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	7739537	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables protein domain specific binding	IPI IPI: 通过物理相互作用推断	16360038	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	17062573	GOA
involved in positive regulation of G1/S transition of mitotic cell cycle	IDA IDA: 通过直接分析推断	17062573	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	7739537	GOA
involved in regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	1531329	GOA
involved in transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	27825926	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of RNA polymerase II transcription regulator complex	IDA IDA: 通过直接分析推断	7739537	GOA
part of RNA polymerase II transcription regulator complex	IPI IPI: 通过物理相互作用推断	16360038	GOA
part of Rb-E2F complex	IPI IPI: 通过物理相互作用推断	16360038	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	17062573	GOA
located in nucleus	IDA IDA: 通过直接分析推断	1531329	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TFDP1 蛋白结构

E2F_TDP

0
100
200
300
410 a.a.

蛋白主名

其他名称

transcription factor Dp-1

DRTF1-polypeptide 1

TFDP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	TFDP1	Q14186	NLK	Homo sapiens	Q9UBE8	Anti Bait CoIP	22773187
Intra	TFDP1	Q14186	E2F1	Homo sapiens	Q01094	TAP	24981860
Intra	TFDP1	Q14186	E2F1	Homo sapiens	Q01094	TAP	27705803
Intra	TFDP1	Q14186	E2F1	Homo sapiens	Q01094	Pull Down	16360038
Intra	TFDP1	Q14186	E2F4	Homo sapiens	Q16254	TAP	24981860
Intra	TFDP1	Q14186	E2F4	Homo sapiens	Q16254	TAP	27705803
Intra	TFDP1	Q14186	E2F4	Homo sapiens	Q16254	Validated Y2H	32296183
Intra	TFDP1	Q14186	E2F4	Homo sapiens	Q16254	Y2H Array	32296183
Intra	TFDP1	Q14186	E2F4	Homo sapiens	Q16254	Y2H Prey Pooling	32296183
Intra	TFDP1	Q14186	E2F2	Homo sapiens	Q14209	TAP	24981860
Intra	TFDP1	Q14186	E2F2	Homo sapiens	Q14209	TAP	27705803
Intra	TFDP1	Q14186	DVL1	Homo sapiens	O14640	Anti Tag CoIP	22773187
Intra	TFDP1	Q14186	E2F6	Homo sapiens	O75461	Y2H Prey Pooling	32296183
Intra	TFDP1	Q14186	E2F6	Homo sapiens	O75461	TAP	24981860
Intra	TFDP1	Q14186	E2F6	Homo sapiens	O75461	TAP	27705803
Intra	TFDP1	Q14186	E2F6	Homo sapiens	O75461	Validated Y2H	25416956
Intra	TFDP1	Q14186	E2F6	Homo sapiens	O75461	Y2H Array	25416956
Intra	TFDP1	Q14186	E2F6	Homo sapiens	O75461	Y2H Array	32296183
Intra	TFDP1	Q14186	E2F6	Homo sapiens	O75461	Y2H Prey Pooling	25416956
Intra	TFDP1	Q14186	MAX	Homo sapiens	P61244	TAP	24981860
Intra	TFDP1	Q14186	MAX	Homo sapiens	P61244	TAP	27705803
Intra	TFDP1	Q14186	MAX	Homo sapiens	P61244	Pull Down	25609649

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14417	TFDP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	TFDP1	RGD	RGD:1560344
Macaca mulatta	TFDP1	VGNC	VGNC:106302
Mus musculus	TFDP1	MGD	MGI:101934
Felis catus	TFDP1	VGNC	VGNC:102343
Bos taurus	TFDP1	VGNC	VGNC:107256

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TFDP1 - transcription factor Dp-1 Gene

关于 TFDP1

功能概要

TFDP1 基因产物(1)

TFDP1 蛋白结构

TFDP1 蛋白互作信息

关联疾病

直系同源

热门区域

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TFDP1 - transcription factor Dp-1 Gene

关于 TFDP1

功能概要

TFDP1 基因产物(1)

TFDP1 蛋白结构

TFDP1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z