E2F4 - E2F transcription factor 4 Gene

中文名称：E2F 转录因子 4

种属: Homo sapiens

同用名: E2F-4

基因 ID: 1874 | 基因类型: protein coding

关于 E2F4

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,192,155-67,198,918 (from NCBI)

This gene has 13 transcripts (splice variants), 253 orthologues and 7 paralogues. Ubiquitous expression in bone marrow (RPKM 45.6), placenta (RPKM 31.6) and 25 other tissues.

功能概要

该基因编码的蛋白质是 E2F 转录因子家族的成员。 E2F 家族在控制细胞周期和肿瘤抑制蛋白的作用中起着至关重要的作用，也是小 DNA 肿瘤病毒转化蛋白的靶标。 E2F 蛋白包含几个在大多数家族成员中发现的进化保守结构域。这些结构域包括 DNA 结合结构域、决定与分化调节转录因子蛋白 (DP) 相互作用的二聚化结构域、富含酸性氨基酸的反式激活结构域，以及嵌入反式激活结构域内的肿瘤抑制蛋白关联结构域。该蛋白与所有三种肿瘤抑制蛋白 pRB、p107 和 p130 结合，但对后两种蛋白具有更高的亲和力。它在增殖相关基因的抑制中起重要作用，其基因突变和表达增加可能与人类癌症有关。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic Amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human Cancer. [provided by RefSeq, Jul 2008]

E2F4 基因产物(1)

mRNA	Protein	Name
NM_001950.4	NP_001941.2	transcription factor E2F4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IMP IMP: 通过突变表型推断	11418595	GOA
enables DNA-binding transcription activator activity	IDA IDA: 通过直接分析推断	17062573	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	11418595	GOA
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	11418595	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	10488129	GOA
enables promoter-specific chromatin binding	IDA IDA: 通过直接分析推断	25100735	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11418595	GOA
enables protein domain specific binding	IPI IPI: 通过物理相互作用推断	16360038	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	11418595	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IDA IDA: 通过直接分析推断	21454377	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	17062573	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

E2F4 蛋白结构

E2F_TDP

0
100
200
300
413 a.a.

蛋白主名

其他名称

transcription factor E2F4

E2F transcription factor 4, p107/p130-binding

E2F4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	E2F4	Q16254	LIN9	Homo sapiens	Q5TKA1	Anti Bait CoIP	17159899
种属内	E2F4	Q16254	KAT5	Homo sapiens	Q92993	Validated Y2H	32296183
种属内	E2F4	Q16254	RB1	Homo sapiens	P06400	ITC	16360038
种属内	E2F4	Q16254	TFDP1	Homo sapiens	Q14186	ITC	16360038
种属间	E2F4	Q16254	E7	Human papillomavirus	P03129	Affinity Chrom	16061792
种属内	E2F4	Q16254	RBL2	Homo sapiens	Q08999	Anti Bait CoIP	22002537
种属内	E2F4	Q16254	RBL2	Homo sapiens	Q08999	Anti Bait CoIP	20133863

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Epilepsy, Idiopathic Generalized 3

EIG3	Idiopathic Generalized Epilepsy 3
Epilepsy, Idiopathic Generalized, Susceptibility To, 3	Epilepsy, Idiopathic Generalized Locus On Chromosome 9
Epilepsy, Idiopathic Generalized, Susceptibility To, Locus On Chromosome 9	Epilepsy, Idiopathic Generalized, Susceptibility To 3

Retinal Cancer

Malignant Neoplasm Of Retina	Retinal Neoplasms
Malignant Retinal Neoplasm	Malignant Tumor Of Retina
Neoplasm Of Retina	Retinal Tumor
Retinal Neoplasm	Cancer Of The Retina
Malignant Retinal Tumour	Malignant Tumour Of Retina
Primary Malignant Neoplasm Of Retina

Alstrom Syndrome

ALMS	Alström Syndrome
Alss	Alstrom-Hallgren Syndrome
Alstroem Syndrome

Familial Retinoblastoma

Hereditary Retinoblastoma

Retinoblastoma

Ocular Cancer

Eye Neoplasm	Eye Carcinoma
Eye Cancer	Eye Neoplasms
Malignant Eye Neoplasm	Neoplasm Of Eye
Neoplasm Of Eye Proper	Ocular Tumor
Carcinoma Of Eye	Ocular Carcinoma
Malignant Tumor Of Eye

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Retinal Disease

Retinal Diseases	Retinal Disorder
Retinal Disorders

Soft Palate Cancer

Malignant Tumor Of Soft Palate	Malignant Tumor Of The Soft Palate
Palate Cancer Soft Palate

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-16667	HLM006474	Inhibitor	99.57%	否
HY-RS04113	E2F4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	E2F4	MGD	MGI:103012
Rattus norvegicus	E2F4	RGD	RGD:2322129
Macaca mulatta	E2F4	VGNC	VGNC:72025
Felis catus	E2F4	VGNC	VGNC:61696
Bos taurus	E2F4	VGNC	VGNC:28288
Canis familiaris	E2F4	VGNC	VGNC:40166

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

E2F4 - E2F transcription factor 4 Gene

关于 E2F4

功能概要

E2F4 基因产物(1)

E2F4 蛋白结构

E2F4 蛋白互作信息

关联疾病

直系同源

热门区域

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E2F4 - E2F transcription factor 4 Gene

关于 E2F4

功能概要

E2F4 基因产物(1)

E2F4 蛋白结构

E2F4 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z