2. Gene
  3. RBL2 - RB transcriptional corepressor like 2 Gene

RBL2 - RB transcriptional corepressor like 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RB 转录辅抑制因子 2

种属: Homo sapiens

同用名: Rb2; P130; BRUWAG

基因 ID: 5934 | 基因类型: protein coding

关于 RBL2

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:53,434,471-53,491,648 (from NCBI)

This gene has 9 transcripts (splice variants), 211 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 41.9), testis (RPKM 38.9) and 25 other tissues.

功能概要

启用启动子特异性染色质结合活性。参与脂质激酶活性的调节。在基因表达的负调控上游或负调控中起作用。位于染色体；胞质溶胶；和核腔。 [由基因组资源联盟提供，2022 年 4 月]

Enables promoter-specific chromatin binding activity. Involved in regulation of lipid kinase activity. Acts upstream of or within negative regulation of gene expression. Located in chromosome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

RBL2 基因产物(5)

mRNA Protein Name
NM_001323608.2 NP_001310537.1 retinoblastoma-like protein 2 isoform 1
NM_001323609.2 NP_001310538.1 retinoblastoma-like protein 2 isoform 2
NM_001323610.2 NP_001310539.1 retinoblastoma-like protein 2 isoform 3
NM_001323611.1 NP_001310540.1 retinoblastoma-like protein 2 isoform 4
NM_005611.4 NP_005602.3 retinoblastoma-like protein 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables promoter-specific chromatin binding IDA
IDA: 通过直接分析推断
25100735 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
1331501 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within negative regulation of gene expression IMP
IMP: 通过突变表型推断
25100735 GOA
involved in regulation of lipid kinase activity IDA
IDA: 通过直接分析推断
16286473 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RBL2 蛋白结构

DUF3452

DUF3452: Domain of unknown function (DUF3452) (101 - 239)

RB_A

RB_A: Retinoblastoma-associated protein A domain (417 - 609)

RB_B

RB_B: Retinoblastoma-associated protein B domain (834 - 1018)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1139 a.a.
蛋白主名 其他名称

retinoblastoma-like protein 2

130 kDa retinoblastoma-associated protein

RBL2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RBL2 Q08999 RBBP8 Homo sapiens Q99708-2
Y2H Prey Pooling
32296183
Intra RBL2 Q08999 RBBP8 Homo sapiens Q99708-2
Validated Y2H
32296183
Intra RBL2 Q08999 RBBP8 Homo sapiens Q99708-2
Y2H Array
32296183
Intra RBL2 Q08999 RBBP8 Homo sapiens I6L8A6
Y2H
27107012
Intra RBL2 Q08999 RBBP8 Homo sapiens I6L8A6
BFG-2H
27107012
Cross RBL2 Q08999 Pax3 Mus musculus P24610
Anti Bait CoIP
9464541
Cross RBL2 Q08999 Pax3 Mus musculus P24610
Y2H
9464541
Cross RBL2 Q08999 Vsx2 Mus musculus Q61412
Y2H
9464541
Cross RBL2 Q08999 Vsx2 Mus musculus Q61412
Pull Down
9464541
Intra RBL2 Q08999 LIN54 Homo sapiens Q6MZP7
Anti Tag CoIP
17531812
Intra RBL2 Q08999 LIN54 Homo sapiens Q6MZP7
Anti Bait CoIP
17531812
Cross RBL2 Q08999 Sirt1 Mus musculus Q923E4
Anti Tag CoIP
17620057
Intra RBL2 Q08999 CDK4 Homo sapiens P11802
Protein Kinase Assay
22094256
Intra RBL2 Q08999 E2F4 Homo sapiens Q16254
Anti Bait CoIP
17531812
Intra RBL2 Q08999 E2F4 Homo sapiens Q16254
Anti Tag CoIP
17531812
Intra RBL2 Q08999 E2F4 Homo sapiens Q16254
Anti Bait CoIP
22002537
Intra RBL2 Q08999 PPP2CA Homo sapiens P67775
Phosphatase Assay
15467457
Intra RBL2 Q08999 DGKZ Homo sapiens Q13574-2
Pull Down
16286473
Cross RBL2 Q08999 e1a_ade05 Human adenovirus C P03255
Pull Down
1331501
Cross RBL2 Q08999 e1a_ade05 Human adenovirus C P03255
Affinity Techniques
1331501
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Brunet-Wagner Neurodevelopmental Syndrome

BRUWAG
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms
Papilloma

Papillomatosis
Spastic Paraplegia 27, Autosomal Recessive

SPG27

Hereditary Spastic Paraplegia 27

Autosomal Recessive Spastic Paraplegia Type 27

Autosomal Recessive Spastic Paraplegia 27

Spastic Paraplegia-27, Autosomal Recessive
Bilateral Retinoblastoma
Unilateral Retinoblastoma
Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma
Retinal Cancer

Malignant Neoplasm Of Retina

Retinal Neoplasms

Malignant Retinal Neoplasm

Malignant Tumor Of Retina

Neoplasm Of Retina

Retinal Tumor

Retinal Neoplasm

Cancer Of The Retina

Malignant Retinal Tumour

Malignant Tumour Of Retina

Primary Malignant Neoplasm Of Retina
Familial Retinoblastoma

Hereditary Retinoblastoma

Retinoblastoma
Eye Disease

Eye Diseases

Abnormality Of The Eye

Toxoplasma Oculopathy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12504 Pyr6 Inhibitor 98.47% 否
HY-N2252 Licarin A Inhibitor 98.48% 否
HY-139247 pNPS-DHA / 否
HY-N8593 Undecane Inhibitor ≥98.0% 否
HY-N8593S Undecane-d24 / 否
HY-P1640 (Trp63,Trp64)​-​C3a(63-77) Agonist / 否
HY-RS11730 RBL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-N12116 Maceneolignan A Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RBL2 RGD RGD:3541
Canis familiaris RBL2 VGNC VGNC:45403
Macaca mulatta RBL2 VGNC VGNC:99582
Bos taurus RBL2 VGNC VGNC:33782
Felis catus RBL2 VGNC VGNC:69261
Mus musculus RBL2 MGD MGI:105085
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