Sirt1 - sirtuin 1 Gene

中文名称：沉默信息调节因子 2 相关酶类 1

种属: Mus musculus

同用名: Sir2; Sir2a; SIR2L1; Sir2alpha

关于 Sirt1

功能概要

该基因编码 Sirtuin 蛋白家族的一个成员，其特征在于它们的脱乙酰酶活性和拟议的长寿作用。编码的蛋白质通过组蛋白、转录因子和转录共激活因子的 NAD+ 依赖性去乙酰化作用，调节多种细胞和组织类型中的基因表达。该基因的大脑特异性过度表达已被证明会导致中位寿命延长。该基因的纯合基因敲除小鼠的生存能力随品系背景而变化。未表现出胚胎致死性的品系纯合基因敲除小鼠是不育的并且寿命缩短。可变剪接导致多个转录本变体。 [RefSeq 提供，2015 年 9 月]

This gene encodes a member of the Sirtuin family of proteins, characterized by their deacetylase activity and proposed role in longevity. The encoded protein regulates gene expression in a wide range of cell and tissue types through its NAD+-dependent deacetylation of histones, transcription factors and transcriptional coactivators. Brain-specific overexpression of this gene has been shown to result in increased median lifespan. Viability of homozygous knockout mice for this gene varies with strain background. Homozygous knockout mice of strains that do not exhibit embryonic lethality are sterile and have a reduced lifespan. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]