2. Gene
  3. Smad7 - SMAD family member 7 Gene

Smad7 - SMAD family member 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Madh7

基因 ID: 17131 | 基因类型: protein coding

关于 Smad7

功能概要

Enables collagen binding activity. Involved in several processes, including circulatory system development; negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; and negative regulation of protein phosphorylation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; negative regulation of BMP signaling pathway; and transforming growth factor beta receptor signaling pathway. Located in nucleus. Part of protein-containing complex. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and inner ear. Human ortholog(s) of this gene implicated in colorectal Cancer and pancreatic adenocarcinoma. Orthologous to human SMAD7 (Smad Family member 7). [provided by Alliance of Genome Resources, Apr 2022]

Smad7 基因产物(1)

mRNA Protein Name
NM_001042660.1 NP_001036125.1 mothers against decapentaplegic homolog 7
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables collagen binding IPI
IPI: 通过物理相互作用推断
14559231 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16601693 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in artery morphogenesis IMP
IMP: 通过突变表型推断
18952608 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: 通过表达模式推断
20439489 MGI
involved in cellular response to transforming growth factor beta stimulus IMP
IMP: 通过突变表型推断
18593713 MGI
acts upstream of or within negative regulation of BMP signaling pathway IDA
IDA: 通过直接分析推断
19850029 MGI
involved in negative regulation of SMAD protein signal transduction IMP
IMP: 通过突变表型推断
18952608 MGI
involved in negative regulation of T cell cytokine production IMP
IMP: 通过突变表型推断
25642768 MGI
involved in negative regulation of T-helper 17 cell differentiation IMP
IMP: 通过突变表型推断
25642768 MGI
involved in negative regulation of T-helper 17 type immune response IMP
IMP: 通过突变表型推断
25642768 MGI
involved in negative regulation of chondrocyte proliferation IDA
IDA: 通过直接分析推断
29503843 MGI
involved in negative regulation of ossification IDA
IDA: 通过直接分析推断
29503843 MGI
involved in negative regulation of peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
18593713 MGI
involved in negative regulation of peptidyl-threonine phosphorylation IMP
IMP: 通过突变表型推断
18593713 MGI
involved in positive regulation of cell-cell adhesion IMP
IMP: 通过突变表型推断
18593713 MGI
involved in positive regulation of chondrocyte hypertrophy IDA
IDA: 通过直接分析推断
29503843 MGI
involved in regulation of cardiac muscle contraction IMP
IMP: 通过突变表型推断
18952608 MGI
involved in regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
18952608 MGI
involved in regulation of ventricular cardiac muscle cell membrane depolarization IMP
IMP: 通过突变表型推断
18952608 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
11557747 MGI
involved in ureteric bud development IEP
IEP: 通过表达模式推断
14656760 MGI
involved in ventricular cardiac muscle tissue morphogenesis IMP
IMP: 通过突变表型推断
18952608 MGI
involved in ventricular septum morphogenesis IMP
IMP: 通过突变表型推断
18952608 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
16601693 MGI
part of protein-containing complex IDA
IDA: 通过直接分析推断
16601693 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

mothers against decapentaplegic homolog 7

MAD homolog 7

MAD homolog 8

SMAD 7

madh8

mothers against DPP homolog 7

mothers against DPP homolog 8

mothers against decapentaplegic homolog 8

Smad7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Smad7 O35253 Sirt1 Mus musculus Q923E4
Anti Tag CoIP
17098745
种属内
Smad7 O35253 Sirt1 Mus musculus Q923E4
Anti Bait CoIP
17098745
种属内
Smad7 O35253 Axin1 Mus musculus O35625
Anti Tag CoIP
16601693
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-145721 Mongersen Inhibitor / Phase 3
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0439 Asiaticoside 99.84% 否
HY-145721A Mongersen sodium 95.25% 否
HY-RS13398 SMAD7 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-N13208 Stevia Powder / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Smad7 NCBI NCBI:4092
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