2. Cell Cycle/DNA Damage Epigenetics Autophagy
  3. Sirtuin Autophagy
  4. SRT 1720 dihydrochloride

SRT 1720 dihydrochloride 

目录号: HY-15145A 纯度: 99.13%
COA 产品使用指南

摩尔计算器

SRT 1720 dihydrochloride 是选择性的和具有口服活性的 SIRT1 激活剂，EC50 为 0.10 μM，对 SIRT2 和 SIRT3 的作用较弱。

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SRT 1720 dihydrochloride Chemical Structure

SRT 1720 dihydrochloride Chemical Structure

CAS No. : 2468639-77-0

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥1490
In-stock
5 mg ￥1252
In-stock
10 mg ￥1870
In-stock
25 mg ￥3600
In-stock
50 mg ￥5300
In-stock
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of SRT 1720 dihydrochloride:

SRT 1720 dihydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 40 篇科研文献

WB
IF

    SRT 1720 dihydrochloride purchased from MCE. Usage Cited in: Exp Eye Res. 2023 Apr 2;109464.  [Abstract]

    SRT1720 (1 μM; 1 h) effectively decreases the levels of cell death and ROS accumulation in the UVA (Using ultraviolet A)-irradiated B4G12 cells.

    SRT 1720 dihydrochloride purchased from MCE. Usage Cited in: Exp Eye Res. 2023 Apr 2;109464.  [Abstract]

    SRT1720 (1 μM; 1 h) reverses UVA (Using ultraviolet A)-inhibited expression of PGC-1α, NRF2 and TFAM in B4G12 cells.

    SRT 1720 dihydrochloride purchased from MCE. Usage Cited in: Hypertension. 2016 Nov;68(5):1191-1199.  [Abstract]

    SRT1720 rescues the downregulation of SIRT1 activity and protein expression in the aortas of KL+/– mice. A, Representative Western blot bands of Acetyl-P53 and total P53 and the quantification of SIRT1 activity. Data are expressed as the ratio of acetyl-p53/total P53. B, Representative Western blot bands and quantitative analysis of SIRT1 protein expression in aortas. Protein expression is normalized to β-actin, and the relative expression calculated as the fold change relative

    SRT 1720 dihydrochloride purchased from MCE. Usage Cited in: Toxicol Lett. 2016 Dec 15;264:1-11.  [Abstract]

    The HNF1α, FXR, Mrp2 and Bsep protein levels are decreased after EE administration and significantly increased by SRT1720 in a dose dependent manner, which is in accordance with the mRNA levels.

    查看 Sirtuin 亚型特异性产品:

    查看所有亚型
    Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    SRT 1720 dihydrochloride is a selective and orally active activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3[1].

    IC50 & Target

    SIRT1

    0.10 μM (EC50)

    体外研究
    (In Vitro)

    即使在没有 SIRT1 的情况下，SRT 1720 dihydrochloride 也能有效地降低细胞中 p53 的乙酰化，这归因于组蛋白乙酰转移酶 p300[2]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    SRT 1720 dihydrochloride 相关抗体:
    体内研究
    (In Vivo)

    SRT 1720 (10, 30, 100 mg/kg, p.o.) dihydrochloride 处理显著降低 Lepob/ob 小鼠的空腹血糖至接近正常水平[1]。
    SRT 1720 dihydrochloride 能够保护小鼠免受饮食诱导的肥胖的负面影响，并通过 SIRT1 的下游靶点，如 PGC1α 和 FOXO1，与脂肪酸和氧化代谢的代谢适应有关[2]。
    SRT 1720 (50-100 mg/kg, p.o.) dihydrochloride 在肺气肿发展过程中减弱弹性酶诱导的气道扩大和肺功能损害，并降低野生小鼠的动脉氧饱和度[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    542.48

    Formula

    C25H25Cl2N7OS
    CAS 号
    性状

    固体

    颜色

    Brown to orange

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 85 mg/mL (156.69 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    H2O 中的溶解度 : 12.5 mg/mL (23.04 mM; 超声助溶)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.8434 mL 9.2169 mL 18.4339 mL
    5 mM 0.3687 mL 1.8434 mL 3.6868 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料
    参考文献
    Animal Administration
    [1]

    Mice: Nine week old C57BL/6 male mice are fed a high fat diet (60% calories from fat) until their mean body weight reach approximately 40 g. The mice are then divided into test groups (6-10 per group). SRT1460 (100 mg/kg), SRT 1720 (100 mg/kg), SRT501 (500 mg/kg) and BRL49653 (5 mg/kg) are administered once daily via oral gavage. The vehicle used is 2% HPMC + 0.2% DOSS. Individual mouse body weights are measured twice weekly. At 2, 4, 6, 8 and 10 weeks of dosing a fed blood glucose measure is taken and after 5 weeks of treatment an IPGTT is conducted on all mice from each of the groups. After 10 weeks of treatment, an ITT is conducted. Statistical analysis is completed using the JMP program. Data are analyzed by a one way ANOVA with comparison to control using a Dunnett’s Test. A p value < 0.05 indicates a significant difference between groups.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    SRT 1720 dihydrochloride 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 1.8434 mL 9.2169 mL 18.4339 mL 46.0846 mL
    5 mM 0.3687 mL 1.8434 mL 3.6868 mL 9.2169 mL
    10 mM 0.1843 mL 0.9217 mL 1.8434 mL 4.6085 mL
    15 mM 0.1229 mL 0.6145 mL 1.2289 mL 3.0723 mL
    20 mM 0.0922 mL 0.4608 mL 0.9217 mL 2.3042 mL
    DMSO 25 mM 0.0737 mL 0.3687 mL 0.7374 mL 1.8434 mL
    30 mM 0.0614 mL 0.3072 mL 0.6145 mL 1.5362 mL
    40 mM 0.0461 mL 0.2304 mL 0.4608 mL 1.1521 mL
    50 mM 0.0369 mL 0.1843 mL 0.3687 mL 0.9217 mL
    60 mM 0.0307 mL 0.1536 mL 0.3072 mL 0.7681 mL
    80 mM 0.0230 mL 0.1152 mL 0.2304 mL 0.5761 mL
    100 mM 0.0184 mL 0.0922 mL 0.1843 mL 0.4608 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SRT 17202468639-77-0SRT1720SRT-1720SirtuinAutophagyp53PGC1αFOXO1Inhibitorinhibitorinhibit

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