2. 一站式药筛
  3. 化合物库
  4. 生物活性化合物库系列
  5. 信号通路化合物库系列
  6. 细胞周期/DNA 损伤化合物库
细胞周期/DNA 损伤化合物库 - Cell Cycle/DNA Damage Compound Library

Cat. No.: HY-L004

DNA 容易受到多种形式的损伤，为了应对 DNA 损伤，细胞已经进化出一系列的修复机制。不断生长和增殖的细胞受到到 DNA 损伤的几率会更高。细胞周期检查点代表 DNA 修复的整体组成部分，通过协调细胞周期及其他生化途径，以应对损伤，恢复 DNA 结构。通过延迟细胞周期的进展，检查点在 DNA 复制的关键阶段 (基因组复制时) 和有丝分裂 (基因组分离时) 之前提供了更多的修复时间。检查点功能的缺失或衰减可以通过降低 DNA 修复的效率而增加自发性和诱导性基因突变和染色体畸变。

MCE 收录 2,114 个细胞周期调控及 DNA 损伤及修复相关的化合物，可以用于细胞周期调控、DNA 损伤及修复相关的研究。

我们将在明确您的产品用途后，向符合资质的客户通过定制合成服务的方式提供 MCE 细胞周期/DNA 损伤化合物库，我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中，2,053 个产品以 10 mM 浓度提供，53 个产品以 2 mM 浓度提供，8 个产品以 3 mg/mL 浓度提供。

溶液包装中，我们对于溶液状态稳定且溶解度不低于 10 mM 的产品，提供 10 mM 溶液；对于溶液状态稳定且溶解度介于 2~10 mM 的产品，我们提供 2 mM 溶液；对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品，我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

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MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 2,114 Cell Cycle/DNA Damage related compounds for high throughput screening (HTS) and high content screening (HCS).

•   Targets such as CDK, ROCK, Aurora Kinase, ATM/ATR, DNA-PK, DNA/RNA Synthesis, etc.

•   A useful tool to study the mechanism of cell cycle regulators that are critical to normal development and the development of cancer, cardiovascular, inflammatory, and neurodegenerative diseases.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some compounds have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   NMR and HPLC validated to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 2,114 Cell Cycle/DNA Damage related compounds supplied as pre-dissolved Solutions or Solid
Solution: 2,053 compounds supplied in 10 mM solution, 53 compounds supplied in 2 mM solution, 8 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

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  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式（固体或溶液）
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联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称：
    Cell Cycle/DNA Damage Compound Library
    目录号：
    HY-L004
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