RBL1 - RB transcriptional corepressor like 1 Gene

中文名称：RB 转录辅抑制因子 1

种属: Homo sapiens

同用名: PRB1; p107; CP107

基因 ID: 5933 | 基因类型: protein coding

关于 RBL1

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:36,996,349-37,095,997 (from NCBI)

This gene has 4 transcripts (splice variants), 194 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 3.5), bone marrow (RPKM 2.8) and 25 other tissues.

功能概要

该基因编码的蛋白质序列相似，可能与视网膜母细胞瘤 1 (RB1) 基因的产物具有相同的功能。 RB1 基因产物是一种肿瘤抑制蛋白，似乎参与细胞周期调节，因为它在 S 到 M 相转变时被磷酸化，在细胞周期的 G1 期去磷酸化。 RB1 蛋白和该基因的产物均可与腺病毒 E1A 蛋白和 SV40 大 T 抗原形成复合物，SV40 大 T 抗原仅与每种蛋白的非磷酸化形式结合。此外，这两种蛋白质都可以抑制其启动子中含有 E2F 结合位点的细胞周期基因的转录。由于与 RB1 蛋白的序列和生化相似性，人们认为该基因编码的蛋白也可能是一种肿瘤抑制因子。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RBL1 基因产物(4)

mRNA	Protein	Name
NM_001323281.2	NP_001310210.1	retinoblastoma-like protein 1 isoform c
NM_001323282.2	NP_001310211.1	retinoblastoma-like protein 1 isoform c
NM_002895.5	NP_002886.2	retinoblastoma-like protein 1 isoform a
NM_183404.4	NP_899662.1	retinoblastoma-like protein 1 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables promoter-specific chromatin binding	IDA IDA: 通过直接分析推断	25100735	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	1331501	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of cellular senescence	IMP IMP: 通过突变表型推断	28595801	GOA
acts upstream of or within negative regulation of gene expression	IMP IMP: 通过突变表型推断	25100735	GOA
involved in regulation of lipid kinase activity	IDA IDA: 通过直接分析推断	16286473	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleoplasm	IDA IDA: 通过直接分析推断	8245034	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RBL1 蛋白结构

DUF3452

RB_A

RB_B

Rb_C

0
200
400
600
800
1000
1068 a.a.

蛋白主名

其他名称

retinoblastoma-like protein 1

107 kDa retinoblastoma-associated protein

RBL1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	RBL1	P28749	DYRK1A	Homo sapiens	Q13627	BiFC	23602568
Intra	RBL1	P28749	FOXO3	Homo sapiens	O43524	Pull Down	25609649
Intra	RBL1	P28749	CDK4	Homo sapiens	P11802	Protein Kinase Assay	22094256
Intra	RBL1	P28749	PPP2CA	Homo sapiens	P67775	CoIP	15467457
Intra	RBL1	P28749	PPP2CA	Homo sapiens	P67775	Phosphatase Assay	15467457
Intra	RBL1	P28749	DGKZ	Homo sapiens	Q13574-2	Pull Down	16286473
Intra	RBL1	P28749	BEGAIN	Homo sapiens	Q9BUH8	Y2H Pooling	16189514
Cross	RBL1	P28749	E7	Human papillomavirus	P03129	Affinity Chrom	16061792
Cross	RBL1	P28749	E7	Human papillomavirus	P03129	SLC	22898364
Cross	RBL1	P28749	e1a_ade05	Human adenovirus C	P03255	Competition Binding	1331501

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Bilateral Retinoblastoma

Retinal Cancer

Malignant Neoplasm Of Retina	Retinal Neoplasms
Malignant Retinal Neoplasm	Malignant Tumor Of Retina
Neoplasm Of Retina	Retinal Tumor
Retinal Neoplasm	Cancer Of The Retina
Malignant Retinal Tumour	Malignant Tumour Of Retina
Primary Malignant Neoplasm Of Retina

Cecal Benign Neoplasm

Cecal Neoplasms	Cecum Neoplasm
Neoplasm Of Caecum	Cecal Neoplasm
Cecum Carcinoma	Malignant Neoplasm Of Cecum

Cecum Adenoma

Caecum Adenoma

Papilloma

Papillomatosis

Familial Retinoblastoma

Hereditary Retinoblastoma

Retinoblastoma

Unilateral Retinoblastoma

Ocular Cancer

Eye Neoplasm	Eye Carcinoma
Eye Cancer	Eye Neoplasms
Malignant Eye Neoplasm	Neoplasm Of Eye
Neoplasm Of Eye Proper	Ocular Tumor
Carcinoma Of Eye	Ocular Carcinoma
Malignant Tumor Of Eye

Intraocular Retinoblastoma

Pediatric Intraocular Retinoblastoma

Focal Epithelial Hyperplasia

Heck'S Disease	Heck Disease
Multifocal Epithelial Hyperplasia

Retinal Disease

Retinal Diseases	Retinal Disorder
Retinal Disorders

Osteogenic Sarcoma

Osteosarcoma	OSRC
Osteosarcoma, Somatic	Neoplasms, Bone Tissue
Bone Tissue Neoplasm	Osteoid Sarcoma
Skeletal Sarcoma	Osteosarcoma Of Bone
Bone Sarcoma

Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis	Epidermodysplasia Verruciformis, Susceptibility To, 1
Lutz-Lewandowsky Epidermodysplasia Verruciformis	EV1
Lewandowsky-Lutz Syndrome	Ev

Sensory System Disease

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-105024	FPL 62064	Inhibitor	99.25%	否
HY-N12231	Carbazomycin B	Inhibitor	/	否
HY-RS11729	RBL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	RBL1	VGNC	VGNC:69260
Bos taurus	RBL1	VGNC	VGNC:33781
Rattus norvegicus	RBL1	RGD	RGD:1595511
Mus musculus	RBL1	MGD	MGI:103300
Macaca mulatta	RBL1	VGNC	VGNC:76679
Canis familiaris	RBL1	VGNC	VGNC:45402

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