PPP2CA - protein phosphatase 2 catalytic subunit alpha Gene

中文名称：蛋白磷酸酶 2 催化亚基 α

种属: Homo sapiens

同用名: RP-C; PP2Ac; PP2CA; NEDLBA; PP2Calpha

基因 ID: 5515 | 基因类型: protein coding

关于 PPP2CA

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,194,332-134,226,073 (from NCBI)

This gene has 12 transcripts (splice variants), 287 orthologues, 12 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 63.8), bone marrow (RPKM 57.1) and 25 other tissues.

功能概要

该基因编码磷酸酶 2A 催化亚基。蛋白磷酸酶 2A 是四种主要的 Ser/Thr 磷酸酶之一，与细胞生长和分裂的负调控有关。它由一个共同的异聚核心酶组成，该核心酶由一个催化亚基和一个恒定的调节亚基组成，与多种调节亚基相关联。该基因编码催化亚基的α亚型。[RefSeq 提供，2008 年 7 月]

This gene encodes the Phosphatase 2A catalytic subunit. Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core Enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]

PPP2CA 基因产物(4)

mRNA	Protein	Name
NM_001355019.2	NP_001341948.1	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 2
NM_002715.4	NP_002706.1	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 1
NM_001355019.2	NP_001341948.1	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 2
NM_002715.4	NP_002706.1	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	1328865	GOA
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	9847399	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: 通过直接分析推断	25438055	GOA
enables protein tyrosine phosphatase activity	IDA IDA: 通过直接分析推断	15525651	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of epithelial to mesenchymal transition	IMP IMP: 通过突变表型推断	20080667	GOA
involved in negative regulation of hippo signaling	IDA IDA: 通过直接分析推断	33633399	GOA
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: 通过突变表型推断	21806946	GOA
involved in peptidyl-threonine dephosphorylation	IDA IDA: 通过直接分析推断	30611118	GOA
involved in peptidyl-threonine dephosphorylation	IMP IMP: 通过突变表型推断	15525651	GOA
involved in positive regulation of protein serine/threonine kinase activity	IMP IMP: 通过突变表型推断	20080667	GOA
involved in protein dephosphorylation	IMP IMP: 通过突变表型推断	33108758	GOA
involved in regulation of G1/S transition of mitotic cell cycle	IDA IDA: 通过直接分析推断	25438055	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of FAR/SIN/STRIPAK complex	IDA IDA: 通过直接分析推断	29063833	GOA
located in membrane raft	IDA IDA: 通过直接分析推断	16258073	GOA
part of protein phosphatase type 2A complex	IDA IDA: 通过直接分析推断	17055435	GOA
part of protein serine/threonine phosphatase complex	IDA IDA: 通过直接分析推断	29063833	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPP2CA 蛋白结构

Metallophos

0
100
200
309 a.a.

蛋白主名

其他名称

serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

PP2A-alpha

关联疾病

疾病名称

别名

Neurodevelopmental Disorder And Language Delay With Or Without Structural Brain Abnormalities

NEDLBA

Alzheimer Disease 15

AD15	Alzheimer'S Disease 15
Alzheimer Disease Without Neurofibrillary Tangles	Alzheimer'S Disease 15, Late Onset
Alzheimer'S Disease Without Neurofibrillary Tangles

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11007	PPP2CA Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	PPP2CA	VGNC	VGNC:33251
Mus musculus	PPP2CA	MGD	MGI:1321159
Felis catus	PPP2CA	VGNC	VGNC:102292
Rattus norvegicus	PPP2CA	RGD	RGD:3380
Others	PPP2CA	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PPP2CA - protein phosphatase 2 catalytic subunit alpha Gene

关于 PPP2CA

功能概要

PPP2CA 基因产物(4)

PPP2CA 蛋白结构

关联疾病

直系同源

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PPP2CA - protein phosphatase 2 catalytic subunit alpha Gene

关于 PPP2CA

功能概要

PPP2CA 基因产物(4)

PPP2CA 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z