PPP2CA - protein phosphatase 2 catalytic subunit alpha Gene

中文名称：蛋白磷酸酶 2 催化亚基 α

种属: Homo sapiens

同用名: RP-C; PP2Ac; PP2CA; NEDLBA; PP2Calpha

基因 ID: 5515 | 基因类型: protein coding

关于 PPP2CA

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,194,332-134,226,073 (from NCBI)

This gene has 12 transcripts (splice variants), 287 orthologues, 12 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 63.8), bone marrow (RPKM 57.1) and 25 other tissues.

功能概要

该基因编码磷酸酶 2A 催化亚基。蛋白磷酸酶 2A 是四种主要的 Ser/Thr 磷酸酶之一，与细胞生长和分裂的负调控有关。它由一个共同的异聚核心酶组成，该核心酶由一个催化亚基和一个恒定的调节亚基组成，与多种调节亚基相关联。该基因编码催化亚基的α亚型。[RefSeq 提供，2008 年 7 月]

This gene encodes the Phosphatase 2A catalytic subunit. Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core Enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]

PPP2CA 基因产物(4)

mRNA	Protein	Name
NM_001355019.2	NP_001341948.1	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 2
NM_002715.4	NP_002706.1	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 1
NM_001355019.2	NP_001341948.1	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 2
NM_002715.4	NP_002706.1	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	1328865	GOA
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	9847399	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: 通过直接分析推断	25438055	GOA
enables protein tyrosine phosphatase activity	IDA IDA: 通过直接分析推断	15525651	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of epithelial to mesenchymal transition	IMP IMP: 通过突变表型推断	20080667	GOA
involved in negative regulation of hippo signaling	IDA IDA: 通过直接分析推断	33633399	GOA
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: 通过突变表型推断	21806946	GOA
involved in peptidyl-threonine dephosphorylation	IDA IDA: 通过直接分析推断	30611118	GOA
involved in peptidyl-threonine dephosphorylation	IMP IMP: 通过突变表型推断	15525651	GOA
involved in positive regulation of protein serine/threonine kinase activity	IMP IMP: 通过突变表型推断	20080667	GOA
involved in protein dephosphorylation	IMP IMP: 通过突变表型推断	33108758	GOA
involved in regulation of G1/S transition of mitotic cell cycle	IDA IDA: 通过直接分析推断	25438055	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of FAR/SIN/STRIPAK complex	IDA IDA: 通过直接分析推断	29063833	GOA
located in membrane raft	IDA IDA: 通过直接分析推断	16258073	GOA
part of protein phosphatase type 2A complex	IDA IDA: 通过直接分析推断	17055435	GOA
part of protein serine/threonine phosphatase complex	IDA IDA: 通过直接分析推断	29063833	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPP2CA 蛋白结构

Metallophos

0
100
200
309 a.a.

蛋白主名

其他名称

serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

PP2A-alpha

PPP2CA 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PPP2CA	P67775	STRN	Homo sapiens	O43815	Anti Tag CoIP	18782753
种属内	PPP2CA	P67775	STRN	Homo sapiens	O43815	TAP	18782753
种属内	PPP2CA	P67775	STRN	Homo sapiens	O43815	Anti Tag CoIP	35271311
种属内	PPP2CA	P67775	STRN	Homo sapiens	O43815	Pull Down	28330616
种属内	PPP2CA	P67775	STRN	Homo sapiens	O43815	Anti Tag CoIP	26496610
种属内	PPP2CA	P67775	IGBP1	Homo sapiens	P78318	Y2H	21988832
种属内	PPP2CA	P67775	IGBP1	Homo sapiens	P78318	Anti Tag CoIP	27880917
种属内	PPP2CA	P67775	IGBP1	Homo sapiens	P78318	Y2H Prey Pooling	32296183
种属内	PPP2CA	P67775	IGBP1	Homo sapiens	P78318	Anti Tag CoIP	26496610
种属内	PPP2CA	P67775	IGBP1	Homo sapiens	P78318	Y2H	9647778
种属内	PPP2CA	P67775	IGBP1	Homo sapiens	P78318	Anti Bait CoIP	23892082
种属内	PPP2CA	P67775	IGBP1	Homo sapiens	P78318	Validated Y2H	32296183
种属内	PPP2CA	P67775	IGBP1	Homo sapiens	P78318	Anti Tag CoIP	18782753
种属内	PPP2CA	P67775	IGBP1	Homo sapiens	P78318	Y2H Array	32296183
种属内	PPP2CA	P67775	IGBP1	Homo sapiens	P78318	TAP	18782753
种属内	PPP2CA	P67775	IGBP1	Homo sapiens	P78318	Anti Tag CoIP	19156129
种属内	PPP2CA	P67775	IGBP1	Homo sapiens	P78318	Anti Tag CoIP	35271311
种属内	PPP2CA	P67775	IGBP1	Homo sapiens	P78318	BioID	28330616
种属内	PPP2CA	P67775	IGBP1	Homo sapiens	P78318	Pull Down	28330616
种属内	PPP2CA	P67775	IGBP1	Homo sapiens	P78318	Anti Tag CoIP	9647778
种属内	PPP2CA	P67775	CLPP	Homo sapiens	Q16740	Y2H Array	32296183
种属内	PPP2CA	P67775	CLPP	Homo sapiens	Q16740	Validated Y2H	32296183
种属内	PPP2CA	P67775	CLPP	Homo sapiens	Q16740	Y2H Prey Pooling	32296183
种属内	PPP2CA	P67775	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Prey Pooling	32296183
种属内	PPP2CA	P67775	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Array	32296183
种属内	PPP2CA	P67775	L3MBTL3	Homo sapiens	Q96JM7-2	Validated Y2H	32296183
种属内	PPP2CA	P67775	PPP2R5C	Homo sapiens	Q13362	Y2H	7592815
种属内	PPP2CA	P67775	PPP2R5C	Homo sapiens	Q13362	Anti Tag CoIP	18782753
种属内	PPP2CA	P67775	PPP2R5C	Homo sapiens	Q13362	TAP	18782753
种属内	PPP2CA	P67775	PPP2R5C	Homo sapiens	Q13362	Anti Tag CoIP	19156129
种属内	PPP2CA	P67775	PPP2R5C	Homo sapiens	Q13362	Anti Tag CoIP	27880917
种属内	PPP2CA	P67775	PPP2R5C	Homo sapiens	Q13362	Pull Down	16456541
种属内	PPP2CA	P67775	PPP2R5C	Homo sapiens	Q13362	Anti Tag CoIP	35271311
种属内	PPP2CA	P67775	PPP2R5C	Homo sapiens	Q13362	Pull Down	28330616
种属内	PPP2CA	P67775	PPP2R5C	Homo sapiens	Q13362	Pull Down	19915589
种属内	PPP2CA	P67775	PPP2R5B	Homo sapiens	Q15173	Anti Tag CoIP	16456541
种属内	PPP2CA	P67775	PPP2R5B	Homo sapiens	Q15173	Anti Tag CoIP	27880917
种属内	PPP2CA	P67775	PPP2R5B	Homo sapiens	Q15173	Anti Tag CoIP	35271311
种属内	PPP2CA	P67775	PPP2R5B	Homo sapiens	Q15173	Anti Tag CoIP	18782753
种属内	PPP2CA	P67775	PPP2R5B	Homo sapiens	Q15173	Anti Tag CoIP	7592815
种属内	PPP2CA	P67775	PPP2R5B	Homo sapiens	Q15173	Pull Down	28330616
种属内	PPP2CA	P67775	IER3	Homo sapiens	P46695	Anti Tag CoIP	16456541
种属内	PPP2CA	P67775	IER3	Homo sapiens	P46695	Pull Down	16456541
种属内	PPP2CA	P67775	TRIM35	Homo sapiens	Q9UPQ4-2	Validated Y2H	32296183
种属内	PPP2CA	P67775	TRIM35	Homo sapiens	Q9UPQ4-2	Y2H Array	32296183
种属内	PPP2CA	P67775	TRIM35	Homo sapiens	Q9UPQ4-2	Y2H Prey Pooling	32296183
种属内	PPP2CA	P67775	STRIP1	Homo sapiens	Q5VSL9	Pull Down	28330616
种属内	PPP2CA	P67775	STRIP1	Homo sapiens	Q5VSL9	Anti Tag CoIP	26496610
种属内	PPP2CA	P67775	STRIP1	Homo sapiens	Q5VSL9	Anti Tag CoIP	18782753
种属内	PPP2CA	P67775	STRIP1	Homo sapiens	Q5VSL9	TAP	18782753
种属内	PPP2CA	P67775	STRIP1	Homo sapiens	Q5VSL9	Anti Tag CoIP	19156129
种属内	PPP2CA	P67775	STRIP1	Homo sapiens	Q5VSL9	Anti Tag CoIP	35271311
种属内	PPP2CA	P67775	C3orf36	Homo sapiens	Q3SXR2	Y2H Prey Pooling	32296183
种属内	PPP2CA	P67775	C3orf36	Homo sapiens	Q3SXR2	Validated Y2H	32296183
种属内	PPP2CA	P67775	C3orf36	Homo sapiens	Q3SXR2	Y2H Array	32296183
种属内	PPP2CA	P67775	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	32296183
种属内	PPP2CA	P67775	VAC14	Homo sapiens	Q08AM6	Validated Y2H	32296183
种属内	PPP2CA	P67775	UBAP2	Homo sapiens	Q5T6F2	Y2H Prey Pooling	32296183
种属内	PPP2CA	P67775	UBAP2	Homo sapiens	Q5T6F2	Validated Y2H	32296183
种属内	PPP2CA	P67775	UBAP2	Homo sapiens	Q5T6F2	Y2H Array	32296183
种属内	PPP2CA	P67775	AKT1	Homo sapiens	P31749	Pull Down	16044149
种属内	PPP2CA	P67775	PPP2R1A	Homo sapiens	P30153	Pull Down	19915589
种属内	PPP2CA	P67775	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	18715871
种属内	PPP2CA	P67775	PPP2R1A	Homo sapiens	P30153	Pull Down	28330616
种属内	PPP2CA	P67775	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	19915589
种属内	PPP2CA	P67775	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	27880917
种属内	PPP2CA	P67775	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	26496610
种属内	PPP2CA	P67775	PPP2R1A	Homo sapiens	P30153	Y2H	8617797
种属内	PPP2CA	P67775	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	18782753
种属内	PPP2CA	P67775	PPP2R1A	Homo sapiens	P30153	TAP	18782753
种属内	PPP2CA	P67775	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	19156129
种属内	PPP2CA	P67775	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	35271311
种属内	PPP2CA	P67775	PPP2R1A	Homo sapiens	P30153	BioID	28330616
种属间	PPP2CA	P67775	Nxn	Mus musculus	P97346	Anti Tag CoIP	16764867
种属间	PPP2CA	P67775	Nxn	Mus musculus	P97346	Pull Down	16764867
种属内	PPP2CA	P67775	PPP2R1B	Homo sapiens	P30154	Anti Tag CoIP	18715871
种属内	PPP2CA	P67775	PPP2R1B	Homo sapiens	P30154	Anti Tag CoIP	35271311
种属内	PPP2CA	P67775	PPP2R1B	Homo sapiens	P30154	Pull Down	28330616
种属内	PPP2CA	P67775	PPP2R1B	Homo sapiens	P30154	Anti Tag CoIP	18782753
种属内	PPP2CA	P67775	PPP2R1B	Homo sapiens	P30154	TAP	18782753
种属内	PPP2CA	P67775	PPP2R1B	Homo sapiens	P30154	Anti Tag CoIP	19156129
种属内	PPP2CA	P67775	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	32296183
种属内	PPP2CA	P67775	TRIP13	Homo sapiens	Q15645	Y2H Array	32296183
种属内	PPP2CA	P67775	TRIP13	Homo sapiens	Q15645	Y2H Pooling	16189514
种属内	PPP2CA	P67775	TRIP13	Homo sapiens	Q15645	Validated Y2H	32296183
种属内	PPP2CA	P67775	RAF1	Homo sapiens	P04049	Anti Tag CoIP	16239230
种属内	PPP2CA	P67775	RAF1	Homo sapiens	P04049	Phosphatase Assay	16239230
种属内	PPP2CA	P67775	PPP2R5A	Homo sapiens	Q15172	Anti Tag CoIP	27880917
种属内	PPP2CA	P67775	PPP2R5A	Homo sapiens	Q15172	Anti Tag CoIP	35271311
种属内	PPP2CA	P67775	PPP2R5A	Homo sapiens	Q15172	Pull Down	28330616
种属内	PPP2CA	P67775	PPP2R5A	Homo sapiens	Q15172	Anti Tag CoIP	26496610
种属内	PPP2CA	P67775	PPP2R5A	Homo sapiens	Q15172	Y2H	7592815
种属内	PPP2CA	P67775	PPP2R5A	Homo sapiens	Q15172	Anti Tag CoIP	18782753
种属内	PPP2CA	P67775	PPP2R5A	Homo sapiens	Q15172	Anti Tag CoIP	7592815
种属间	PPP2CA	P67775	Igbp1	Mus musculus	Q61249	Pull Down	12963337
种属间	PPP2CA	P67775	Igbp1	Mus musculus	Q61249	Competition Binding	12963337
种属间	PPP2CA	P67775	E7	Human papillomavirus	P04020	Pull Down	16044149
种属内	PPP2CA	P67775	IKBKB	Homo sapiens	O14920	Anti Bait CoIP	16126728
种属内	PPP2CA	P67775	IKBKB	Homo sapiens	O14920	GMS	16126728
种属内	PPP2CA	P67775	KISS1R	Homo sapiens	Q969F8	Y2H	18977201
种属间	PPP2CA	P67775	E7	Human papillomavirus	P03129	CoIP	16044149
种属间	PPP2CA	P67775	E7	Human papillomavirus	P03129	Pull Down	16044149
种属内	PPP2CA	P67775	RBL2	Homo sapiens	Q08999	CoIP	15467457
种属内	PPP2CA	P67775	SGO1	Homo sapiens	Q5FBB7	Anti Tag CoIP	35271311
种属内	PPP2CA	P67775	SGO1	Homo sapiens	Q5FBB7	Pull Down	28330616
种属内	PPP2CA	P67775	SGO1	Homo sapiens	Q5FBB7	Anti Tag CoIP	27880917

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Neurodevelopmental Disorder And Language Delay With Or Without Structural Brain Abnormalities

NEDLBA

Alzheimer Disease 15

AD15	Alzheimer'S Disease 15
Alzheimer Disease Without Neurofibrillary Tangles	Alzheimer'S Disease 15, Late Onset
Alzheimer'S Disease Without Neurofibrillary Tangles

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11007	PPP2CA Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	PPP2CA	VGNC	VGNC:33251
Mus musculus	PPP2CA	MGD	MGI:1321159
Felis catus	PPP2CA	VGNC	VGNC:102292
Rattus norvegicus	PPP2CA	RGD	RGD:3380
Others	PPP2CA	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PPP2CA - protein phosphatase 2 catalytic subunit alpha Gene

关于 PPP2CA

功能概要

PPP2CA 基因产物(4)

PPP2CA 蛋白结构

PPP2CA 蛋白互作信息

关联疾病

直系同源

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PPP2CA - protein phosphatase 2 catalytic subunit alpha Gene

关于 PPP2CA

功能概要

PPP2CA 基因产物(4)

PPP2CA 蛋白结构

PPP2CA 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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