IGBP1 - immunoglobulin binding protein 1 Gene

中文名称：免疫球蛋白结合蛋白 1

种属: Homo sapiens

同用名: IBP1; MRXS28; alpha4; ALPHA-4

基因 ID: 3476 | 基因类型: protein coding

关于 IGBP1

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:70,133,447-70,166,324 (from NCBI)

This gene has 2 transcripts (splice variants), 236 orthologues, 1 paralogue and is associated with 4 phenotypes. Ubiquitous expression in ovary (RPKM 49.2), thyroid (RPKM 31.5) and 25 other tissues.

功能概要

B 细胞的增殖和分化依赖于 B 细胞抗原受体 (BCR) 复合物。抗原与特定 B 细胞受体的结合导致通过 BCR 复合物的酪氨酸磷酸化反应，并导致多种信号转导途径。[RefSeq 提供，2008 年 7 月]

The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008]

IGBP1 基因产物(4)

mRNA	Protein	Name
NM_001370192.1	NP_001357121.1	immunoglobulin-binding protein 1 isoform 1
NM_001370193.1	NP_001357122.1	immunoglobulin-binding protein 1 isoform 1
NM_001370194.1	NP_001357123.1	immunoglobulin-binding protein 1 isoform 2
NM_001551.3	NP_001542.1	immunoglobulin-binding protein 1 isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	9647778	GOA
enables protein phosphatase regulator activity	IDA IDA: 通过直接分析推断	9647778	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: 通过突变表型推断	17438131	GOA
involved in negative regulation of stress-activated MAPK cascade	IMP IMP: 通过突变表型推断	17438131	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	17438131	GOA
involved in regulation of microtubule-based movement	IMP IMP: 通过突变表型推断	18949047	GOA
involved in response to interleukin-1	IMP IMP: 通过突变表型推断	17438131	GOA
involved in response to tumor necrosis factor	IMP IMP: 通过突变表型推断	17438131	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IGBP1 蛋白结构

TAP42

0
100
200
300
339 a.a.

蛋白主名

其他名称

immunoglobulin-binding protein 1

B cell signal transduction molecule alpha 4

IGBP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	IGBP1	P78318	PPP2CB	Homo sapiens	P62714	Anti Tag CoIP	26496610
种属内	IGBP1	P78318	PPP4C	Homo sapiens	P60510	Anti Tag CoIP	18715871
种属内	IGBP1	P78318	PPP4C	Homo sapiens	P60510	Anti Tag CoIP	16769727
种属内	IGBP1	P78318	PPP4C	Homo sapiens	P60510	TAP	16085932
种属内	IGBP1	P78318	PPP4C	Homo sapiens	P60510	Anti Tag CoIP	26496610
种属内	IGBP1	P78318	TIPRL	Homo sapiens	O75663	Anti Bait CoIP	23892082
种属内	IGBP1	P78318	MID1	Homo sapiens	O15344	Anti Tag CoIP	26496610
种属内	IGBP1	P78318	HSPB1	Homo sapiens	P04792	Reverse RRS	25277244
种属内	IGBP1	P78318	PPP6C	Homo sapiens	O00743	Anti Tag CoIP	18186651
种属内	IGBP1	P78318	PPP6C	Homo sapiens	O00743	Y2H	9647778
种属内	IGBP1	P78318	PPP6C	Homo sapiens	O00743	TAP	16085932
种属内	IGBP1	P78318	PPP6C	Homo sapiens	O00743	Anti Tag CoIP	26496610
种属内	IGBP1	P78318	PPP6C	Homo sapiens	O00743	Pull Down	9647778
种属内	IGBP1	P78318	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	9647778
种属内	IGBP1	P78318	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	26496610
种属内	IGBP1	P78318	PPP2CA	Homo sapiens	P67775	TAP	16085932
种属内	IGBP1	P78318	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Corpus Callosum, Agenesis Of, With Impaired Intellectual Development, Ocular Coloboma, And Micrognathia

MRXS28	Mental Retardation, X-Linked, Syndromic 28
Intellectual Development Disorder, X-Linked, Syndromic 28	Corpus Callosum, Agenesis Of, With Impaired Intellectual Development, Ocular Coloboma And Micrognathia
Intellectual Developmental Disorder, X-Linked, Syndromic 28	Agenesis Of The Corpus Callosum With Impaired Intellectual Development, Ocular Coloboma And Micrognathia

Corpus Callosum Agenesis-Intellectual Disability-Coloboma-Micrognathia Syndrome

Graham-Cox Syndrome	Corpus Callosum, Agenesis Of, With Mental Retardation, Ocular Coloboma And Micrognathia
Mental Retardation, X-Linked, Syndromic 28	Mrxs28
Agenesis Of The Corpus Callosum-Intellectual Disability-Coloboma-Micrognathia Syndrome	Agenesis, Corpus Callosum, With Mental Retardation, Ocular Coloboma And Micrognathia
Corpus Callosum, Agenesis Of, With Mental Retardation, Ocular Coloboma, And Micrognathia

Barbiturate Abuse

Progressive Multifocal Leukoencephalopathy

Pml	Leukoencephalopathy, Progressive Multifocal
Progressive Multifocal Leukoencephalitis	Leukoencephalopathy Progressive Multifocal
Pml - [Progressive Multifocal Leukoencephalopathy]

Autosomal Dominant Alport Syndrome

Alport Syndrome, Autosomal Dominant	Alport Syndrome Dominant Type
Renal Failure And Sensorineural Hearing Loss	Alport Syndrome, Dominant Type

Autosomal Recessive Alport Syndrome

Alport Syndrome, Recessive Type	Alport Syndrome, Autosomal Recessive
Alport Syndrome Autosomal Recessive	Alport Syndrome Recessive Type
Nephropathy And Deafness

Hemoglobin H Disease

HBH	Hemoglobin H Disease, Nondeletional
Hemoglobin H Disease, Deletional	Alpha-Thalassemia Intermedia
Haemoglobin H Disease	Alpha-Thalassemia, Hemoglobin H Type
Hemoglobin H Disease, Deletional And Nondeletional	Alpha Thalassemia, Haemoglobin H Type
Alpha Thalassemia, Hemoglobin H Type	Haemoglobin H Disease, Deletional
Hbh Disease	Alpha-Thalassemia Hemoglobin H Type
Hemoglobin H Disease Deletional	Hemoglobin H Disease Non-Deletional
Alpha-Thalassemia	Alpha - /- - Or Mutational Forms Of Alpha-Thalassaemia
Alpha Thalassaemia Intermedia

Hypoalphalipoproteinemia, Primary, 2

Apolipoprotein A-I Deficiency	Hypoalphalipoproteinemia, Primary, 2, Autosomal Recessive
Primary Hypoalphalipoproteinemia 2	High Density Lipoprotein Deficiency
Apoa-I Deficiency	Familial Apoa-I Deficiency
Familial Hypoalphalipoproteinemia	FHA2
Apolipoprotein A-I

Alport Syndrome

Hereditary Nephritis	Alport Syndrome, X-Linked
Hemorrhagic Hereditary Nephritis	Congenital Hereditary Hematuria
Hemorrhagic Familial Nephritis	Familial Nephritis
Thin Basement Membrane Disease	Thin Basement Membrane Nephropathy
Hematuria-Nephropathy-Deafness Syndrome	Hematuric Hereditary Nephritis
Hereditary Familial Congenital Hemorrhagic Nephritis	Hereditary Hematuria Syndrome
Hereditary Interstitial Pyelonephritis	Alport Deafness-Nephropathy
Alport Hearing Loss-Nephropathy	Alports Syndrome
Nephritis, Hereditary

Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

Adnfle	Autosomal Dominant Sleep-Related Hypermotor Epilepsy
Enfl	Benign Familial Infantile Seizures 6
Benign Familial Infantile Seizures, 6	Nocturnal Frontal Lobe Epilepsy-4
Enfl1	Epilepsy, Nocturnal Frontal Lobe, 1
Epilepsy, Nocturnal Frontal Lobe, Type 1

Alpha-Thalassemia

Alpha Thalassemia	Alpha Thalassaemia
Alpha Plus Thalassemia	Thalassemia, Alpha-
Thalassemias, Alpha-	A-Thalassemia
Α-Thalassemia	A-THAL
Thalassemia	Alpha Thalassaemia Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06612	IGBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	IGBP1	VGNC	VGNC:54166
Rattus norvegicus	IGBP1	RGD	RGD:62011
Mus musculus	IGBP1	MGD	MGI:1346500

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

IGBP1 - immunoglobulin binding protein 1 Gene

关于 IGBP1

功能概要

IGBP1 基因产物(4)

IGBP1 蛋白结构

IGBP1 蛋白互作信息

关联疾病

直系同源

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IGBP1 - immunoglobulin binding protein 1 Gene

关于 IGBP1

功能概要

IGBP1 基因产物(4)

IGBP1 蛋白结构

IGBP1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z