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  3. TIPRL - TOR signaling pathway regulator Gene

TIPRL - TOR signaling pathway regulator Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TOR 信号通路调节器

种属: Homo sapiens

同用名: TIP; TIP41; TIPRL1

基因 ID: 261726 | 基因类型: protein coding

关于 TIPRL

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:168,178,962-168,202,109 (from NCBI)

This gene has 2 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in endometrium (RPKM 11.7), brain (RPKM 11.6) and 25 other tissues.

功能概要

TIPRL 是蛋白磷酸酶 2A (PP2A) (参见 PPP2CA；MIM 176915) 、PP4 (参见 PPP4C；MIM 602035) 和 PP6 (参见 PPP6C；MIM 612725) 的抑制调节剂 (McConnell 等人，2007 [PubMed 17384681] ) .[OMIM 提供，2010 年 11 月]

TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]

TIPRL 基因产物(2)

mRNA Protein Name
NM_001031800.3 NP_001026970.1 TIP41-like protein isoform 2
NM_152902.5 NP_690866.1 TIP41-like protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16085932 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage checkpoint signaling IMP
IMP: 通过突变表型推断
17384681 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TIPRL 蛋白结构

TIP41

TIP41: TIP41-like family (48 - 225)

  • 0
  • 100
  • 200
  • 272 a.a.
蛋白主名 其他名称

TIP41-like protein

TIP41, TOR signaling pathway regulator-like

TIPRL 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TIPRL O75663 PPP2CB Homo sapiens P62714
Anti Tag CoIP
16085932
种属内
TIPRL O75663 PPP4C Homo sapiens P60510
Anti Bait CoIP
18614045
种属内
TIPRL O75663 PPP4C Homo sapiens P60510
TAP
16085932
种属内
TIPRL O75663 IGBP1 Homo sapiens P78318
Anti Bait CoIP
23892082
种属内
TIPRL O75663 PPP6C Homo sapiens O00743
Anti Tag CoIP
17384681
种属内
TIPRL O75663 PPP2CA Homo sapiens P67775
Anti Tag CoIP
17384681
种属内
TIPRL O75663 PPP2CA Homo sapiens P67775
Anti Bait CoIP
23892082
种属间
TIPRL O75663 Ppp2ca Rattus norvegicus P63331
Anti Tag CoIP
23892082
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Alzheimer Disease 15

AD15

Alzheimer'S Disease 15

Alzheimer Disease Without Neurofibrillary Tangles

Alzheimer'S Disease 15, Late Onset

Alzheimer'S Disease Without Neurofibrillary Tangles
Cardiomyopathy, Dilated, 1e

Left Ventricular Noncompaction 9

Left Ventricular Noncompaction 5

Dilated Cardiomyopathy 1e

Dilated Cardiomyopathy 1s

CMD1E

Cdcd2

Cardiomyopathy, Dilated, 1y

CMD1Y

Cardiomyopathy, Dilated, 1s

CMD1S

Dilated Cardiomyopathy 1y

Dilated Cardiomyopathy With Conduction Defect 2

Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia

Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia

Cardiomyopathy, Dilated, With Conduction Defect 2

Cardiomyopathy Dilated With Conduction Defect Type 2

Cardiomyopathy, Dilated 1e

Cardiomyopathy, Dilated 1s

Cardiomyopathy, Dilated 1y

Left Ventricular Non-Compaction 5

LVNC5

Left Ventricular Non-Compaction 9

LVNC9

Cardiomyopathy, Dilated, Type 1e

Cardiomyopathy, Dilated, Type 1s

Cardiomyopathy, Dilated, Type 1y
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14550 TIPRL Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TIPRL MGD MGI:1915087
Macaca mulatta TIPRL VGNC VGNC:79838
Canis familiaris TIPRL VGNC VGNC:47383
Rattus norvegicus TIPRL RGD RGD:1310442
Felis catus TIPRL VGNC VGNC:107949
Bos taurus TIPRL VGNC VGNC:35878
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