2. Gene
  3. PPP2CA - Ppp2ca protein phosphatase 2 catalytic subunit alpha Gene

PPP2CA - Ppp2ca protein phosphatase 2 catalytic subunit alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Pp2a1

基因 ID: 24672 | 基因类型: protein coding

关于 PPP2CA

功能概要

Enables several functions, including beta-2 Adrenergic Receptor binding activity; Enzyme binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of transport; and regulation of cellular protein metabolic process. Acts upstream of or within regulation of protein autophosphorylation; regulation of protein catabolic process; and regulation of signaling receptor activity. Located in cytosol; postsynaptic density; and terminal bouton. Part of protein Phosphatase type 2A complex. Biomarker of type 2 diabetes mellitus. Orthologous to human PPP2CA (protein Phosphatase 2 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

PPP2CA 基因产物(1)

mRNA Protein Name
NM_017039.2 NP_058735.1 serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-2 adrenergic receptor binding IPI
IPI: 通过物理相互作用推断
20395454 RGD
enables enzyme binding IPI
IPI: 通过物理相互作用推断
18031790 RGD
enables identical protein binding IMP
IMP: 通过突变表型推断
19029245 RGD
enables phosphoprotein phosphatase activity IDA
IDA: 通过直接分析推断
15728831 RGD
enables protein antigen binding IPI
IPI: 通过物理相互作用推断
8065321 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10984483 RGD
enables protein domain specific binding IDA
IDA: 通过直接分析推断
11884620 RGD
enables protein kinase B binding IPI
IPI: 通过物理相互作用推断
11884620 RGD
enables protein kinase binding IDA
IDA: 通过直接分析推断
18832448 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
16899564 RGD
enables protein phosphatase 2A binding IDA
IDA: 通过直接分析推断
11884620 RGD
enables protein phosphatase 2A binding IPI
IPI: 通过物理相互作用推断
11032905 RGD
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
17897622 RGD
enables protein serine/threonine phosphatase activity IDA
IDA: 通过直接分析推断
16519540 RGD
enables protein serine/threonine phosphatase activity IMP
IMP: 通过突变表型推断
10640627 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
11032905 RGD
enables tau protein binding IPI
IPI: 通过物理相互作用推断
11032905 RGD
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
10984483 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cardiac ventricle development IEP
IEP: 通过表达模式推断
10861850 RGD
involved in cellular response to calcium ion IEP
IEP: 通过表达模式推断
18322138 RGD
involved in cellular response to cytokine stimulus IEP
IEP: 通过表达模式推断
14567976 RGD
involved in cellular response to ethanol IEP
IEP: 通过表达模式推断
20224005 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: 通过表达模式推断
18372231 RGD
involved in cellular response to glucose stimulus IEP
IEP: 通过表达模式推断
22509362 RGD
involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
24265448 RGD
involved in cellular response to insulin stimulus IEP
IEP: 通过表达模式推断
11884620 RGD
involved in cellular response to steroid hormone stimulus IEP
IEP: 通过表达模式推断
18079279 RGD
involved in heart development IEP
IEP: 通过表达模式推断
9432115 RGD
involved in negative regulation of calcium ion transmembrane transporter activity IMP
IMP: 通过突变表型推断
15728831 RGD
involved in negative regulation of protein import into nucleus IMP
IMP: 通过突变表型推断
18322138 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
18832448 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
18322138 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
18322138 RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
18322138 RGD
involved in positive regulation of dephosphorylation IMP
IMP: 通过突变表型推断
16884689 RGD
involved in protein dephosphorylation IDA
IDA: 通过直接分析推断
16519540 RGD
acts upstream of or within regulation of protein autophosphorylation IMP
IMP: 通过突变表型推断
19029245 RGD
acts upstream of or within regulation of protein catabolic process IMP
IMP: 通过突变表型推断
19029245 RGD
acts upstream of or within regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
19029245 RGD
acts upstream of or within regulation of signaling receptor activity IMP
IMP: 通过突变表型推断
19029245 RGD
involved in response to lead ion IDA
IDA: 通过直接分析推断
22387731 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protein phosphatase type 2A complex IMP
IMP: 通过突变表型推断
19029245 RGD
located in terminal bouton IDA
IDA: 通过直接分析推断
15728831 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

PP2A-alpha

protein phosphatase 2, catalytic subunit, alpha isozyme

protein phosphatase-2A-alpha

PPP2CA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Ppp2ca P63331 TIPRL Homo sapiens O75663
Anti Tag CoIP
23892082
种属内
Ppp2ca P63331 Dpysl2 Rattus norvegicus P47942
Anti Bait CoIP
20220019
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11007 PPP2CA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens PPP2CA NCBI NCBI:5515
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