PPP6C - protein phosphatase 6 catalytic subunit Gene

中文名称：蛋白磷酸酶 6 催化亚基

种属: Homo sapiens

同用名: PP6; PP6C

基因 ID: 5537 | 基因类型: protein coding

关于 PPP6C

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:125,146,573-125,189,803 (from NCBI)

This gene has 4 transcripts (splice variants), 220 orthologues, 12 paralogues and is associated with 71 phenotypes. Ubiquitous expression in thyroid (RPKM 20.0), fat (RPKM 18.6) and 25 other tissues.

功能概要

该基因编码蛋白磷酸酶的催化亚基，蛋白磷酸酶是调节细胞周期进程的信号通路的一个组成部分。存在编码不同蛋白质同种型的剪接变体。该基因的假基因位于 X 染色体上。[RefSeq 提供，2008 年 7 月]

This gene encodes the catalytic subunit of protein Phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]

PPP6C 基因产物(3)

mRNA	Protein	Name
NM_001123355.2	NP_001116827.1	serine/threonine-protein phosphatase 6 catalytic subunit isoform a
NM_001123369.2	NP_001116841.1	serine/threonine-protein phosphatase 6 catalytic subunit isoform c
NM_002721.5	NP_002712.1	serine/threonine-protein phosphatase 6 catalytic subunit isoform b

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	9647778	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: 通过直接分析推断	32474700	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of cGAS/STING signaling pathway	IDA IDA: 通过直接分析推断	32474700	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPP6C 蛋白结构

Metallophos

0
100
200
305 a.a.

蛋白主名

其他名称

serine/threonine-protein phosphatase 6 catalytic subunit

serine/threonine protein phosphatase catalytic subunit

关联疾病

疾病名称

别名

Skin Melanoma

Cutaneous Melanoma	Malignant Ear Melanoma
Malignant Lip Melanoma	Malignant Lower Limb Melanoma
Malignant Melanoma Of Ear And/Or External Auricular Canal	Malignant Melanoma Of Skin Of Lower Limb
Malignant Melanoma Of Skin Of Trunk Except Scrotum	Malignant Melanoma Of Skin Of Upper Limb
Malignant Neck Melanoma	Malignant Scalp Melanoma
Malignant Trunk Melanoma	Malignant Upper Limb Melanoma
Melanoma, Cutaneous Malignant	Melanoma
Malignant Melanoma Of Skin	Melanoma Nos
Malignant Mole, Meaning Melanoma Of Unspecified Site	Melanoma Of Unspecified Site
Cutaneous Malignant Melanoma	Mm - [Malignant Melanoma]

Lung Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lung	Squamous Cell Lung Carcinoma
Epidermoid Cell Carcinoma Of The Lung	Squamous Cell Lung Cancer

Pineal Parenchymal Tumor Of Intermediate Differentiation

Pineal Parenchymal Tumour Of Intermediate Differentiation	Pineal Parenchymal Tumors Of Intermediate Differentiation
Pptid

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Melanoma, Cutaneous Malignant 1

Familial Melanoma	Melanoma, Cutaneous Malignant, Susceptibility To, 1
Melanoma, Malignant	CMM1
Melanoma, Cutaneous Malignant	Cmm
Familial Atypical Mole-Malignant Melanoma Syndrome	Fammm
Melanoma, Familial	Mlm
Dysplastic Nevus Syndrome, Hereditary	Dns
B-K Mole Syndrome	Melanoma, Cutaneous Malignant, 1
Malignant Melanoma, Cutaneous	Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1
Dysplastic Nevus Syndrome	Cutaneous Melanoma
Familial Atypical Mole Melanoma Syndrome	Hereditary Melanoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11033	PPP6C Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	PPP6C	VGNC	VGNC:102969
Mus musculus	PPP6C	MGD	MGI:1915107
Canis familiaris	PPP6C	VGNC	VGNC:49946
Macaca mulatta	PPP6C	VGNC	VGNC:101481
Bos taurus	PPP6C	VGNC	VGNC:33273
Rattus norvegicus	PPP6C	RGD	RGD:708460

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PPP6C - protein phosphatase 6 catalytic subunit Gene

关于 PPP6C

功能概要

PPP6C 基因产物(3)

PPP6C 蛋白结构

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

PPP6C - protein phosphatase 6 catalytic subunit Gene

关于 PPP6C

功能概要

PPP6C 基因产物(3)

PPP6C 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z