2. Gene
  3. PPP6R3 - protein phosphatase 6 regulatory subunit 3 Gene

PPP6R3 - protein phosphatase 6 regulatory subunit 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白磷酸酶 6 调节亚基 3

种属: Homo sapiens

同用名: SAPL; PP6R3; SAPLa; SAPS3; SAP190; C11orf23

基因 ID: 55291 | 基因类型: protein coding

关于 PPP6R3

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:68,460,752-68,615,334 (from NCBI)

This gene has 26 transcripts (splice variants), 218 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 14.0), testis (RPKM 11.4) and 25 other tissues.

功能概要

蛋白磷酸酶调节亚基，如 SAPS3，通过限制底物特异性、募集底物和决定全酶的细胞内定位来调节蛋白磷酸酶催化亚基的活性。 SAPS3 是蛋白磷酸酶 6 催化亚基 (PPP6C; MIM 612725) 的调节亚基 (Stefansson 和 Brautigan，2006 [PubMed 16769727]) 。[OMIM 提供，2010 年 11 月]

Protein Phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein Phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]

PPP6R3 基因产物(39)

mRNA Protein Name
NM_001164160.2 NP_001157632.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 4
NM_001164161.2 NP_001157633.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 6
NM_001164162.2 NP_001157634.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 1
NM_001164163.2 NP_001157635.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 2
NM_001164164.2 NP_001157636.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 3
NM_001352347.2 NP_001339276.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 7
NM_001352348.2 NP_001339277.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 1
NM_001352350.2 NP_001339279.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 8
NM_001352351.2 NP_001339280.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 9
NM_001352352.2 NP_001339281.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 10
NM_001352353.2 NP_001339282.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 11
NM_001352354.2 NP_001339283.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 12
NM_001352355.2 NP_001339284.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 13
NM_001352356.2 NP_001339285.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 12
NM_001352357.2 NP_001339286.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 14
NM_001352358.2 NP_001339287.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 15
NM_001352359.2 NP_001339288.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 16
NM_001352360.2 NP_001339289.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 17
NM_001352361.2 NP_001339290.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 18
NM_001352362.2 NP_001339291.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 19
NM_001352363.2 NP_001339292.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 2
NM_001352364.2 NP_001339293.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 4
NM_001352365.2 NP_001339294.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 19
NM_001352366.2 NP_001339295.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 23
NM_001352368.2 NP_001339297.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 6
NM_001352369.2 NP_001339298.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 20
NM_001352370.2 NP_001339299.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 21
NM_001352371.2 NP_001339300.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 10
NM_001352372.2 NP_001339301.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 24
NM_001352373.2 NP_001339302.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 17
NM_001352374.2 NP_001339303.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 22
NM_001352375.2 NP_001339304.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 6
NM_001352376.2 NP_001339305.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 8
NM_001352377.2 NP_001339306.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 24
NM_001352378.2 NP_001339307.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 22
NM_001352379.2 NP_001339308.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 4
NM_001352380.2 NP_001339309.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 8
NM_001411030.1 NP_001397959.1 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 25
NM_018312.5 NP_060782.2 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 5
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18186651 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPP6R3 蛋白结构

SAPS

SAPS: SIT4 phosphatase-associated protein (129 - 361)

SAPS

SAPS: SIT4 phosphatase-associated protein (363 - 512)

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  • 873 a.a.
蛋白主名 其他名称

serine/threonine-protein phosphatase 6 regulatory subunit 3

SAPS domain family, member 3

关联疾病

疾病名称 别名
Fasciitis
Acute Cor Pulmonale
Acute Pulmonary Heart Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11036 PPP6R3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PPP6R3 VGNC VGNC:44927
Rattus norvegicus PPP6R3 RGD RGD:1307145
Felis catus PPP6R3 VGNC VGNC:64334
Bos taurus PPP6R3 VGNC VGNC:33275
Macaca mulatta PPP6R3 VGNC VGNC:76246
Mus musculus PPP6R3 MGD MGI:1921807
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