TERF2IP - TERF2 interacting protein Gene

中文名称：TERF2 相互作用蛋白

种属: Homo sapiens

同用名: RAP1; DRIP5

基因 ID: 54386 | 基因类型: protein coding

关于 TERF2IP

Cytogenetic location: 16q23.1 Genomic coordinates (GRCh38): 16:75,647,773-75,657,432 (from NCBI)

This gene has 5 transcripts (splice variants), 188 orthologues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 81.9), adrenal (RPKM 51.2) and 25 other tissues.

功能概要

该基因编码的蛋白质是参与端粒长度调节的复合物的一部分。假基因存在于 5 号和 22 号染色体上。[RefSeq 提供，2010 年 4 月]

The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010]

TERF2IP 基因产物(1)

mRNA	Protein	Name
NM_018975.4	NP_061848.2	telomeric repeat-binding factor 2-interacting protein 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables G-rich strand telomeric DNA binding	IDA IDA: 通过直接分析推断	17694070	GOA
enables phosphatase binding	IPI IPI: 通过物理相互作用推断	23178297	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	14690602	GOA
enables telomeric DNA binding	IDA IDA: 通过直接分析推断	23685356	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in intracellular signal transduction	IMP IMP: 通过突变表型推断	23867755	GOA
involved in negative regulation of protein phosphorylation	IMP IMP: 通过突变表型推断	23178297	GOA
involved in negative regulation of telomere maintenance	IDA IDA: 通过直接分析推断	17055345	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: 通过突变表型推断	23178297	GOA
involved in protection from non-homologous end joining at telomere	IMP IMP: 通过突变表型推断	17499040	GOA
involved in protein localization to chromosome, telomeric region	IMP IMP: 通过突变表型推断	17499040	GOA
involved in regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	23178297	GOA
involved in regulation of telomere maintenance	IMP IMP: 通过突变表型推断	15100233	GOA
involved in telomere capping	IDA IDA: 通过直接分析推断	21852327	GOA
involved in telomere maintenance	IDA IDA: 通过直接分析推断	14565979	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromosome, telomeric region	IDA IDA: 通过直接分析推断	12768206	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	23178297	GOA
part of nuclear telomere cap complex	IDA IDA: 通过直接分析推断	15181449	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17055345	GOA
part of shelterin complex	IDA IDA: 通过直接分析推断	15383534	GOA
part of shelterin complex	IPI IPI: 通过物理相互作用推断	15383534	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TERF2IP 蛋白结构

Myb_DNA-bind_2

Rap1_C

0
100
200
300
399 a.a.

蛋白主名

其他名称

telomeric repeat-binding factor 2-interacting protein 1

TERF2-interacting telomeric protein 1

TERF2IP 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TERF2IP	Q9NYB0	TALDO1	Homo sapiens	P37837	BiFC	21044950
种属内	TERF2IP	Q9NYB0	RBBP9	Homo sapiens	O75884	BiFC	21044950
种属内	TERF2IP	Q9NYB0	SLX4	Homo sapiens	Q8IY92	Confocal	19596235
种属内	TERF2IP	Q9NYB0	TBCA	Homo sapiens	O75347	BiFC	21044950
种属内	TERF2IP	Q9NYB0	SCLY	Homo sapiens	Q96I15	BiFC	21044950
种属内	TERF2IP	Q9NYB0	AKT1	Homo sapiens	P31749	BiFC	21044950
种属内	TERF2IP	Q9NYB0	XRCC6	Homo sapiens	P12956	Anti Tag CoIP	15383534
种属内	TERF2IP	Q9NYB0	XRCC6	Homo sapiens	P12956	BiFC	21044950
种属内	TERF2IP	Q9NYB0	AKR1A1	Homo sapiens	P14550	BiFC	21044950
种属内	TERF2IP	Q9NYB0	FABP2	Homo sapiens	P12104	BiFC	21044950
种属内	TERF2IP	Q9NYB0	PCP4	Homo sapiens	P48539	BiFC	21044950
种属内	TERF2IP	Q9NYB0	NUMA1	Homo sapiens	Q14980	BiFC	21044950
种属内	TERF2IP	Q9NYB0	WDR5	Homo sapiens	P61964	BiFC	21044950
种属内	TERF2IP	Q9NYB0	TERF2	Homo sapiens	Q15554	Anti Tag CoIP	15383534
种属内	TERF2IP	Q9NYB0	PEA15	Homo sapiens	Q15121	BiFC	21044950
种属内	TERF2IP	Q9NYB0	PEA15	Homo sapiens	Q15121	Pull Down	21044950
种属内	TERF2IP	Q9NYB0	UCHL1	Homo sapiens	P09936	BiFC	21044950
种属内	TERF2IP	Q9NYB0	NASP	Homo sapiens	P49321	BiFC	21044950
种属内	TERF2IP	Q9NYB0	TSSC4	Homo sapiens	Q9Y5U2	BiFC	21044950
种属内	TERF2IP	Q9NYB0	TINF2	Homo sapiens	Q9BSI4-3	Pull Down	15383534
种属内	TERF2IP	Q9NYB0	TINF2	Homo sapiens	Q9BSI4-3	Anti Tag CoIP	15383534
种属内	TERF2IP	Q9NYB0	CHMP2B	Homo sapiens	Q9UQN3	BiFC	21044950
种属内	TERF2IP	Q9NYB0	ZNF414	Homo sapiens	Q96IQ9	BiFC	21044950
种属内	TERF2IP	Q9NYB0	AIMP2	Homo sapiens	Q13155	BiFC	21044950
种属内	TERF2IP	Q9NYB0	GAGE5	Homo sapiens	Q13069	BiFC	21044950
种属内	TERF2IP	Q9NYB0	BABAM1	Homo sapiens	Q9NWV8	BiFC	21044950
种属内	TERF2IP	Q9NYB0	GPKOW	Homo sapiens	Q92917	BiFC	21044950
种属内	TERF2IP	Q9NYB0	XAGE2	Homo sapiens	Q96GT9	BiFC	21044950
种属内	TERF2IP	Q9NYB0	MT3	Homo sapiens	P25713	BiFC	21044950

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Melanoma, Cutaneous Malignant 1

Familial Melanoma	Melanoma, Cutaneous Malignant, Susceptibility To, 1
Melanoma, Malignant	CMM1
Melanoma, Cutaneous Malignant	Cmm
Familial Atypical Mole-Malignant Melanoma Syndrome	Fammm
Melanoma, Familial	Mlm
Dysplastic Nevus Syndrome, Hereditary	Dns
B-K Mole Syndrome	Melanoma, Cutaneous Malignant, 1
Malignant Melanoma, Cutaneous	Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1
Dysplastic Nevus Syndrome	Cutaneous Melanoma
Familial Atypical Mole Melanoma Syndrome	Hereditary Melanoma

Dyskeratosis Congenita, Autosomal Recessive 6

DKCB6	Autosomal Recessive Dyskeratosis Congenita 6
Dyskeratosis Congenita, Autosomal Recessive, 6	Dyskeratosis Congenita, Autosomal Recessive, Type 6

Dyskeratosis Congenita, Autosomal Recessive 1

DKCB1	Autosomal Recessive Dyskeratosis Congenita 1
Dyskeratosis Congenita, Autosomal Recessive, 1	Dyskeratosis Congenita, Autosomal Recessive, Type 1

Melanoma-Astrocytoma Syndrome

Melanoma And Neural System Tumor Syndrome	Melanoma Astrocytoma Syndrome
MASTS

Coats Disease

Exudative Retinopathy	Retinal Telangiectasis
Coats' Disease	Leber Miliary Aneurysm
Coats' Syndrome	Congenital Retinal Telangiectasia

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant	Dc
Dkc	Zinsser-Engman-Cole Syndrome
Dyskeratosis Congenita, Autosomal Dominant	Autosomal Dominant Dyskeratosis Congenita
Dkca	Dyskeratosis Congenita Scoggins Type
Zinsser-Cole-Engman Syndrome	X-Linked Dyskeratosis Congenita
Hoyeraal-Hreidarsson Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14374	TERF2IP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	TERF2IP	VGNC	VGNC:49734
Felis catus	TERF2IP	VGNC	VGNC:66085
Mus musculus	TERF2IP	MGD	MGI:1929871
Macaca mulatta	TERF2IP	VGNC	VGNC:79187
Bos taurus	TERF2IP	VGNC	VGNC:50057

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TERF2IP - TERF2 interacting protein Gene

关于 TERF2IP

功能概要

TERF2IP 基因产物(1)

TERF2IP 蛋白结构

TERF2IP 蛋白互作信息

关联疾病

直系同源

热门区域

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TERF2IP - TERF2 interacting protein Gene

关于 TERF2IP

功能概要

TERF2IP 基因产物(1)

TERF2IP 蛋白结构

TERF2IP 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z