WDR5 - WD repeat domain 5 Gene

中文名称：WD 重复域 5

种属: Homo sapiens

同用名: BIG3; SWD3; BIG-3; CFAP89

关于 WDR5

功能概要

该基因编码 WD 重复蛋白家族的一个成员。 WD 重复是大约 40 个氨基酸的最小保守区域，通常由 gly-his 和 trp-asp (GH-WD) 括起来，这可能有助于异源三聚体或多蛋白复合物的形成。该家族的成员参与多种细胞过程，包括细胞周期进程、信号转导、细胞凋亡和基因调控。该蛋白质包含 7 个 WD 重复序列。已经鉴定出编码相同蛋白质的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]