NCOA6 - nuclear receptor coactivator 6 Gene

中文名称：核受体共激活因子 6

种属: Homo sapiens

同用名: NRC; AIB3; ASC2; PRIP; TRBP; RAP250

基因 ID: 23054 | 基因类型: protein coding

关于 NCOA6

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:34,714,774-34,825,651 (from NCBI)

This gene has 9 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in testis (RPKM 8.8), thyroid (RPKM 7.4) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种转录共激活因子，可以与核激素受体相互作用，增强其转录激活因子的功能。这种蛋白质已被证明参与多种受体的激素依赖性共激活，包括前列腺素、类视黄醇、维生素 D3、甲状腺激素和类固醇受体。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2011 年 6 月]

The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]

NCOA6 基因产物(3)

mRNA	Protein	Name
NM_001242539.2	NP_001229468.1	nuclear receptor coactivator 6 isoform 2
NM_001318240.1	NP_001305169.1	nuclear receptor coactivator 6 isoform 1
NM_014071.5	NP_054790.2	nuclear receptor coactivator 6 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables enzyme binding	IPI IPI: 通过物理相互作用推断	12039952	GOA
enables nuclear receptor coactivator activity	IPI IPI: 通过物理相互作用推断	11443112	GOA
enables nuclear thyroid hormone receptor binding	IDA IDA: 通过直接分析推断	11443112	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10866662	GOA
enables transcription coactivator activity	IDA IDA: 通过直接分析推断	10567404	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within DNA damage response	IDA IDA: 通过直接分析推断	17500065	GOA
involved in DNA-templated transcription initiation	IDA IDA: 通过直接分析推断	10567404	GOA
involved in myeloid cell differentiation	IDA IDA: 通过直接分析推断	11302752	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	11443112	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of MLL3/4 complex	IPI IPI: 通过物理相互作用推断	23508102	GOA
part of histone methyltransferase complex	IDA IDA: 通过直接分析推断	17500065	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11443112	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NCOA6 蛋白结构

Nucleic_acid_bd

0
400
800
1200
1600
2063 a.a.

蛋白主名

其他名称

nuclear receptor coactivator 6

NRC RAP250

NCOA6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	NCOA6	Q14686	KMT2C	Homo sapiens	Q8NEZ4	Anti Bait CoIP	12482968
Intra	NCOA6	Q14686	KMT2C	Homo sapiens	Q8NEZ4	Anti Bait CoIP	19433796
Intra	NCOA6	Q14686	KMT2C	Homo sapiens	Q8NEZ4	Anti Bait CoIP	23870121
Intra	NCOA6	Q14686	KMT2C	Homo sapiens	Q8NEZ4	Anti Bait CoIP	19047629
Intra	NCOA6	Q14686	TP53BP1	Homo sapiens	Q12888	Anti Bait CoIP	19433796
Intra	NCOA6	Q14686	ASH2L	Homo sapiens	Q9UBL3	Anti Bait CoIP	12482968
Intra	NCOA6	Q14686	ASH2L	Homo sapiens	Q9UBL3	Anti Bait CoIP	23870121
Intra	NCOA6	Q14686	ASH2L	Homo sapiens	Q9UBL3	Anti Bait CoIP	17500065
Intra	NCOA6	Q14686	ASH2L	Homo sapiens	Q9UBL3	Anti Bait CoIP	17925232
Intra	NCOA6	Q14686	ASH2L	Homo sapiens	Q9UBL3	Anti Bait CoIP	19433796
Intra	NCOA6	Q14686	ASH2L	Homo sapiens	Q9UBL3	Anti Bait CoIP	19047629
Intra	NCOA6	Q14686	WDR5	Homo sapiens	P61964	Anti Bait CoIP	19047629
Intra	NCOA6	Q14686	WDR5	Homo sapiens	P61964	Anti Bait CoIP	23870121
Intra	NCOA6	Q14686	WDR5	Homo sapiens	P61964	Anti Bait CoIP	17500065
Intra	NCOA6	Q14686	WDR5	Homo sapiens	P61964	Anti Bait CoIP	17925232
Intra	NCOA6	Q14686	WDR5	Homo sapiens	P61964	Anti Bait CoIP	19433796
Intra	NCOA6	Q14686	AR	Homo sapiens	P10275	Y2H	14645241
Intra	NCOA6	Q14686	AR	Homo sapiens	P10275	Anti Bait CoIP	14645241
Intra	NCOA6	Q14686	KMT2B	Homo sapiens	Q9UMN6	Anti Bait CoIP	19047629
Intra	NCOA6	Q14686	KMT2B	Homo sapiens	Q9UMN6	Anti Bait CoIP	19433796
Intra	NCOA6	Q14686	TP53BP1	Homo sapiens	Q12888-1	Pull Down	19433796

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Arthrogryposis, Distal, Type 7

Hecht Syndrome	Trismus-Pseudocamptodactyly Syndrome
Distal Arthrogryposis Type 7	Dutch-Kentucky Syndrome
DA7	Hecht-Beals Syndrome
Mouth, Inability To Open Completely, And Short Finger-Flexor Tendons	Mouth, Inability To Completely Open, And Short Finger-Flexor Tendons
Arthrogryposis Distal Type 7	Trismus Pseudocamptodactyly Syndrome
Arthrogryposis, Distal, 7

Kabuki Syndrome 1

Kabuki Syndrome	Niikawa-Kuroki Syndrome
Kabuki Make-Up Syndrome	Kms
KABUK1	Kabuki Make Up Syndrome
Nks	Kabuki Makeup Syndrome
Kabuki Syndrome, Type 1

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09094	NCOA6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	NCOA6	VGNC	VGNC:82194
Bos taurus	NCOA6	VGNC	VGNC:31924
Felis catus	NCOA6	VGNC	VGNC:63742
Canis familiaris	NCOA6	VGNC	VGNC:43663
Mus musculus	NCOA6	MGD	MGI:1929915
Rattus norvegicus	NCOA6	RGD	RGD:620111
Others	NCOA6	NCBI

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