1. Gene
  2. TRAF6 - TNF receptor associated factor 6 Gene

TRAF6 - TNF receptor associated factor 6 Gene

中文名称:TNF 受体相关因子 6

种属: Homo sapiens

同用名: RNF85; MGC:3310

基因 ID: 7189 | 基因类型: protein coding

关于 TRAF6

Cytogenetic location: 11p12 Genomic coordinates (GRCh38): 11:36,483,769-36,510,272 (from NCBI)

This gene has 3 transcripts (splice variants), 210 orthologues, 5 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 5.9), thyroid (RPKM 3.6) and 25 other tissues.

功能概要

该基因编码的蛋白质是 TNF 受体相关因子 (TRAF) 蛋白质家族的成员。 TRAF 蛋白与 TNF 受体超家族成员相关并介导其信号转导。这种蛋白质有一个氨基末端环结构域,其后是四个锌指基序、一个中央卷曲螺旋区域和一个高度保守的羧基末端结构域,称为 TRAF-C 结构域,并介导来自 TNF 受体超家族成员的信号传导,如以及 Toll/IL-1 家族。来自 CD40、TNFSF11/RANCE 和 IL-1 等受体的信号已被证明是由这种蛋白质介导的。这种蛋白质还与各种蛋白激酶相互作用,包括 IRAK1/IRAK、SRC 和 PKCzeta,从而提供不同信号通路之间的联系。这种蛋白质在激活 IkappaB 激酶 (IKK) 以响应促炎细胞因子的 NF-kappaB 通路中起信号转导作用。已发现该蛋白与 UBE2N/UBC13 和 UBE2V1/UEV1A (催化多泛素链形成的泛素结合酶) 的相互作用是该蛋白激活 IKK 所必需的。这种蛋白质还与转化生长因子 (TGF) β 受体复合物相互作用,并且是 JNK 和 p38 激酶的 Smad 独立激活所必需的。由该基因编码的蛋白质是抗病毒先天性和抗原特异性免疫反应的关键分子。[RefSeq 提供,2021 年 11 月]

The protein encoded by this gene is a member of the TNF Receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF Receptor Superfamily. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain and mediates signaling from members of the TNF Receptor Superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, Src and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating Enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. The protein encoded by this gene is a key molecule in Antiviral innate and antigen-specific immune responses. [provided by RefSeq, Nov 2021]

TRAF6 基因产物(2)

mRNA Protein Name
NM_004620.4 NP_004611.1 TNF receptor-associated factor 6
NM_145803.3 NP_665802.1 TNF receptor-associated factor 6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
18093978 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
19465916 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10094049 GOA
enables protein kinase B binding IPI
IPI: 通过物理相互作用推断
19713527 GOA
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
18758450 GOA
enables ubiquitin conjugating enzyme binding IDA
IDA: 通过直接分析推断
23776175 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
15125833 GOA
enables ubiquitin-protein transferase activity EXP
EXP: 通过实验结果推断
15361868 GOA
enables ubiquitin-ubiquitin ligase activity IDA
IDA: 通过直接分析推断
15465037 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in CD40 signaling pathway IDA
IDA: 通过直接分析推断
8910514 GOA
involved in T cell receptor signaling pathway IDA
IDA: 通过直接分析推断
23514740 GOA
involved in T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
15125833 GOA
involved in activation of protein kinase activity IDA
IDA: 通过直接分析推断
17135271 GOA
involved in antiviral innate immune response IDA
IDA: 通过直接分析推断
18984593 GOA
involved in autophagosome assembly IDA
IDA: 通过直接分析推断
23524951 GOA
involved in canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
20038579 GOA
involved in canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
25515214 GOA
involved in cellular response to cytokine stimulus IMP
IMP: 通过突变表型推断
25515214 GOA
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: 通过直接分析推断
23776175 GOA
involved in cytoplasmic pattern recognition receptor signaling pathway IDA
IDA: 通过直接分析推断
20501938 GOA
involved in interleukin-17A-mediated signaling pathway IDA
IDA: 通过直接分析推断
35183823 GOA
involved in interleukin-33-mediated signaling pathway IMP
IMP: 通过突变表型推断
31435003 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
18093978 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
18093978 GOA
involved in non-canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
19675569 GOA
involved in positive regulation of DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
12296995 GOA
involved in positive regulation of JUN kinase activity IDA
IDA: 通过直接分析推断
11751921 GOA
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
11279055 GOA
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
12296995 GOA
involved in positive regulation of T cell cytokine production IMP
IMP: 通过突变表型推断
15125833 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
17135271 GOA
involved in positive regulation of interleukin-2 production IMP
IMP: 通过突变表型推断
15125833 GOA
involved in positive regulation of leukocyte adhesion to vascular endothelial cell IMP
IMP: 通过突变表型推断
25515214 GOA
involved in positive regulation of osteoclast differentiation IDA
IDA: 通过直接分析推断
17135271 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11751921 GOA
involved in positive regulation of transcription regulatory region DNA binding IDA
IDA: 通过直接分析推断
11751921 GOA
involved in protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
19713527 GOA
involved in protein K63-linked ubiquitination IGI
IGI: 通过遗传相互作用推断
17135271 GOA
acts upstream of or within protein autoubiquitination IDA
IDA: 通过直接分析推断
23776175 GOA
involved in protein autoubiquitination IDA
IDA: 通过直接分析推断
17135271 GOA
involved in protein polyubiquitination IDA
IDA: 通过直接分析推断
15125833 GOA
involved in response to interleukin-1 IDA
IDA: 通过直接分析推断
17135271 GOA
involved in toll-like receptor 4 signaling pathway IDA
IDA: 通过直接分析推断
25371197 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
22851693 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
16378096 GOA
is active in extrinsic component of cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
23514740 GOA
located in nucleus IDA
IDA: 通过直接分析推断
18093978 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
11751921 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
18093978 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
23776175 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TRAF6 蛋白结构

zf-C3HC4_2

zf-C3HC4_2: Zinc finger, C3HC4 type (RING finger) (70 - 107)

zf-TRAF

zf-TRAF: TRAF-type zinc finger (151 - 199)

zf-TRAF

zf-TRAF: TRAF-type zinc finger (204 - 261)

MATH

MATH: MATH domain (358 - 500)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 522 a.a.
蛋白主名 其他名称

TNF receptor-associated factor 6

E3 ubiquitin-protein ligase TRAF6

TRAF6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TRAF6 Q9Y4K3 MALT1 Homo sapiens Q9UDY8
Anti Bait CoIP
17948050
Intra TRAF6 Q9Y4K3 UBE2N Homo sapiens P61088
X-Ray Diffraction
19465916
Intra TRAF6 Q9Y4K3 UBE2N Homo sapiens P61088
GMS
19465916
Intra TRAF6 Q9Y4K3 UBE2N Homo sapiens P61088
Y2H
19465916
Intra TRAF6 Q9Y4K3 UBE2N Homo sapiens P61088
Enzymatic Study
19549727
Intra TRAF6 Q9Y4K3 UBE2N Homo sapiens P61088
SPR
19465916
Intra TRAF6 Q9Y4K3 AMBRA1 Homo sapiens Q9C0C7-3
Anti Tag CoIP
23524951
Intra TRAF6 Q9Y4K3 SYK Homo sapiens P43405-2
Y2H Array
32814053
Intra TRAF6 Q9Y4K3 SYK Homo sapiens P43405-2
Y2H Pooling
32814053
Intra TRAF6 Q9Y4K3 SYK Homo sapiens P43405-2
Validated Y2H
32814053
Intra TRAF6 Q9Y4K3 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
25416956
Intra TRAF6 Q9Y4K3 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
32296183
Intra TRAF6 Q9Y4K3 VPS52 Homo sapiens Q8N1B4
Y2H Array
25416956
Intra TRAF6 Q9Y4K3 VPS52 Homo sapiens Q8N1B4
Y2H Array
32296183
Intra TRAF6 Q9Y4K3 EDARADD Homo sapiens Q8WWZ3
Y2H Prey Pooling
25416956
Intra TRAF6 Q9Y4K3 EDARADD Homo sapiens Q8WWZ3
Validated Y2H
25416956
Intra TRAF6 Q9Y4K3 SQSTM1 Homo sapiens Q13501
Anti Tag CoIP
17389358
Intra TRAF6 Q9Y4K3 SQSTM1 Homo sapiens Q13501
Anti Tag CoIP
16874300
Intra TRAF6 Q9Y4K3 SQSTM1 Homo sapiens Q13501
Anti Bait CoIP
16874300
Intra TRAF6 Q9Y4K3 UBC Homo sapiens P0CG48
Anti Tag CoIP
19820695
Intra TRAF6 Q9Y4K3 UBC Homo sapiens P0CG48
Anti Tag CoIP
18239685
Intra TRAF6 Q9Y4K3 UBE2D2 Homo sapiens P62837
Enzymatic Study
19549727
Intra TRAF6 Q9Y4K3 UBE2D3 Homo sapiens P61077
Enzymatic Study
19549727
Intra TRAF6 Q9Y4K3 UBE2D3 Homo sapiens P61077
Anti Bait CoIP
17353931
Intra TRAF6 Q9Y4K3 UBE2D3 Homo sapiens P61077
Y2H Array
19549727
Intra TRAF6 Q9Y4K3 TRAF2 Homo sapiens Q12933
Y2H Array
25416956
Intra TRAF6 Q9Y4K3 TRAF2 Homo sapiens Q12933
Y2H
21516116
Intra TRAF6 Q9Y4K3 IRAK1 Homo sapiens P51617
Anti Tag CoIP
10383454
Intra TRAF6 Q9Y4K3 IRAK1 Homo sapiens P51617
Anti Bait CoIP
12242293
Intra TRAF6 Q9Y4K3 MAP3K7 Homo sapiens O43318
CoIP
10094049
Intra TRAF6 Q9Y4K3 MAP3K7 Homo sapiens O43318
Anti Tag CoIP
12496252
Intra TRAF6 Q9Y4K3 TAB2 Homo sapiens Q9NYJ8
Y2H
21988832
Intra TRAF6 Q9Y4K3 TAB2 Homo sapiens Q9NYJ8
CoIP
11518704
Intra TRAF6 Q9Y4K3 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Intra TRAF6 Q9Y4K3 TRAF1 Homo sapiens Q13077
BFG-2H
27107012
Intra TRAF6 Q9Y4K3 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra TRAF6 Q9Y4K3 TRAF6 Homo sapiens Q9Y4K3
SAXS
19465916
Intra TRAF6 Q9Y4K3 TRAF6 Homo sapiens Q9Y4K3
GMS
19465916
Intra TRAF6 Q9Y4K3 TRAF6 Homo sapiens Q9Y4K3
Y2H
21988832
Intra TRAF6 Q9Y4K3 TRAF6 Homo sapiens Q9Y4K3
Y2H Array
22493164
Intra TRAF6 Q9Y4K3 TRAF6 Homo sapiens Q9Y4K3
X-Ray Diffraction
19465916
Cross TRAF6 Q9Y4K3 a52_vaccw vaccinia virus Q01220
Anti Tag CoIP
15998638
Intra TRAF6 Q9Y4K3 IRAK3 Homo sapiens Q9Y616
Validated Y2H
32296183
Intra TRAF6 Q9Y4K3 IRAK2 Homo sapiens O43187
Anti Tag CoIP
10383454
Intra TRAF6 Q9Y4K3 S100B Homo sapiens P04271
Validated Y2H
32814053
Intra TRAF6 Q9Y4K3 S100B Homo sapiens P04271
Y2H Array
32814053
Intra TRAF6 Q9Y4K3 S100B Homo sapiens P04271
Y2H Pooling
32814053
Intra TRAF6 Q9Y4K3 YES1 Homo sapiens P07947
Validated Y2H
25416956
Intra TRAF6 Q9Y4K3 YES1 Homo sapiens P07947
Y2H Array
25416956
Intra TRAF6 Q9Y4K3 TRAF5 Homo sapiens O00463
Y2H Prey Pooling
25416956
Intra TRAF6 Q9Y4K3 TRAF5 Homo sapiens O00463
Validated Y2H
25416956
Intra TRAF6 Q9Y4K3 TRAF5 Homo sapiens O00463
Y2H Array
22493164
Intra TRAF6 Q9Y4K3 TRAF5 Homo sapiens O00463
Y2H Array
25416956
Intra TRAF6 Q9Y4K3 TRAF5 Homo sapiens O00463
BFG-2H
27107012
Intra TRAF6 Q9Y4K3 TRAF5 Homo sapiens O00463
Y2H
21516116
Intra TRAF6 Q9Y4K3 CD40 Homo sapiens P25942
X-Ray Diffraction
12140561
Intra TRAF6 Q9Y4K3 ZRANB1 Homo sapiens Q9UGI0
Anti Tag CoIP
11463333
Intra TRAF6 Q9Y4K3 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra TRAF6 Q9Y4K3 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra TRAF6 Q9Y4K3 ZNF675 Homo sapiens Q8TD23
Y2H
11751921
Intra TRAF6 Q9Y4K3 ZNF675 Homo sapiens Q8TD23
IF
11751921
Intra TRAF6 Q9Y4K3 TAX1BP1 Homo sapiens Q86VP1
Anti Tag CoIP
18239685
Intra TRAF6 Q9Y4K3 TAX1BP1 Homo sapiens Q86VP1
Anti Tag CoIP
17703191
Intra TRAF6 Q9Y4K3 RUSC1 Homo sapiens Q9BVN2-2
Anti Tag CoIP
19365808
Intra TRAF6 Q9Y4K3 UCHL1 Homo sapiens P09936
Anti Bait CoIP
17353931
Intra TRAF6 Q9Y4K3 UCHL1 Homo sapiens P09936
Validated Y2H
32814053
Intra TRAF6 Q9Y4K3 UCHL1 Homo sapiens P09936
Y2H Array
32814053
Intra TRAF6 Q9Y4K3 UCHL1 Homo sapiens P09936
Y2H Pooling
32814053
Intra TRAF6 Q9Y4K3 TIFA Homo sapiens Q96CG3
Anti Bait CoIP
26068852
Intra TRAF6 Q9Y4K3 TIFA Homo sapiens Q96CG3
Validated Y2H
27107012
Intra TRAF6 Q9Y4K3 POLI Homo sapiens Q9UNA4
Validated Y2H
25416956
Intra TRAF6 Q9Y4K3 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
25416956
Intra TRAF6 Q9Y4K3 USP2 Homo sapiens O75604
Validated Y2H
25416956
Intra TRAF6 Q9Y4K3 UBE2D1 Homo sapiens P51668
Y2H Array
19549727
Intra TRAF6 Q9Y4K3 TRAF3IP2 Homo sapiens O43734
Y2H Prey Pooling
25416956
Intra TRAF6 Q9Y4K3 TRAF3IP2 Homo sapiens O43734
Y2H Array
25416956
Intra TRAF6 Q9Y4K3 TRAF3IP2 Homo sapiens O43734
Y2H
21516116
Intra TRAF6 Q9Y4K3 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra TRAF6 Q9Y4K3 MEOX2 Homo sapiens P50222
Y2H Array
25416956
Intra TRAF6 Q9Y4K3 ULK1 Homo sapiens O75385
Anti Tag CoIP
23524951
Intra TRAF6 Q9Y4K3 SPHK1 Homo sapiens Q9NYA1
Anti Bait CoIP
17124500
Cross TRAF6 Q9Y4K3 UL37 Human herpesvirus 1 P10221
Anti Bait CoIP
18682563
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ectodermal Dysplasia 10a, Hypohidrotic/Hair/Nail Type, Autosomal Dominant

ECTD10A

Hed

Ectodermal Dysplasia 10a

Ectodermal Dysplasia Hypohidrotic Autosomal Dominant

Autosomal Dominant Hypohidrotic Ectodermal Dysplasia

Ectodermal Dysplasia, Hypohidrotic, Autosomal Dominant

Hypohidrotic Ectodermal Dysplasia Autosomal Dominant

Ad-Hed

Autosomal Dominant Anhidrotic Ectodermal Dysplasia

Ectodermal Dysplasia 3

Ed3

Eda3

Ectodermal Dysplasia, Anhidrotic, Autosomal Dominant

Dysplasia, Ectodermal, Type 10a, Hypohidrotic/Hair/Nail, Autosomal Dominant

Dysplasia, Ectodermal, Type 3

Osteopetrosis

Marble Bone Disease

Albers-Schonberg Disease

Osteopetroses

Marble Bones

Osteopetrosis And Related Disorders

Congenital Osteopetrosis

Marble Bone

Albers-Schoenberg Disease

Albers-Schonberg Osteopetrosis

Osteosclerosis Fragilis

Ivory Bones

Incontinentia Pigmenti

Bloch-Sulzberger Syndrome

IP

Incontinentia Pigmenti, Familial Male-Lethal Type

Incontinentia Pigmenti Syndrome

Bloch-Siemens Syndrome

Ip2

Incontinentia Pigmenti, Type Ii, Formerly

Ip2, Formerly

Incontinentia Pigmenti Type 2

Bloch-Siemens-Sulzberger Syndrome

Familial Incontinentia Pigmenti Male-Lethal Type

Familial Incontinentia Pigmenti Type Ii

Incontinentia Pigmenti, Type Ii

Bloch Sulzberger Syndrome

Incontinentia Pigmenti Achromians

Incontinentia Pigmenti Of Bloch-Sulzberger

Nevus Pigmentosus Systematicus

Ectodermal Dysplasia

Congenital Ectodermal Defect

Congenital Ectodermal Dysplasia

Ectodermal Dysplasia Syndrome

Dysplasia, Ectodermal

B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos

Folliculitis
Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos

Brucellosis

Mediterranean Fever

Malta Fever

Undulant Fever

Gibraltar Fever

Bang'S Disease

Maltese Fever

Cyprus Fever

Rock Fever

Brucellosis Infection

Brucella Infection

Immunodeficiency With Hyper-Igm, Type 3

HIGM3

Immunodeficiency With Hyper Igm Type 3

Hyper-Igm Syndrome Type 3

Hyper-Igm Syndrome 3

Hyper-Igm Syndrome Due To Cd40 Deficiency

Cd40 Deficiency

Type 3 Hyper-Igm Immunodeficiency

Hyper Igm Syndrome 3

Immunodeficiency With Hyper-Igm 3

Hyper-Igm Immunodeficiency Type 3

Immunodeficiency, With Hyper Igm, Type 3

Hyper-Igm Immunodeficiency Syndrome, Type 3

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive

Hypohidrotic Ectodermal Dysplasia

Hed

Anhidrotic Ectodermal Dysplasia

Ectodermal Dysplasia, Hypohidrotic

Eda

Christ-Siemens-Touraine Syndrome

ECTD10B

Ectodermal Dysplasia Anhidrotic

Ectodermal Dysplasia, Anhidrotic

Cst Syndrome

Ectodermal Dysplasia Hypohidrotic Autosomal Recessive

Dysplasia, Ectodermal, Type 10b, Hypohidrotic/Hair/Tooth, Autosomal Recessive

Dysplasia, Ectodermal, Hypohidrotic

Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive

Ectodermal Dysplasia 3, Anhidrotic

Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive

Salivary Gland Adenoid Cystic Carcinoma

Cylindroma

Mammary Paget'S Disease

Paget'S Disease

Mammary Paget Disease

Paget'S Disease Of The Breast

Paget Disease Of The Breast

Paget'S Disease Of The Nipple

Paget'S Disease, Mammary

Paget Cell Neoplasm

Paget Disease Of The Nipple

Pagets Disease Mammary

Osteitis Deformans

Ectodermal Dysplasia 1, Hypohidrotic, X-Linked

Christ-Siemens-Touraine Syndrome

XHED

Ectodermal Dysplasia 1

Xlhed

Ed1

Cst Syndrome

Ectodermal Dysplasia 1, Hypohidrotic/Hair/Tooth Type, X-Linked

Ectd1

Ectodermal Dysplasia, Anhidrotic, X-Linked

Eda

Eda1

Hed1

Ectodermal Dysplasia 1, Anhidrotic

X-Linked Anhidrotic Ectodermal Dysplasia

X-Linked Hypohidrotic Ectodermal Dysplasia

Hypohidrotic X-Linked Ectodermal Dysplasia

Ectodermal Dysplasia, Hypohidrotic, 1

Hypohidrotic Ectodermal Dysplasia, X-Linked

Anhidrotic Ectodermal Dysplasia X-Linked

Hypohidrotic Ectodermal Dysplasia X-Linked

Ectodermal Dysplasia 1 Hypohidrotic/Hair/Tooth Type X-Linked

Ectodermal Dysplasia Anhidrotic

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Paget'S Disease Of Bone

Osteitis Deformans

Paget Disease Of Bone

Osseous Paget'S Disease

Paget Disease Of Bone, Familial

Bone Paget Disease

Familial Paget'S Disease Of Bone

Paget'S Bone Disease

Familial Paget Disease Of Bone

Paget Disease, Bone

Pdb

Pagets Bone Disease

Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease

Bone Disease

Bone Diseases

Skeletal Disease

Skeletal Disorder

Disorder Of Skeletal System

Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Anaerobic Meningitis
Immunodeficiency 58

IMD58

Severe Combined Immunodeficiency Due To Carmil2 Deficiency

Combined Immunodeficiency Due To Carmil2 Deficiency

Combined Immunodeficiency Due To Rltpr Deficiency

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma

Gastric Lymphoma, Primary

Lymphoma, Malt, Somatic

Mucosa-Associated Lymphoid Tissue Lymphoma

Extranodal Marginal Zone B-Cell Lymphoma

MALTOMA

Marginal Zone B-Cell Lymphoma

Mucosa-Associated Lymphatic Tissue Lymphoma

Primary Gastric Lymphoma

Gastric Lymphoma

Familial Primary Gastric Lymphoma

Diabetes Mellitus

Diabetes

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Connective Tissue Disease

Connective Tissue Diseases

Connective Tissue Disorder

Abnormality Of Connective Tissue

Disorder Of Connective Tissue

Connective Tissue Disorders

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus TRAF6 VGNC VGNC:81101
Bos taurus TRAF6 VGNC VGNC:36278
Canis familiaris TRAF6 VGNC VGNC:52058
Macaca mulatta TRAF6 VGNC VGNC:101417
Mus musculus TRAF6 MGD MGI:108072
Rattus norvegicus TRAF6 RGD RGD:1306853
Others TRAF6 NCBI