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  2. UBE2N - ubiquitin conjugating enzyme E2 N Gene

UBE2N - ubiquitin conjugating enzyme E2 N Gene

中文名称:泛素结合酶 E2 N

种属: Homo sapiens

同用名: UBC13; UbcH13; UBCHBEN; HEL-S-71; UbcH-ben; UBCHBEN; UBC13

基因 ID: 7334 | 基因类型: protein coding

关于 UBE2N

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:93,405,684-93,441,947 (from NCBI)

This gene has 6 transcripts (splice variants), 89 orthologues and 24 paralogues. Ubiquitous expression in testis (RPKM 18.8), brain (RPKM 12.2) and 25 other tissues.

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶:泛素激活酶或 E1、泛素结合酶或 E2,以及泛素-蛋白质连接酶或 E3。该基因编码 E2 泛素结合酶家族的成员。对小鼠的研究表明,这种蛋白质在 DNA 复制后修复中发挥作用。[RefSeq 提供,2008 年 7 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]

UBE2N 基因产物(1)

mRNA Protein Name
NM_003348.4 NP_003339.1 ubiquitin-conjugating enzyme E2 N
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11473255 GOA
enables ubiquitin binding IDA
IDA: 通过直接分析推断
16122702 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: 通过直接分析推断
35927303 GOA
enables ubiquitin conjugating enzyme activity IMP
IMP: 通过突变表型推断
17349954 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
18410486 GOA
enables ubiquitin-protein transferase activator activity IMP
IMP: 通过突变表型推断
17349954 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
20061386 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of DNA double-strand break processing IMP
IMP: 通过突变表型推断
17349954 GOA
involved in T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
15125833 GOA
involved in antiviral innate immune response IDA
IDA: 通过直接分析推断
35893676 GOA
acts upstream of double-strand break repair via homologous recombination IMP
IMP: 通过突变表型推断
17349954 GOA
involved in negative regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
35927303 GOA
involved in positive regulation of DNA repair IMP
IMP: 通过突变表型推断
16129784 GOA
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
14695475 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
16129784 GOA
involved in positive regulation of double-strand break repair IDA
IDA: 通过直接分析推断
16129784 GOA
involved in positive regulation of intracellular signal transduction IDA
IDA: 通过直接分析推断
11057907 GOA
involved in positive regulation of protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
10089880 GOA
acts upstream of postreplication repair IMP
IMP: 通过突变表型推断
17349954 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
35927303 GOA
involved in protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
16307917 GOA
involved in protein K63-linked ubiquitination IMP
IMP: 通过突变表型推断
25936802 GOA
involved in protein monoubiquitination IMP
IMP: 通过突变表型推断
17349954 GOA
involved in protein polyubiquitination IMP
IMP: 通过突变表型推断
17349954 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of UBC13-MMS2 complex IDA
IDA: 通过直接分析推断
16129784 GOA
part of UBC13-MMS2 complex IPI
IPI: 通过物理相互作用推断
11057907 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
19340006 GOA
located in cytosol IDA
IDA: 通过直接分析推断
16129784 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16129784 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
22797923 GOA
part of ubiquitin conjugating enzyme complex IDA
IDA: 通过直接分析推断
17349954 GOA
part of ubiquitin ligase complex IDA
IDA: 通过直接分析推断
16307917 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

UBE2N 蛋白结构

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (7 - 142)

  • 0
  • 100
  • 152 a.a.
蛋白主名 其他名称

ubiquitin-conjugating enzyme E2 N

E2 ubiquitin-conjugating enzyme N

UBE2N 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
UBE2N P61088 HLTF Homo sapiens Q14527
Pull Down
18719106
种属内
UBE2N P61088 UBE2V1 Homo sapiens Q13404
Ubiquitinase Assay
25260751
种属内
UBE2N P61088 UBE2V1 Homo sapiens Q13404
Pull Down
16307917
种属内
UBE2N P61088 UBE2V1 Homo sapiens Q13404
Y2H
19549727
种属内
UBE2N P61088 UBE2V1 Homo sapiens Q13404
SLCA
11057907
种属间
UBE2N P61088 ORF169b Shigella flexneri Q8VSD5
Deamination
22407319
种属内
UBE2N P61088 RFWD3 Homo sapiens Q6PCD5
Ubiquitinase Assay
25260751
种属内
UBE2N P61088 RNF13 Homo sapiens O43567
Ubiquitinase Assay
25260751
种属内
UBE2N P61088 RNF13 Homo sapiens O43567
Y2H Array
19690564
种属内
UBE2N P61088 ZNRF1 Homo sapiens Q8ND25
TAP
27173435
种属内
UBE2N P61088 ZNRF1 Homo sapiens Q8ND25
Y2H Array
19690564
种属内
UBE2N P61088 RNF182 Homo sapiens Q8N6D2
Ubiquitinase Assay
25260751
种属间
UBE2N P61088 otub-1 Caenorhabditis elegans Q9XVR6
X-Ray Diffraction
22367539
种属间
UBE2N P61088 otub-1 Caenorhabditis elegans Q9XVR6
FPS
22367539
种属内
UBE2N P61088 STUB1 Homo sapiens Q9UNE7
Pull Down
16307917
种属内
UBE2N P61088 STUB1 Homo sapiens Q9UNE7
Ubiquitinase Assay
25260751
种属内
UBE2N P61088 TRAF6 Homo sapiens Q9Y4K3
Y2H Array
19549727
种属内
UBE2N P61088 TRAF6 Homo sapiens Q9Y4K3
TAP
27173435
种属内
UBE2N P61088 TRAF6 Homo sapiens Q9Y4K3
Enzymatic Study
19549727
种属内
UBE2N P61088 RNF11 Homo sapiens Q9Y3C5
Y2H Array
19690564
种属内
UBE2N P61088 RNF11 Homo sapiens Q9Y3C5
Y2H
15231748
种属内
UBE2N P61088 XIAP Homo sapiens P98170
Enzymatic Study
19549727
种属内
UBE2N P61088 XIAP Homo sapiens P98170
Y2H Array
19549727
种属内
UBE2N P61088 XIAP Homo sapiens P98170
Ubiquitinase Assay
25260751
种属内
UBE2N P61088 BIRC3 Homo sapiens Q13489
Y2H Array
19690564
种属内
UBE2N P61088 BIRC3 Homo sapiens Q13489
Ubiquitinase Assay
25260751
种属内
UBE2N P61088 UBE2V2 Homo sapiens Q15819
TAP
27173435
种属内
UBE2N P61088 UBE2V2 Homo sapiens Q15819
Y2H
19549727
种属内
UBE2N P61088 UBE2V2 Homo sapiens Q15819
X-Ray Diffraction
11473255
种属内
UBE2N P61088 LRSAM1 Homo sapiens Q6UWE0
Ubiquitinase Assay
25260751
种属内
UBE2N P61088 LRSAM1 Homo sapiens Q6UWE0
Y2H Array
19690564
种属内
UBE2N P61088 TRIM32 Homo sapiens Q13049
TAP
27173435
种属内
UBE2N P61088 RNF168 Homo sapiens Q8IYW5
Anti Bait CoIP
19203578
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 UBE2N 蛋白

目录号 产品名 蛋白编号 纯度
HY-P79452 UBE2N/Ubc13 Protein, Human (sf9, His, StrepⅡ) P61088 (A2-I152) ≥95%

UBE2N 抗体

目录号 产品名 应用 反应物种
HY-P82233 Ubiquitin Conjugating Enzyme E2 N Antibody (YA1978) WB, IHC-P, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Riddle Syndrome

RIDL

Radiosensitivity-Immunodeficiency-Dysmorphic Features-Learning Difficulties Syndrome

Rnf168 Deficiency

Radiosensitivity, Immunodeficiency, Dysmorphic Facial Features, And Learning Difficulties

Radiosensitivity, Immunodeficiency, Dysmorphic Features, And Learning Difficulties

Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Spinocerebellar Atrophy

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar

Limb-Girdle Muscular Dystrophy

Lgmd

Limb Girdle Muscular Dystrophy

Muscular Dystrophies, Limb-Girdle

Erb'S Muscular Dystrophy

Leyden-Mbius Muscular Dystrophy

Limb-Girdle Syndrome

Myopathic Limb-Girdle Syndrome

Limb Girdle

Muscular Dystrophy Limb-Girdle

Dystrophy, Muscular, Limb-Girdle

Lgmd - [Limb-Girdle Muscular Dystrophy]

Limb Girdle Muscle Dystrophy

Limb-Girdle Myopathy

Angelman Syndrome

AS

Happy Puppet Syndrome

Happy Puppet Syndrome, Formerly

Puppetlike Syndrome

Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus UBE2N MGD MGI:1934835
Rattus norvegicus UBE2N RGD RGD:621096
Macaca mulatta UBE2N VGNC VGNC:100116
Bos taurus UBE2N VGNC VGNC:36590
Others UBE2N NCBI