ZNRF1 - zinc and ring finger 1 Gene

中文名称：锌和无名指 1

种属: Homo sapiens

同用名: NIN283

关于 ZNRF1

功能概要

该基因编码一种在神经细胞分化中起作用的 E3 泛素蛋白连接酶。该基因的过度表达会导致神经突样伸长。编码的蛋白质包含锌指和无名指基序，位于核内体/溶酶体区室中，表明它可能参与泛素介导的蛋白质修饰，以及神经元中的突触小泡膜。[RefSeq 提供，2012 年 2 月]

This gene encodes an E3 ubiquitin-protein Ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012]