UBE2D3 - ubiquitin conjugating enzyme E2 D3 Gene

中文名称：泛素结合酶 E2 D3

种属: Homo sapiens

同用名: UBC4/5; UBCH5C; E2(17)KB3

关于 UBE2D3

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶：泛素激活酶或 E1、泛素结合酶或 E2，以及泛素-蛋白质连接酶或 E3。该基因编码 E2 泛素结合酶家族的成员。这种酶在肿瘤抑制蛋白 p53 的泛素化中起作用，它由 E3 泛素蛋白连接酶诱导。[RefSeq 提供，2017 年 1 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. This Enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein Ligase. [provided by RefSeq, Jan 2017]