UBE2D3 - ubiquitin conjugating enzyme E2 D3 Gene

中文名称：泛素结合酶 E2 D3

种属: Homo sapiens

同用名: UBC4/5; UBCH5C; E2(17)KB3

基因 ID: 7323 | 基因类型: protein coding

关于 UBE2D3

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:102,794,383-102,868,895 (from NCBI)

This gene has 33 transcripts (splice variants), 258 orthologues and 12 paralogues. Ubiquitous expression in bone marrow (RPKM 59.8), thyroid (RPKM 40.1) and 25 other tissues.

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶：泛素激活酶或 E1、泛素结合酶或 E2，以及泛素-蛋白质连接酶或 E3。该基因编码 E2 泛素结合酶家族的成员。这种酶在肿瘤抑制蛋白 p53 的泛素化中起作用，它由 E3 泛素蛋白连接酶诱导。[RefSeq 提供，2017 年 1 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. This Enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein Ligase. [provided by RefSeq, Jan 2017]

UBE2D3 基因产物(10)

mRNA	Protein	Name
NM_001300795.2	NP_001287724.1	ubiquitin-conjugating enzyme E2 D3 isoform 4
NM_003340.6	NP_003331.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181886.3	NP_871615.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181887.3	NP_871616.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181888.3	NP_871617.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181889.2	NP_871618.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181890.3	NP_871619.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181891.3	NP_871620.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181892.4	NP_871621.1	ubiquitin-conjugating enzyme E2 D3 isoform 2
NM_181893.3	NP_871622.1	ubiquitin-conjugating enzyme E2 D3 isoform 3

UBE2D3 蛋白结构

UQ_con

0
100
147 a.a.

蛋白主名

其他名称

ubiquitin-conjugating enzyme E2 D3

(E3-independent) E2 ubiquitin-conjugating enzyme D3

UBE2D3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	UBE2D3	P61077	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
种属内	UBE2D3	P61077	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
种属内	UBE2D3	P61077	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
种属内	UBE2D3	P61077	OTUB1	Homo sapiens	Q96FW1	Validated Y2H	32296183
种属内	UBE2D3	P61077	OTUB1	Homo sapiens	Q96FW1	Y2H Array	32296183
种属内	UBE2D3	P61077	OTUB1	Homo sapiens	Q96FW1	Y2H Prey Pooling	25416956
种属内	UBE2D3	P61077	OTUB1	Homo sapiens	Q96FW1	Y2H Prey Pooling	32296183
种属内	UBE2D3	P61077	OTUB1	Homo sapiens	Q96FW1	Anti Tag CoIP	22124327
种属间	UBE2D3	P61077	sspH2	Salmonella typhimurium	P0CE12	NMR	20133640
种属间	UBE2D3	P61077	sspH2	Salmonella typhimurium	P0CE12	Ubiquitinase Assay	20133640
种属内	UBE2D3	P61077	TRIM39	Homo sapiens	Q9HCM9-2	Validated Y2H	32296183
种属内	UBE2D3	P61077	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Array	32296183
种属内	UBE2D3	P61077	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Prey Pooling	32296183
种属内	UBE2D3	P61077	RNF111	Homo sapiens	Q6ZNA4	Y2H Array	19690564
种属内	UBE2D3	P61077	RNF111	Homo sapiens	Q6ZNA4	Validated Y2H	25416956
种属内	UBE2D3	P61077	RNF25	Homo sapiens	Q96BH1	Y2H Prey Pooling	32296183
种属内	UBE2D3	P61077	RNF25	Homo sapiens	Q96BH1	Validated Y2H	32296183
种属内	UBE2D3	P61077	RNF25	Homo sapiens	Q96BH1	Y2H Array	32296183
种属内	UBE2D3	P61077	RNF115	Homo sapiens	Q9Y4L5	Validated Y2H	32296183
种属内	UBE2D3	P61077	RNF115	Homo sapiens	Q9Y4L5	Y2H Prey Pooling	32296183
种属内	UBE2D3	P61077	RNF115	Homo sapiens	Q9Y4L5	Y2H Array	32296183
种属内	UBE2D3	P61077	RNF115	Homo sapiens	Q9Y4L5	Y2H Array	25416956
种属内	UBE2D3	P61077	RNF115	Homo sapiens	Q9Y4L5	Y2H Array	19690564
种属内	UBE2D3	P61077	ZNRF1	Homo sapiens	Q8ND25	Y2H Array	19549727
种属内	UBE2D3	P61077	ZNRF1	Homo sapiens	Q8ND25	Y2H	19549727
种属内	UBE2D3	P61077	DTX3	Homo sapiens	Q8N9I9	Validated Y2H	32296183
种属内	UBE2D3	P61077	DTX3	Homo sapiens	Q8N9I9	Y2H Array	32296183
种属内	UBE2D3	P61077	DTX3	Homo sapiens	Q8N9I9	Y2H Prey Pooling	32296183
种属内	UBE2D3	P61077	DTX3	Homo sapiens	Q8N9I9	Y2H Array	19549727
种属内	UBE2D3	P61077	MID1	Homo sapiens	O15344	Validated Y2H	25416956
种属内	UBE2D3	P61077	MID1	Homo sapiens	O15344	Y2H Array	32296183
种属内	UBE2D3	P61077	MID1	Homo sapiens	O15344	Y2H Prey Pooling	25416956
种属内	UBE2D3	P61077	MID1	Homo sapiens	O15344	Y2H Prey Pooling	32296183
种属内	UBE2D3	P61077	MID1	Homo sapiens	O15344	Y2H Array	31515488
种属内	UBE2D3	P61077	RNF5	Homo sapiens	Q99942	Y2H Prey Pooling	32296183
种属内	UBE2D3	P61077	RNF5	Homo sapiens	Q99942	Validated Y2H	32296183
种属内	UBE2D3	P61077	RNF5	Homo sapiens	Q99942	Y2H Array	32296183
种属内	UBE2D3	P61077	RNF126	Homo sapiens	Q9BV68	Y2H Array	31515488
种属内	UBE2D3	P61077	RNF126	Homo sapiens	Q9BV68	Y2H Array	19549727
种属内	UBE2D3	P61077	RNF126	Homo sapiens	Q9BV68	Y2H	19549727
种属内	UBE2D3	P61077	RNF126	Homo sapiens	Q9BV68	Y2H Pooling	16189514
种属内	UBE2D3	P61077	RNF11	Homo sapiens	Q9Y3C5	Enzymatic Study	19549727
种属内	UBE2D3	P61077	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	19549727
种属内	UBE2D3	P61077	XIAP	Homo sapiens	P98170	Enzymatic Study	19549727
种属内	UBE2D3	P61077	XIAP	Homo sapiens	P98170	Y2H Array	19549727
种属内	UBE2D3	P61077	TRIM62	Homo sapiens	Q9BVG3	Y2H Prey Pooling	32296183
种属内	UBE2D3	P61077	TRIM62	Homo sapiens	Q9BVG3	Y2H Array	32296183
种属内	UBE2D3	P61077	TRIM62	Homo sapiens	Q9BVG3	Validated Y2H	32296183
种属内	UBE2D3	P61077	RNF2	Homo sapiens	Q99496	Y2H Array	32296183
种属内	UBE2D3	P61077	RNF2	Homo sapiens	Q99496	Y2H Prey Pooling	32296183
种属内	UBE2D3	P61077	RNF2	Homo sapiens	Q99496	Validated Y2H	32296183
种属内	UBE2D3	P61077	TRIM39	Homo sapiens	Q9HCM9	Validated Y2H	25416956
种属内	UBE2D3	P61077	TRIM39	Homo sapiens	Q9HCM9	Y2H Pooling	16189514
种属内	UBE2D3	P61077	TRIM39	Homo sapiens	Q9HCM9	Y2H Array	19549727
种属内	UBE2D3	P61077	TRIM39	Homo sapiens	Q9HCM9	Y2H Array	31515488
种属内	UBE2D3	P61077	TRIM39	Homo sapiens	Q9HCM9	Y2H Prey Pooling	25416956
种属内	UBE2D3	P61077	DTX2	Homo sapiens	Q86UW9	Y2H Array	32296183
种属内	UBE2D3	P61077	DTX2	Homo sapiens	Q86UW9	Y2H Prey Pooling	25416956
种属内	UBE2D3	P61077	DTX2	Homo sapiens	Q86UW9	Y2H Prey Pooling	32296183
种属内	UBE2D3	P61077	DTX2	Homo sapiens	Q86UW9	Validated Y2H	32296183
种属内	UBE2D3	P61077	UBTD1	Homo sapiens	Q9HAC8	Y2H Array	32296183
种属内	UBE2D3	P61077	UBTD1	Homo sapiens	Q9HAC8	Y2H Prey Pooling	32296183
种属内	UBE2D3	P61077	UBTD1	Homo sapiens	Q9HAC8	Validated Y2H	32296183
种属间	UBE2D3	P61077	Dapk3	Mus musculus	O54784	Anti Tag CoIP	18515077

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 UBE2D3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70998	UBE2D3 Protein, Human	AAH66917 (M1-M147)	≥95%

UBE2D3 抗体

目录号	产品名	应用	反应物种
HY-P82588	Ubiquitin Conjugating Enzyme E2 D3 Antibody (YA2333)	WB, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Limb-Girdle Muscular Dystrophy

Lgmd	Limb Girdle Muscular Dystrophy
Muscular Dystrophies, Limb-Girdle	Erb'S Muscular Dystrophy
Leyden-Mbius Muscular Dystrophy	Limb-Girdle Syndrome
Myopathic Limb-Girdle Syndrome	Limb Girdle
Muscular Dystrophy Limb-Girdle	Dystrophy, Muscular, Limb-Girdle
Lgmd - [Limb-Girdle Muscular Dystrophy]	Limb Girdle Muscle Dystrophy
Limb-Girdle Myopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15341	UBE2D3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	UBE2D3	RGD	RGD:619912
Mus musculus	UBE2D3	MGD	MGI:1913355
Felis catus	UBE2D3	VGNC	VGNC:80097
Bos taurus	UBE2D3	VGNC	VGNC:107251
Macaca mulatta	UBE2D3	VGNC	VGNC:82265
Others	UBE2D3	NCBI

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