2. Gene
  3. UBE2D3 - ubiquitin conjugating enzyme E2 D3 Gene

UBE2D3 - ubiquitin conjugating enzyme E2 D3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素结合酶 E2 D3

种属: Homo sapiens

同用名: UBC4/5; UBCH5C; E2(17)KB3

基因 ID: 7323 | 基因类型: protein coding

关于 UBE2D3

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:102,794,383-102,868,895 (from NCBI)

This gene has 33 transcripts (splice variants), 258 orthologues and 12 paralogues. Ubiquitous expression in bone marrow (RPKM 59.8), thyroid (RPKM 40.1) and 25 other tissues.

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶：泛素激活酶或 E1、泛素结合酶或 E2，以及泛素-蛋白质连接酶或 E3。该基因编码 E2 泛素结合酶家族的成员。这种酶在肿瘤抑制蛋白 p53 的泛素化中起作用，它由 E3 泛素蛋白连接酶诱导。[RefSeq 提供，2017 年 1 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. This Enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein Ligase. [provided by RefSeq, Jan 2017]

UBE2D3 基因产物(10)

mRNA Protein Name
NM_001300795.2 NP_001287724.1 ubiquitin-conjugating enzyme E2 D3 isoform 4
NM_003340.6 NP_003331.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181886.3 NP_871615.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181887.3 NP_871616.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181888.3 NP_871617.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181889.2 NP_871618.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181890.3 NP_871619.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181891.3 NP_871620.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181892.4 NP_871621.1 ubiquitin-conjugating enzyme E2 D3 isoform 2
NM_181893.3 NP_871622.1 ubiquitin-conjugating enzyme E2 D3 isoform 3

UBE2D3 蛋白结构

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (5 - 141)

  • 0
  • 100
  • 147 a.a.
蛋白主名 其他名称

ubiquitin-conjugating enzyme E2 D3

(E3-independent) E2 ubiquitin-conjugating enzyme D3

UBE2D3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
UBE2D3 P61077 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
种属内
UBE2D3 P61077 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
种属内
UBE2D3 P61077 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
种属内
UBE2D3 P61077 OTUB1 Homo sapiens Q96FW1
Validated Y2H
32296183
种属内
UBE2D3 P61077 OTUB1 Homo sapiens Q96FW1
Y2H Array
32296183
种属内
UBE2D3 P61077 OTUB1 Homo sapiens Q96FW1
Y2H Prey Pooling
25416956
种属内
UBE2D3 P61077 OTUB1 Homo sapiens Q96FW1
Y2H Prey Pooling
32296183
种属内
UBE2D3 P61077 OTUB1 Homo sapiens Q96FW1
Anti Tag CoIP
22124327
种属间
UBE2D3 P61077 sspH2 Salmonella typhimurium P0CE12
NMR
20133640
种属间
UBE2D3 P61077 sspH2 Salmonella typhimurium P0CE12
Ubiquitinase Assay
20133640
种属内
UBE2D3 P61077 TRIM39 Homo sapiens Q9HCM9-2
Validated Y2H
32296183
种属内
UBE2D3 P61077 TRIM39 Homo sapiens Q9HCM9-2
Y2H Array
32296183
种属内
UBE2D3 P61077 TRIM39 Homo sapiens Q9HCM9-2
Y2H Prey Pooling
32296183
种属内
UBE2D3 P61077 RNF111 Homo sapiens Q6ZNA4
Y2H Array
19690564
种属内
UBE2D3 P61077 RNF111 Homo sapiens Q6ZNA4
Validated Y2H
25416956
种属内
UBE2D3 P61077 RNF25 Homo sapiens Q96BH1
Y2H Prey Pooling
32296183
种属内
UBE2D3 P61077 RNF25 Homo sapiens Q96BH1
Validated Y2H
32296183
种属内
UBE2D3 P61077 RNF25 Homo sapiens Q96BH1
Y2H Array
32296183
种属内
UBE2D3 P61077 RNF115 Homo sapiens Q9Y4L5
Validated Y2H
32296183
种属内
UBE2D3 P61077 RNF115 Homo sapiens Q9Y4L5
Y2H Prey Pooling
32296183
种属内
UBE2D3 P61077 RNF115 Homo sapiens Q9Y4L5
Y2H Array
32296183
种属内
UBE2D3 P61077 RNF115 Homo sapiens Q9Y4L5
Y2H Array
25416956
种属内
UBE2D3 P61077 RNF115 Homo sapiens Q9Y4L5
Y2H Array
19690564
种属内
UBE2D3 P61077 ZNRF1 Homo sapiens Q8ND25
Y2H Array
19549727
种属内
UBE2D3 P61077 ZNRF1 Homo sapiens Q8ND25
Y2H
19549727
种属内
UBE2D3 P61077 DTX3 Homo sapiens Q8N9I9
Validated Y2H
32296183
种属内
UBE2D3 P61077 DTX3 Homo sapiens Q8N9I9
Y2H Array
32296183
种属内
UBE2D3 P61077 DTX3 Homo sapiens Q8N9I9
Y2H Prey Pooling
32296183
种属内
UBE2D3 P61077 DTX3 Homo sapiens Q8N9I9
Y2H Array
19549727
种属内
UBE2D3 P61077 MID1 Homo sapiens O15344
Validated Y2H
25416956
种属内
UBE2D3 P61077 MID1 Homo sapiens O15344
Y2H Array
32296183
种属内
UBE2D3 P61077 MID1 Homo sapiens O15344
Y2H Prey Pooling
25416956
种属内
UBE2D3 P61077 MID1 Homo sapiens O15344
Y2H Prey Pooling
32296183
种属内
UBE2D3 P61077 MID1 Homo sapiens O15344
Y2H Array
31515488
种属内
UBE2D3 P61077 RNF5 Homo sapiens Q99942
Y2H Prey Pooling
32296183
种属内
UBE2D3 P61077 RNF5 Homo sapiens Q99942
Validated Y2H
32296183
种属内
UBE2D3 P61077 RNF5 Homo sapiens Q99942
Y2H Array
32296183
种属内
UBE2D3 P61077 RNF126 Homo sapiens Q9BV68
Y2H Array
31515488
种属内
UBE2D3 P61077 RNF126 Homo sapiens Q9BV68
Y2H Array
19549727
种属内
UBE2D3 P61077 RNF126 Homo sapiens Q9BV68
Y2H
19549727
种属内
UBE2D3 P61077 RNF126 Homo sapiens Q9BV68
Y2H Pooling
16189514
种属内
UBE2D3 P61077 RNF11 Homo sapiens Q9Y3C5
Enzymatic Study
19549727
种属内
UBE2D3 P61077 RNF11 Homo sapiens Q9Y3C5
Y2H Array
19549727
种属内
UBE2D3 P61077 XIAP Homo sapiens P98170
Enzymatic Study
19549727
种属内
UBE2D3 P61077 XIAP Homo sapiens P98170
Y2H Array
19549727
种属内
UBE2D3 P61077 TRIM62 Homo sapiens Q9BVG3
Y2H Prey Pooling
32296183
种属内
UBE2D3 P61077 TRIM62 Homo sapiens Q9BVG3
Y2H Array
32296183
种属内
UBE2D3 P61077 TRIM62 Homo sapiens Q9BVG3
Validated Y2H
32296183
种属内
UBE2D3 P61077 RNF2 Homo sapiens Q99496
Y2H Array
32296183
种属内
UBE2D3 P61077 RNF2 Homo sapiens Q99496
Y2H Prey Pooling
32296183
种属内
UBE2D3 P61077 RNF2 Homo sapiens Q99496
Validated Y2H
32296183
种属内
UBE2D3 P61077 TRIM39 Homo sapiens Q9HCM9
Validated Y2H
25416956
种属内
UBE2D3 P61077 TRIM39 Homo sapiens Q9HCM9
Y2H Pooling
16189514
种属内
UBE2D3 P61077 TRIM39 Homo sapiens Q9HCM9
Y2H Array
19549727
种属内
UBE2D3 P61077 TRIM39 Homo sapiens Q9HCM9
Y2H Array
31515488
种属内
UBE2D3 P61077 TRIM39 Homo sapiens Q9HCM9
Y2H Prey Pooling
25416956
种属内
UBE2D3 P61077 DTX2 Homo sapiens Q86UW9
Y2H Array
32296183
种属内
UBE2D3 P61077 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
25416956
种属内
UBE2D3 P61077 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
32296183
种属内
UBE2D3 P61077 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
种属内
UBE2D3 P61077 UBTD1 Homo sapiens Q9HAC8
Y2H Array
32296183
种属内
UBE2D3 P61077 UBTD1 Homo sapiens Q9HAC8
Y2H Prey Pooling
32296183
种属内
UBE2D3 P61077 UBTD1 Homo sapiens Q9HAC8
Validated Y2H
32296183
种属间
UBE2D3 P61077 Dapk3 Mus musculus O54784
Anti Tag CoIP
18515077
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 UBE2D3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70998 UBE2D3 Protein, Human AAH66917 (M1-M147) ≥95%

关联疾病

疾病名称 别名
Limb-Girdle Muscular Dystrophy

Lgmd

Limb Girdle Muscular Dystrophy

Muscular Dystrophies, Limb-Girdle

Erb'S Muscular Dystrophy

Leyden-Mbius Muscular Dystrophy

Limb-Girdle Syndrome

Myopathic Limb-Girdle Syndrome

Limb Girdle

Muscular Dystrophy Limb-Girdle

Dystrophy, Muscular, Limb-Girdle

Lgmd - [Limb-Girdle Muscular Dystrophy]

Limb Girdle Muscle Dystrophy

Limb-Girdle Myopathy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15341 UBE2D3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus UBE2D3 RGD RGD:619912
Mus musculus UBE2D3 MGD MGI:1913355
Felis catus UBE2D3 VGNC VGNC:80097
Bos taurus UBE2D3 VGNC VGNC:107251
Macaca mulatta UBE2D3 VGNC VGNC:82265
Others UBE2D3 NCBI
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