2. Gene
  3. RNF126 - ring finger protein 126 Gene

RNF126 - ring finger protein 126 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：无名指蛋白 126

种属: Homo sapiens

基因 ID: 55658 | 基因类型: protein coding

关于 RNF126

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:647,526-663,214 (from NCBI)

This gene has 7 transcripts (splice variants), 262 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 15.1), spleen (RPKM 11.1) and 25 other tissues.

功能概要

该基因编码的蛋白质包含一个环指结构域，该结构域存在于多种功能不同的蛋白质中，已知参与蛋白质-蛋白质和蛋白质-DNA 相互作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]

RNF126 基因产物(2)

mRNA Protein Name
NM_001366018.1 NP_001352947.1 E3 ubiquitin-protein ligase RNF126 isoform 2
NM_194460.3 NP_919442.1 E3 ubiquitin-protein ligase RNF126 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14667819 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
23026136 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytoplasm protein quality control by the ubiquitin-proteasome system IMP
IMP: 通过突变表型推断
24981174 GOA
involved in negative regulation of epidermal growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
23418353 GOA
involved in positive regulation of double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
36563124 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
24981174 GOA
involved in protein K27-linked ubiquitination IDA
IDA: 通过直接分析推断
36563124 GOA
involved in protein K29-linked ubiquitination IDA
IDA: 通过直接分析推断
36563124 GOA
involved in protein monoubiquitination IDA
IDA: 通过直接分析推断
23277564 GOA
involved in regulation of cell population proliferation IMP
IMP: 通过突变表型推断
23026136 GOA
involved in retrograde transport, endosome to Golgi IMP
IMP: 通过突变表型推断
24275455 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
24981174 GOA
involved in ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
23026136 GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
IMP: 通过突变表型推断
23418353 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
23026136 GOA
located in nucleus IDA
IDA: 通过直接分析推断
23026136 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RNF126 蛋白结构

zinc_ribbon_9

zinc_ribbon_9: zinc-ribbon (10 - 40)

zf-RING_2

zf-RING_2: Ring finger domain (228 - 270)

  • 0
  • 100
  • 200
  • 311 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase RNF126

RNF126 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RNF126 Q9BV68 BAG6 Homo sapiens P46379-2
Anti Tag CoIP
28514442
种属内
RNF126 Q9BV68 BAG6 Homo sapiens P46379
Anti Tag CoIP
33961781
种属内
RNF126 Q9BV68 BAG6 Homo sapiens P46379
Y2H Array
25416956
种属内
RNF126 Q9BV68 UBE2D1 Homo sapiens P51668
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Friedreich Ataxia

Friedreich Ataxia 1

FRDA

Friedreich Ataxia With Retained Reflexes

Frda1

Fa

Friedreich'S Ataxia

Hereditary Spinal Ataxia

Fa1

Friedreich'S Tabes

Hereditary Spinal Sclerosis

Spinocerebellar Ataxia, Friedreich

Friedreich Spinocerebellar Ataxia

Friedrich'S Ataxia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-163639 BRD4 degrader-2 Inhibitor / 否
HY-RS12045 RNF126 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus RNF126 VGNC VGNC:34018
Canis familiaris RNF126 VGNC VGNC:84866
Rattus norvegicus RNF126 RGD RGD:1306011
Mus musculus RNF126 MGD MGI:1917544
Felis catus RNF126 VGNC VGNC:102685
Macaca mulatta RNF126 VGNC VGNC:76791
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