BAG6 - BAG cochaperone 6 Gene

中文名称：BAG 辅伴侣 6

种属: Homo sapiens

同用名: G3; BAT3; BAG-6; D6S52E

基因 ID: 7917 | 基因类型: protein coding

关于 BAG6

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,639,028-31,652,661 (from NCBI)

This gene has 33 transcripts (splice variants), 1 gene allele and 242 orthologues. Broad expression in testis (RPKM 77.2), spleen (RPKM 25.1) and 25 other tissues.

功能概要

该基因首先被表征为位于人类主要组织相容性复合体 III 类区域内的基因簇的一部分。该基因编码一种被半胱天冬酶 3 切割的核蛋白，并与细胞凋亡的控制有关。此外，该蛋白质与 E1A 结合蛋白 p300 形成复合物，并且是 p53 乙酰化以响应 DNA 损伤所必需的。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by Caspase 3 and is implicated in the control of Apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

BAG6 基因产物(59)

mRNA	Protein	Name
NM_001098534.2	NP_001092004.1	large proline-rich protein BAG6 isoform 2
NM_001199697.2	NP_001186626.1	large proline-rich protein BAG6 isoform 3
NM_001199698.2	NP_001186627.1	large proline-rich protein BAG6 isoform 4
NM_001387940.1	NP_001374869.1	large proline-rich protein BAG6 isoform 4
NM_001387942.1	NP_001374871.1	large proline-rich protein BAG6 isoform 22
NM_001387943.1	NP_001374872.1	large proline-rich protein BAG6 isoform 20
NM_001387944.1	NP_001374873.1	large proline-rich protein BAG6 isoform 21
NM_001387946.1	NP_001374875.1	large proline-rich protein BAG6 isoform 20
NM_001387949.1	NP_001374878.1	large proline-rich protein BAG6 isoform 4
NM_001387951.1	NP_001374880.1	large proline-rich protein BAG6 isoform 25
NM_001387954.1	NP_001374883.1	large proline-rich protein BAG6 isoform 12
NM_001387955.1	NP_001374884.1	large proline-rich protein BAG6 isoform 19
NM_001387956.1	NP_001374885.1	large proline-rich protein BAG6 isoform 4
NM_001387958.1	NP_001374887.1	large proline-rich protein BAG6 isoform 18
NM_001387961.1	NP_001374890.1	large proline-rich protein BAG6 isoform 2
NM_001387963.1	NP_001374892.1	large proline-rich protein BAG6 isoform 15
NM_001387964.1	NP_001374893.1	large proline-rich protein BAG6 isoform 14
NM_001387965.1	NP_001374894.1	large proline-rich protein BAG6 isoform 12
NM_001387982.1	NP_001374911.1	large proline-rich protein BAG6 isoform 14
NM_001387983.1	NP_001374912.1	large proline-rich protein BAG6 isoform 13
NM_001387984.1	NP_001374913.1	large proline-rich protein BAG6 isoform 12
NM_001387985.1	NP_001374914.1	large proline-rich protein BAG6 isoform 11
NM_001387986.1	NP_001374915.1	large proline-rich protein BAG6 isoform 2
NM_001387987.1	NP_001374916.1	large proline-rich protein BAG6 isoform 10
NM_001387988.1	NP_001374917.1	large proline-rich protein BAG6 isoform 6
NM_001387989.1	NP_001374918.1	large proline-rich protein BAG6 isoform 5
NM_001387990.1	NP_001374919.1	large proline-rich protein BAG6 isoform 10
NM_001387991.1	NP_001374920.1	large proline-rich protein BAG6 isoform 7
NM_001387992.1	NP_001374921.1	large proline-rich protein BAG6 isoform 7
NM_001387993.1	NP_001374922.1	large proline-rich protein BAG6 isoform 6
NM_001387994.1	NP_001374923.1	large proline-rich protein BAG6 isoform 5
NM_001387995.1	NP_001374924.1	large proline-rich protein BAG6 isoform 6
NM_001387996.1	NP_001374925.1	large proline-rich protein BAG6 isoform 5
NM_001387997.1	NP_001374926.1	large proline-rich protein BAG6 isoform 21
NM_001387998.1	NP_001374927.1	large proline-rich protein BAG6 isoform 19
NM_001387999.1	NP_001374928.1	large proline-rich protein BAG6 isoform 4
NM_001388000.1	NP_001374929.1	large proline-rich protein BAG6 isoform 4
NM_001388001.1	NP_001374930.1	large proline-rich protein BAG6 isoform 4
NM_001388002.1	NP_001374931.1	large proline-rich protein BAG6 isoform 17
NM_001388003.1	NP_001374932.1	large proline-rich protein BAG6 isoform 16
NM_001388004.1	NP_001374933.1	large proline-rich protein BAG6 isoform 14
NM_001388005.1	NP_001374934.1	large proline-rich protein BAG6 isoform 13
NM_001388006.1	NP_001374935.1	large proline-rich protein BAG6 isoform 12
NM_001388007.1	NP_001374936.1	large proline-rich protein BAG6 isoform 10
NM_001388008.1	NP_001374937.1	large proline-rich protein BAG6 isoform 9
NM_001388009.1	NP_001374938.1	large proline-rich protein BAG6 isoform 8
NM_001388010.1	NP_001374939.1	large proline-rich protein BAG6 isoform 6
NM_001388011.1	NP_001374940.1	large proline-rich protein BAG6 isoform 5
NM_001388012.1	NP_001374941.1	large proline-rich protein BAG6 isoform 23
NM_001388013.1	NP_001374942.1	large proline-rich protein BAG6 isoform 24
NM_001388014.1	NP_001374943.1	large proline-rich protein BAG6 isoform 4
NM_001388015.1	NP_001374944.1	large proline-rich protein BAG6 isoform 2
NM_001388016.1	NP_001374945.1	large proline-rich protein BAG6 isoform 13
NM_001388017.1	NP_001374946.1	large proline-rich protein BAG6 isoform 2
NM_001388018.1	NP_001374947.1	large proline-rich protein BAG6 isoform 2
NM_001388019.1	NP_001374948.1	large proline-rich protein BAG6 isoform 6
NM_001388020.1	NP_001374949.1	large proline-rich protein BAG6 isoform 5
NM_080702.3	NP_542433.1	large proline-rich protein BAG6 isoform 2
NM_080703.3	NP_542434.1	large proline-rich protein BAG6 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	24133212	GOA
enables misfolded protein binding	IDA IDA: 通过直接分析推断	21636303	GOA
enables molecular adaptor activity	EXP EXP: 通过实验结果推断	25713138	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	14667819	GOA
enables receptor ligand activity	IDA IDA: 通过直接分析推断	18852879	GOA
enables ribosome binding	IDA IDA: 通过直接分析推断	20676083	GOA
enables signaling receptor binding	IPI IPI: 通过物理相互作用推断	18852879	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	21636303	GOA
enables ubiquitin-specific protease binding	IPI IPI: 通过物理相互作用推断	24424410	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ERAD pathway	IDA IDA: 通过直接分析推断	23129660	GOA
involved in ERAD pathway	IMP IMP: 通过突变表型推断	26565908	GOA
involved in NK T cell activation	IDA IDA: 通过直接分析推断	18852879	GOA
involved in apoptotic process	IDA IDA: 通过直接分析推断	14960581	GOA
involved in endoplasmic reticulum stress-induced pre-emptive quality control	IMP IMP: 通过突变表型推断	26565908	GOA
involved in immune response-activating cell surface receptor signaling pathway	IDA IDA: 通过直接分析推断	18852879	GOA
involved in internal peptidyl-lysine acetylation	IDA IDA: 通过直接分析推断	17403783	GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: 通过突变表型推断	17403783	GOA
involved in maintenance of unfolded protein	IMP IMP: 通过突变表型推断	21636303	GOA
involved in natural killer cell activation	IDA IDA: 通过直接分析推断	18852879	GOA
involved in positive regulation of ERAD pathway	IMP IMP: 通过突变表型推断	24424410	GOA
involved in post-translational protein targeting to endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	25535373	GOA
involved in proteasomal protein catabolic process	IMP IMP: 通过突变表型推断	26565908	GOA
involved in regulation of protein stability	IDA IDA: 通过直接分析推断	21636303	GOA
involved in tail-anchored membrane protein insertion into ER membrane	IDA IDA: 通过直接分析推断	20676083	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	20676083	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of BAT3 complex	IDA IDA: 通过直接分析推断	20676083	GOA
part of BAT3 complex	IPI IPI: 通过物理相互作用推断	25535373	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	21636303	GOA
located in cytosol	IDA IDA: 通过直接分析推断	17403783	GOA
located in extracellular exosome	IDA IDA: 通过直接分析推断	18852879	GOA
located in membrane	IDA IDA: 通过直接分析推断	23246001	GOA
located in nucleus	IDA IDA: 通过直接分析推断	14960581	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BAG6 蛋白结构

ubiquitin

DUF3538

0
200
400
600
800
1000
1126 a.a.

蛋白主名

其他名称

large proline-rich protein BAG6

BAG family molecular chaperone regulator 6

BAG6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	BAG6	P46379	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
种属间	BAG6	P46379	sars8a	Human SARS coronavirus	Q19QW2	Lumier	22046132
种属间	BAG6	P46379	sars8a	Human SARS coronavirus	Q19QW2	Y2H Pooling	22046132
种属内	BAG6	P46379	SGTA	Homo sapiens	O43765	Y2H	14667819
种属内	BAG6	P46379	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	25416956
种属内	BAG6	P46379	RNF126	Homo sapiens	Q9BV68	Anti Tag CoIP	35271311
种属内	BAG6	P46379	RNF126	Homo sapiens	Q9BV68	Y2H Array	31515488
种属内	BAG6	P46379	RNF126	Homo sapiens	Q9BV68	Y2H	14667819
种属内	BAG6	P46379	RNF126	Homo sapiens	Q9BV68	Validated Y2H	25416956
种属内	BAG6	P46379	RNF126	Homo sapiens	Q9BV68	Anti Tag CoIP	26496610
种属内	BAG6	P46379	RNF126	Homo sapiens	Q9BV68	Y2H Prey Pooling	25416956
种属内	BAG6	P46379	EFEMP1	Homo sapiens	Q12805	Y2H Prey Pooling	25416956
种属内	BAG6	P46379	TFCP2	Homo sapiens	Q12800	Y2H Prey Pooling	25416956
种属内	BAG6	P46379	KLHL12	Homo sapiens	Q53G59	Validated Y2H	25416956
种属内	BAG6	P46379	KLHL12	Homo sapiens	Q53G59	Y2H Pooling	16189514
种属内	BAG6	P46379	KLHL12	Homo sapiens	Q53G59	Y2H Prey Pooling	25416956
种属内	BAG6	P46379	MAVS	Homo sapiens	Q7Z434	Anti Tag CoIP	21903422

种属间: 跨种属相互作用 种属内: 同种属相互作用

BAG6 抗体

目录号	产品名	应用	反应物种
HY-P82506	BAT3 Antibody (YA2251)	WB, ICC/IF	Human, Mouse, Rat

关联疾病

疾病名称

别名

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01347	BAG6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	BAG6	MGD	MGI:1919439
Macaca mulatta	BAG6	VGNC	VGNC:81044
Bos taurus	BAG6	VGNC	VGNC:26410
Rattus norvegicus	BAG6	RGD	RGD:71064
Canis familiaris	BAG6	VGNC	VGNC:38368
Felis catus	BAG6	VGNC	VGNC:60069

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