2. Gene
  3. TFCP2 - transcription factor CP2 Gene

TFCP2 - transcription factor CP2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：转录因子 CP2

种属: Homo sapiens

同用名: LSF; SEF; LBP1C; LSF1D; TFCP2C

基因 ID: 7024 | 基因类型: protein coding

关于 TFCP2

Cytogenetic location: 12q13.12-q13.13 Genomic coordinates (GRCh38): 12:51,093,656-51,173,135 (from NCBI)

This gene has 6 transcripts (splice variants), 215 orthologues and 5 paralogues. Ubiquitous expression in appendix (RPKM 10.8), lymph node (RPKM 10.8) and 25 other tissues.

功能概要

该基因编码的转录因子可结合α-珠蛋白启动子并激活α-珠蛋白基因的转录。编码的蛋白质调节红细胞基因表达，在珠蛋白基因启动子的转录开关中发挥作用，并激活许多其他细胞和病毒基因启动子。该基因产物与某些炎症反应因子相互作用，该基因的多态性可能参与阿尔茨海默病的发病机制。[RefSeq 提供，2010 年 3 月]

This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar 2010]

TFCP2 基因产物(3)

mRNA Protein Name
NM_001173452.2 NP_001166923.1 alpha-globin transcription factor CP2 isoform 2
NM_001173453.2 NP_001166924.1 alpha-globin transcription factor CP2 isoform 3
NM_005653.5 NP_005644.2 alpha-globin transcription factor CP2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16263792 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9685356 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
enables transcription factor binding IPI
IPI: 通过物理相互作用推断
11003662 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mRNA transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11003662 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12089154 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16263792 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
11003662 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
11003662 GOA
part of protein-containing complex IMP
IMP: 通过突变表型推断
16263792 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TFCP2 蛋白结构

CP2

CP2: CP2 transcription factor (56 - 261)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 502 a.a.
蛋白主名 其他名称

alpha-globin transcription factor CP2

SAA3 enhancer factor

TFCP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TFCP2 Q12800 SHTN1 Homo sapiens A0MZ66-7
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 SHTN1 Homo sapiens A0MZ66-7
Validated Y2H
25416956
Intra TFCP2 Q12800 TRAPPC12 Homo sapiens Q53QD4
Validated Y2H
25416956
Intra TFCP2 Q12800 TRAPPC12 Homo sapiens Q53QD4
Y2H Array
25416956
Intra TFCP2 Q12800 TRAPPC12 Homo sapiens Q53QD4
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 EPHA10 Homo sapiens Q5JZY3-3
Y2H Array
25416956
Intra TFCP2 Q12800 NPEPL1 Homo sapiens Q8NDH3-4
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 NPEPL1 Homo sapiens Q8NDH3-4
Validated Y2H
25416956
Intra TFCP2 Q12800 MORF4L1 Homo sapiens Q9UBU8-2
Y2H Array
25416956
Intra TFCP2 Q12800 YJU2 Homo sapiens Q9BW85
Validated Y2H
25416956
Intra TFCP2 Q12800 YJU2 Homo sapiens Q9BW85
Validated Y2H
32296183
Intra TFCP2 Q12800 TDRD1 Homo sapiens Q9BXT4-2
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 TDRD1 Homo sapiens Q9BXT4-2
Validated Y2H
25416956
Intra TFCP2 Q12800 DPH1 Homo sapiens Q9BZG8
Validated Y2H
25416956
Intra TFCP2 Q12800 DNAJC27 Homo sapiens Q9NZQ0
Validated Y2H
32296183
Intra TFCP2 Q12800 DNAJC27 Homo sapiens Q9NZQ0
Validated Y2H
25416956
Intra TFCP2 Q12800 DNAJC27 Homo sapiens Q9NZQ0
Y2H Array
25416956
Intra TFCP2 Q12800 POLL Homo sapiens Q9UGP5-2
Validated Y2H
25416956
Intra TFCP2 Q12800 POLL Homo sapiens Q9UGP5-2
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 MRPL40 Homo sapiens Q9NQ50
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 MRPL40 Homo sapiens Q9NQ50
Validated Y2H
25416956
Intra TFCP2 Q12800 MRPL40 Homo sapiens Q9NQ50
Y2H Array
25416956
Intra TFCP2 Q12800 HAPLN2 Homo sapiens Q9GZV7
Validated Y2H
32296183
Intra TFCP2 Q12800 FANCL Homo sapiens Q9NW38
Y2H Array
25416956
Intra TFCP2 Q12800 FANCL Homo sapiens Q9NW38
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 TSPAN12 Homo sapiens O95859
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 TSPAN12 Homo sapiens O95859
Validated Y2H
25416956
Intra TFCP2 Q12800 TSPAN12 Homo sapiens O95859
Y2H Array
25416956
Intra TFCP2 Q12800 PIMREG Homo sapiens Q9BSJ6
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 ASAP3 Homo sapiens Q8TDY4
Validated Y2H
25416956
Intra TFCP2 Q12800 ASAP3 Homo sapiens Q8TDY4
Y2H Array
25416956
Intra TFCP2 Q12800 UBP1 Homo sapiens Q9NZI7
Y2H Array
20211142
Intra TFCP2 Q12800 UBP1 Homo sapiens Q9NZI7
Anti Tag CoIP
33961781
Intra TFCP2 Q12800 POLR3GL Homo sapiens Q9BT43
Validated Y2H
25416956
Intra TFCP2 Q12800 POLR3GL Homo sapiens Q9BT43
Y2H Array
25416956
Intra TFCP2 Q12800 POLR3GL Homo sapiens Q9BT43
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 C19orf73 Homo sapiens Q9NVV2
Y2H Array
25416956
Intra TFCP2 Q12800 NHSL2 Homo sapiens Q5HYW2
Validated Y2H
32296183
Intra TFCP2 Q12800 PITPNM1 Homo sapiens O00562
Validated Y2H
25416956
Intra TFCP2 Q12800 PITPNM1 Homo sapiens O00562
Y2H Array
25416956
Intra TFCP2 Q12800 PITPNM1 Homo sapiens O00562
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 NABP1 Homo sapiens Q96AH0
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 NABP1 Homo sapiens Q96AH0
Validated Y2H
25416956
Intra TFCP2 Q12800 PLCB1 Homo sapiens Q9NQ66
Y2H Array
25416956
Intra TFCP2 Q12800 BAG6 Homo sapiens P46379
Y2H Array
25416956
Intra TFCP2 Q12800 BAG6 Homo sapiens P46379
Validated Y2H
25416956
Intra TFCP2 Q12800 PPP3R2 Homo sapiens Q96LZ3
Validated Y2H
25416956
Intra TFCP2 Q12800 PPP3R2 Homo sapiens Q96LZ3
Y2H Array
25416956
Intra TFCP2 Q12800 PPP3R2 Homo sapiens Q96LZ3
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 PPIG Homo sapiens Q13427
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 PPIG Homo sapiens Q13427
Validated Y2H
25416956
Intra TFCP2 Q12800 PHF1 Homo sapiens O43189
Validated Y2H
25416956
Intra TFCP2 Q12800 PHF1 Homo sapiens O43189
Y2H
21516116
Intra TFCP2 Q12800 MRPL11 Homo sapiens Q9Y3B7
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 MRPL11 Homo sapiens Q9Y3B7
Y2H Array
25416956
Intra TFCP2 Q12800 RBMS1 Homo sapiens P29558
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 ZCCHC10 Homo sapiens Q8TBK6
Y2H Array
31515488
Intra TFCP2 Q12800 ZCCHC10 Homo sapiens Q8TBK6
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 ZCCHC10 Homo sapiens Q8TBK6
Validated Y2H
25416956
Intra TFCP2 Q12800 EIF5B Homo sapiens Q8N5A0
Validated Y2H
25416956
Intra TFCP2 Q12800 ADPRH Homo sapiens P54922
Y2H Array
25416956
Intra TFCP2 Q12800 TCEA2 Homo sapiens Q15560
Validated Y2H
25416956
Intra TFCP2 Q12800 TCEA2 Homo sapiens Q15560
Y2H Array
25416956
Intra TFCP2 Q12800 CBX8 Homo sapiens Q9HC52
Y2H Array
25416956
Intra TFCP2 Q12800 CBX8 Homo sapiens Q9HC52
Validated Y2H
25416956
Intra TFCP2 Q12800 CBX8 Homo sapiens Q9HC52
Validated Y2H
32296183
Intra TFCP2 Q12800 STMN2 Homo sapiens Q93045
Y2H Array
25416956
Intra TFCP2 Q12800 PPP1R1B Homo sapiens Q9UD71
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 PPP1R1B Homo sapiens Q9UD71
Validated Y2H
25416956
Intra TFCP2 Q12800 SDCBP Homo sapiens O00560
Validated Y2H
25416956
Intra TFCP2 Q12800 TLK1 Homo sapiens Q9UKI8
Validated Y2H
32296183
Intra TFCP2 Q12800 FBXL18 Homo sapiens Q96D16
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 ZCCHC12 Homo sapiens Q6PEW1
Validated Y2H
25416956
Intra TFCP2 Q12800 ZCCHC12 Homo sapiens Q6PEW1
Y2H Array
25416956
Intra TFCP2 Q12800 GPANK1 Homo sapiens O95872
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 GPANK1 Homo sapiens O95872
Validated Y2H
25416956
Intra TFCP2 Q12800 GPANK1 Homo sapiens O95872
Y2H Array
25416956
Intra TFCP2 Q12800 PSMD5 Homo sapiens Q16401
Validated Y2H
25416956
Intra TFCP2 Q12800 PSMD5 Homo sapiens Q16401
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 PSMD5 Homo sapiens Q16401
Y2H Array
25416956
Intra TFCP2 Q12800 EAF1 Homo sapiens Q96JC9
Y2H Array
25416956
Intra TFCP2 Q12800 EAF1 Homo sapiens Q96JC9
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 SUMO1 Homo sapiens P63165
Validated Y2H
25416956
Intra TFCP2 Q12800 SUMO1 Homo sapiens P63165
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 UBE2I Homo sapiens P63279
Validated Y2H
27107012
Intra TFCP2 Q12800 UBE2I Homo sapiens P63279
BFG-2H
27107012
Intra TFCP2 Q12800 CDC73 Homo sapiens Q6P1J9
Y2H Array
25416956
Intra TFCP2 Q12800 CDC73 Homo sapiens Q6P1J9
Validated Y2H
25416956
Intra TFCP2 Q12800 IRAK1BP1 Homo sapiens Q5VVH5
Validated Y2H
25416956
Intra TFCP2 Q12800 MOB3C Homo sapiens Q70IA8
Y2H Prey Pooling
25416956
Intra TFCP2 Q12800 MOB3C Homo sapiens Q70IA8
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spindle Cell Rhabdomyosarcoma
Pleomorphic Rhabdomyosarcoma

Adult Pleomorphic Rhabdomyosarcoma

Anaplastic Rhabdomyosarcoma

Pleomorphic Rhabdomyosarcoma, Adult Type
Glanders

Farcy Pipes

Infection Due To Pseudomonas Mallei

Burkholderia Mallei

Burkholderia Mallei Infection

Equina

Equine Glanders

Farcy

Farcy Buds

Farcy Cords

Infection Due To Actinobacillus Mallei

Infection Due To Malleomyces Mallei

Maliasmus

Malleus

Farce

Actinobacillosis

Actinobacillus Infection
Colorectal Cancer, Hereditary Nonpolyposis, Type 2

HNPCC2

Fcc2

Coca2

Hereditary Nonpolyposis Colorectal Cancer Type 2

Colon Cancer, Familial Nonpolyposis, Type 2

Familial Nonpolyposis Colon Cancer Type 2

Hereditary Non-Polyposis Colorectal Cancer 2

Cancer, Colorectal, Nonpolyposis, Hereditary, Type 2
Lynch Syndrome I

Lynch Syndrome 1

Colorectal Cancer, Hereditary Nonpolyposis, Type 1

HNPCC1

Fcc1

Lynch Syndrome Ii

Colon Cancer, Familial Nonpolyposis, Type 1

Coca1

Familial Nonpolyposis Colon Cancer Type 1

Hereditary Nonpolyposis Colorectal Cancer Type 1

Hereditary Non-Polyposis Colorectal Cancer 1

Hereditary Non-Polyposis Colorectal Cancer 3

Hnpcc3

Lynch Cancer Family Syndrome

Lynch Syndrome

Lynch Syndrome Type I

Lynch Syndrome Type Ii

Cancer, Colorectal, Nonpolyposis, Hereditary, Type 1

Hereditary Nonpolyposis Colorectal Cancer

Colorectal Cancer, Hereditary Nonpolyposis, Type 3

Hereditary Non-Polyposis Colon Cancer Type 2
Embryonal Rhabdomyosarcoma

Rhabdomyosarcoma, Embryonal

Rhabdomyosarcoma Embryonal

Botryoid Rhabdomyosarcoma

Erms

Spindle Cell Rhabdomyosarcomas
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12834A MK2-IN-1 hydrochloride Inhibitor 98.36% 否
HY-12834 MK2-IN-1 Inhibitor 99.04% 否
HY-162934 TFCP2L1-IN-1 Inducer / 否
HY-RS14415 TFCP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14416 TFCP2L1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TFCP2 MGD MGI:98509
Macaca mulatta TFCP2 VGNC VGNC:78323
Felis catus TFCP2 VGNC VGNC:66113
Rattus norvegicus TFCP2 RGD RGD:1306738
Canis familiaris TFCP2 VGNC VGNC:47290
Bos taurus TFCP2 VGNC VGNC:35784
Others TFCP2 NCBI
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