TSPAN12 - tetraspanin 12 Gene

中文名称：四跨膜蛋白 12

种属: Homo sapiens

同用名: EVR5; NET2; NET-2; TM4SF12

基因 ID: 23554 | 基因类型: protein coding

关于 TSPAN12

Cytogenetic location: 7q31.31 Genomic coordinates (GRCh38): 7:120,787,320-120,858,335 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues, 32 paralogues and is associated with 2 phenotypes. Broad expression in kidney (RPKM 32.8), adrenal (RPKM 28.5) and 21 other tissues.

功能概要

由该基因编码的蛋白质是跨膜 4 超家族的成员，也称为四跨膜蛋白家族。这些成员中的大多数是细胞表面蛋白，其特征在于存在四个疏水结构域。这些蛋白质介导在细胞发育、活化、生长和运动的调节中起作用的信号转导事件。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

TSPAN12 基因产物(1)

mRNA	Protein	Name
NM_012338.4	NP_036470.1	tetraspanin-12

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	19587294	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TSPAN12 蛋白结构

Tetraspannin

0
100
200
305 a.a.

蛋白主名

其他名称

tetraspanin-12

tetraspan NET-2

TSPAN12 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TSPAN12	O95859	TMEM182	Homo sapiens	Q6ZP80	Validated Y2H	32296183
种属内	TSPAN12	O95859	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
种属内	TSPAN12	O95859	MARCHF2	Homo sapiens	Q9P0N8	Validated Y2H	32296183
种属内	TSPAN12	O95859	TEX264	Homo sapiens	Q9Y6I9	Validated Y2H	32296183
种属内	TSPAN12	O95859	CTXN3	Homo sapiens	Q4LDR2	Validated Y2H	32296183
种属内	TSPAN12	O95859	ADAM10	Homo sapiens	O14672	Anti Bait CoIP	19587294
种属内	TSPAN12	O95859	ADAM10	Homo sapiens	O14672	Anti Tag CoIP	19587294
种属内	TSPAN12	O95859	O14672-PRO_0000029067	Homo sapiens	O14672-PRO_0000029067	Anti Tag CoIP	19587294
种属内	TSPAN12	O95859	RNF152	Homo sapiens	Q8N8N0	Validated Y2H	32296183
种属内	TSPAN12	O95859	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
种属内	TSPAN12	O95859	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183
种属内	TSPAN12	O95859	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183
种属内	TSPAN12	O95859	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
种属内	TSPAN12	O95859	EMP3	Homo sapiens	P54852	Validated Y2H	32296183
种属内	TSPAN12	O95859	RFT1	Homo sapiens	Q96AA3	Validated Y2H	32296183
种属内	TSPAN12	O95859	IGFBP5	Homo sapiens	P24593	Validated Y2H	32296183
种属内	TSPAN12	O95859	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Exudative Vitreoretinopathy 5

EVR5	Vitreoretinopathy, Exudative 5
Vitreoretinopathy, Exudative, Type 5

Vitreoretinopathy

Persistent Hyperplastic Primary Vitreous, Autosomal Recessive

PHPVAR	Retinal Nonattachment, Nonsyndromic Congenital
Rnanc	Persistent Fetal Vasculature
Retinal Nonattachment And Falciform Detachment	Congenital Non-Syndromic Retinal Non-Attachment
Ncrna	Retinal Detachment Congenital
Retinal Non-Attachment And Falciform Detachment	Vitreous, Primary, Hyperplastic, Persistent, Autosomal Recessive

Vitreoretinal Degeneration

Norrie Disease

Atrophia Bulborum Hereditaria	Episkopi Blindness
Pseudoglioma	ND
Norrie-Warburg Disease	Anderson-Warburg Syndrome
Fetal Iritis Syndrome	Norrie Syndrome
Norrie-Warburg Syndrome	Ndp
Congenital Progressive Oculo-Acoustico-Cerebral Degeneration	Norrie'S Disease
Oligophrenia Microphthalmus	Pseudoglioma Congenita
Whitnall-Norman Syndrome

Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy	Fevr
Criswick-Schepens Syndrome	Exudative Vitreoretinopathy, Familial
Vitreoretinopathy, Exudative )	Exudative Vitreoretinopathy 1

Retinal Detachment

Retinal Detachments	Rhegmatogenous Retinal Detachment
Ruptured Retina With Detachment	Retinal Hole With Detachment

Leukocoria

Leucocoria

Retinal Telangiectasia

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Exudative Vitreoretinopathy 1

Retinopathy Of Prematurity	Retrolental Fibroplasia
EVR1	Criswick-Schepens Syndrome
Rop	Exudative Vitreoretinopathy, Familial, Autosomal Dominant
Fevr, Autosomal Dominant	Premature Retinopathy
Vitreoretinopathy, Exudative 1	Autosomal Dominant Familial Exudative Vitreoretinopathy
Fevr	Vitreoretinopathy, Exudative, Type 1
Retinopathy Of Prematurity Nos	Rlf- [Retrolental Fibroplasia]
Rop - [Retinopathy Of Prematurity]	Terry Syndrome

Persistent Hyperplastic Primary Vitreous

Congenital Retinal Detachment	Ncrna Disease
Non-Syndromic Congenital Retinal Non-Attachment	Pfvs
Phpv	Persistent Fetal Vasculature Syndrome

Coats Disease

Exudative Retinopathy	Retinal Telangiectasis
Coats' Disease	Leber Miliary Aneurysm
Coats' Syndrome	Congenital Retinal Telangiectasia

Peripheral Retinal Degeneration

Peripheral Degeneration Of Retina	Degeneration Of Retina Nos
Reticular Retinal Degeneration	Retinal Degeneration

Hypotropia

Retinal Vascular Disease

Retinal Vascular	Retinal Vascular Disorder
Retina Circulation Disorder

Vitreoretinal Dystrophy

Vitreoretinal Dystrophies

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15160	TSPAN12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	TSPAN12	MGD	MGI:1889818
Macaca mulatta	TSPAN12	VGNC	VGNC:79328
Rattus norvegicus	TSPAN12	RGD	RGD:1311102
Felis catus	TSPAN12	VGNC	VGNC:66626
Bos taurus	TSPAN12	VGNC	VGNC:36427
Canis familiaris	TSPAN12	VGNC	VGNC:47912

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