2. Gene
  3. ADAM10 - ADAM metallopeptidase domain 10 Gene

ADAM10 - ADAM metallopeptidase domain 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ADAM 金属肽酶结构域 10

种属: Homo sapiens

同用名: RAK; kuz; AD10; AD18; MADM; CD156c; CDw156; HsT18717

基因 ID: 102 | 基因类型: protein coding

关于 ADAM10

Cytogenetic location: 15q21.3 Genomic coordinates (GRCh38): 15:58,588,809-58,749,707 (from NCBI)

This gene has 17 transcripts (splice variants), 371 orthologues, 20 paralogues and is associated with 3 phenotypes. Ubiquitous expression in urinary bladder (RPKM 30.9), thyroid (RPKM 26.8) and 25 other tissues.

功能概要

ADAM 家族的成员是具有独特结构的细胞表面蛋白，具有潜在的粘附和蛋白酶结构域。该基因编码 ADAM 家族成员，可切割许多蛋白质，包括 TNF-α 和 E-钙粘蛋白。交替剪接导致编码不同蛋白质的多个转录变体，这些蛋白质可能经历相似的加工过程。[RefSeq 提供，2016 年 2 月]

Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and Protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]

ADAM10 基因产物(2)

mRNA Protein Name
NM_001110.4 NP_001101.1 disintegrin and metalloproteinase domain-containing protein 10 isoform 1 preproprotein
NM_001320570.2 NP_001307499.1 disintegrin and metalloproteinase domain-containing protein 10 isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables endopeptidase activity IMP
IMP: 通过突变表型推断
24990881 GOA
enables metalloendopeptidase activity IDA
IDA: 通过直接分析推断
18676862 GOA
enables metalloendopeptidase activity IMP
IMP: 通过突变表型推断
19114711 GOA
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process IMP
IMP: 通过突变表型推断
28164773 GOA
enables metallopeptidase activity IDA
IDA: 通过直接分析推断
12475894 GOA
enables metallopeptidase activity IMP
IMP: 通过突变表型推断
12535668 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10527948 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
25349418 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in amyloid precursor protein catabolic process IMP
IMP: 通过突变表型推断
28164773 GOA
involved in constitutive protein ectodomain proteolysis IDA
IDA: 通过直接分析推断
12714508 GOA
acts upstream of or within membrane protein ectodomain proteolysis IDA
IDA: 通过直接分析推断
18355449 GOA
involved in membrane protein ectodomain proteolysis IDA
IDA: 通过直接分析推断
12714508 GOA
involved in membrane protein ectodomain proteolysis IMP
IMP: 通过突变表型推断
17965014 GOA
involved in monocyte activation IMP
IMP: 通过突变表型推断
11831872 GOA
involved in negative regulation of cell adhesion IDA
IDA: 通过直接分析推断
12714508 GOA
acts upstream of or within negative regulation of gene expression IMP
IMP: 通过突变表型推断
24530397 GOA
involved in pore complex assembly IMP
IMP: 通过突变表型推断
30463011 GOA
involved in positive regulation of T cell chemotaxis IMP
IMP: 通过突变表型推断
18373975 GOA
involved in positive regulation of cell growth IMP
IMP: 通过突变表型推断
18373975 GOA
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
18373975 GOA
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
18373975 GOA
involved in response to tumor necrosis factor IDA
IDA: 通过直接分析推断
11831872 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
12475894 GOA
located in Golgi-associated vesicle IDA
IDA: 通过直接分析推断
12475894 GOA
located in cell surface IDA
IDA: 通过直接分析推断
12475894 GOA
located in perinuclear endoplasmic reticulum IDA
IDA: 通过直接分析推断
23091066 GOA
located in plasma membrane IMP
IMP: 通过突变表型推断
20624979 GOA
part of pore complex IMP
IMP: 通过突变表型推断
30463011 GOA
located in synaptic membrane IDA
IDA: 通过直接分析推断
23676497 GOA
located in tetraspanin-enriched microdomain IDA
IDA: 通过直接分析推断
23035126 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADAM10 蛋白结构

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (43 - 156)

Reprolysin_2

Reprolysin_2: Metallo-peptidase family M12B Reprolysin-like (240 - 445)

Disintegrin

Disintegrin: Disintegrin (466 - 547)

  • 0
  • 200
  • 400
  • 600
  • 748 a.a.
蛋白主名 其他名称

disintegrin and metalloproteinase domain-containing protein 10

a disintegrin and metalloprotease domain 10

kuzbanian protein homolog

mammalian disintegrin-metalloprotease

ADAM10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ADAM10 O14672 TSPAN33 Homo sapiens Q86UF1
Anti Tag CoIP
23091066
Intra ADAM10 O14672 TSPAN33 Homo sapiens Q86UF1
IF
23091066
Intra ADAM10 O14672 LCK Homo sapiens P06239
Pull Down
25036101
Intra ADAM10 O14672 LCK Homo sapiens P06239
Phage Display
25036101
Intra ADAM10 O14672 LCK Homo sapiens P06239
Anti Bait CoIP
25036101
Intra ADAM10 O14672 TSPAN5 Homo sapiens P62079
Anti Bait CoIP
23091066
Intra ADAM10 O14672 TSPAN5 Homo sapiens P62079
Anti Tag CoIP
23091066
Intra ADAM10 O14672 TSPAN5 Homo sapiens P62079
Anti Bait CoIP
26686862
Intra ADAM10 O14672 TSPAN5 Homo sapiens P62079
IF
23091066
Intra ADAM10 O14672 BACE1 Homo sapiens P56817
BiFC
30538620
Intra ADAM10 O14672 BACE1 Homo sapiens P56817
FRET
30538620
Intra ADAM10 O14672 GRAP Homo sapiens Q13588
Pull Down
25036101
Intra ADAM10 O14672 SNX18 Homo sapiens Q96RF0
Pull Down
25036101
Intra ADAM10 O14672 SNX18 Homo sapiens Q96RF0
Phage Display
25036101
Intra ADAM10 O14672 HCK Homo sapiens P08631
Pull Down
25036101
Intra ADAM10 O14672 ABL1 Homo sapiens P00519
Pull Down
25036101
Intra ADAM10 O14672 ABL1 Homo sapiens P00519
Phage Display
25036101
Intra ADAM10 O14672 GRB2 Homo sapiens P62993
Phage Display
25036101
Intra ADAM10 O14672 GRB2 Homo sapiens P62993
Anti Bait CoIP
25036101
Intra ADAM10 O14672 GRB2 Homo sapiens P62993
Pull Down
25036101
Intra ADAM10 O14672 CD9 Homo sapiens P21926
Anti Bait CoIP
26686862
Intra ADAM10 O14672 CD9 Homo sapiens P21926
Anti Bait CoIP
23091066
Intra ADAM10 O14672 FYN Homo sapiens P06241
Pull Down
25036101
Intra ADAM10 O14672 YES1 Homo sapiens P07947
Pull Down
25036101
Intra ADAM10 O14672 SRC Homo sapiens P12931
Phage Display
25036101
Intra ADAM10 O14672 SRC Homo sapiens P12931
Pull Down
25036101
Intra ADAM10 O14672 TSPAN14 Homo sapiens Q8NG11
Anti Tag CoIP
23091066
Intra ADAM10 O14672 TSPAN14 Homo sapiens Q8NG11
Anti Bait CoIP
26686862
Intra ADAM10 O14672 TSPAN14 Homo sapiens Q8NG11
IF
23091066
Intra ADAM10 O14672 TSPAN14 Homo sapiens Q8NG11
Anti Bait CoIP
23091066
Intra ADAM10 O14672 SH3GL1 Homo sapiens Q99961
Phage Display
25036101
Intra ADAM10 O14672 SH3GL1 Homo sapiens Q99961
Pull Down
25036101
Intra ADAM10 O14672 CD81 Homo sapiens P60033
Anti Bait CoIP
26686862
Intra ADAM10 O14672 CD81 Homo sapiens P60033
Anti Bait CoIP
23091066
Intra ADAM10 O14672 PACSIN1 Homo sapiens Q9BY11
Pull Down
25036101
Intra ADAM10 O14672 TSPAN15 Homo sapiens O95858
Anti Bait CoIP
23091066
Intra ADAM10 O14672 TSPAN15 Homo sapiens O95858
Anti Bait CoIP
26686862
Intra ADAM10 O14672 TSPAN15 Homo sapiens O95858
Anti Tag CoIP
23091066
Intra ADAM10 O14672 TSPAN15 Homo sapiens O95858
IF
23091066
Intra ADAM10 O14672 GRAP2 Homo sapiens O75791
Pull Down
25036101
Intra ADAM10 O14672 GRAP2 Homo sapiens O75791
Phage Display
25036101
Intra ADAM10 O14672 PACSIN2 Homo sapiens Q9UNF0
Pull Down
25036101
Intra ADAM10 O14672 APP Homo sapiens P05067
Y2H Array
32814053
Intra ADAM10 O14672 APP Homo sapiens P05067
FRET
30538620
Intra ADAM10 O14672 APP Homo sapiens P05067
Y2H Pooling
32814053
Intra ADAM10 O14672 APP Homo sapiens P05067
Validated Y2H
32814053
Intra ADAM10 O14672 PACSIN3 Homo sapiens Q9UKS6
Pull Down
25036101
Intra ADAM10 O14672 PACSIN3 Homo sapiens Q9UKS6
Phage Display
25036101
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Leech Infestation

Hirudiniasis

Leeches
Scrapie
Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21
Alzheimer Disease 18

AD18

Alzheimer'S Disease 18

Alzheimer Disease 18, Late-Onset

Alzheimer Disease 18, Susceptibility To

Alzheimer'S Disease 18, Late Onset

Alzheimer Disease 18 Late-Onset

Alzheimer Disease, Susceptibility To, Type 18
Dowling-Degos Disease 1

Reticular Pigment Anomaly Of Flexures

DDD1

Ddd

Dowling-Degos Disease

Hyperpigmentation
Reticulate Acropigmentation Of Kitamura

RAK

Acropigmentatio Reticularis

Reticulate Pigmentation Of Kitamura

Rpk

Kitamura Reticulate Acropigmentation

Rapk
Purulent Acute Otitis Media

Acute Suppurative Otitis Media

Acute Or Subacute Suppurative Otitis Media

Acute Or Subacute Purulent Otitis Media
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder
Purpura Fulminans

Purpura Gangrenosa
Cerebral Amyloid Angiopathy, Itm2b-Related, 1

Dementia, Familial British

Fbd

Presenile Dementia With Spastic Ataxia

Familial British Dementia

Abri Amyloidosis

Cerebral Amyloid Angiopathy, British Type

Itm2b-Related Cerebral Amyloid Angiopathy 1

Familial Dementia, British Type

Cerebral Amyloid Angiopathy, Itm2b-Related 1

CAA-ITM2B1

Cerebral Amyloid Angiopathy British Type

Dementia, Familial, British
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Osteoarthritis

Osteoarthrosis

Degenerative Joint Disease

Hypertrophic Arthritis

Arthropathy

Degenerative Polyarthritis

Degenerative Arthritis

Osteoarthrosis And Allied Disorder

Arthritis, Degenerative

Oa

Osteoarthritis Deformans

Osteoarthrosis Deformans

Kashin-Beck Disease
Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-10293 Aderbasib Inhibitor 99.44% Phase 2
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-115670 GW280264X Inhibitor 98.28% 否
HY-110397 KP-457 Inhibitor 99.18% 否
HY-108675 PPNDS tetrasodium Inhibitor 96.39% 否
HY-120852 JG26 Inhibitor 98.01% 否
HY-P3722A Mca-PLAQAV-Dpa-RSSSR-NH2 TFA 99.21% 否
HY-P3722 Mca-PLAQAV-Dpa-RSSSR-NH2 / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ADAM10 MGD MGI:109548
Canis familiaris ADAM10 VGNC VGNC:59103
Felis catus ADAM10 VGNC VGNC:59573
Bos taurus ADAM10 VGNC VGNC:25604
Rattus norvegicus ADAM10 RGD RGD:2032
Macaca mulatta ADAM10 VGNC VGNC:69465
Others ADAM10 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z