2. Gene
  3. PACSIN3 - protein kinase C and casein kinase substrate in neurons 3 Gene

PACSIN3 - protein kinase C and casein kinase substrate in neurons 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经元中的蛋白激酶 C 和酪蛋白激酶底物 3

种属: Homo sapiens

同用名: SDPIII

基因 ID: 29763 | 基因类型: protein coding

关于 PACSIN3

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,177,522-47,186,434 (from NCBI)

This gene has 11 transcripts (splice variants), 206 orthologues and 2 paralogues. Broad expression in heart (RPKM 38.4), adrenal (RPKM 19.1) and 17 other tissues.

功能概要

该基因是神经元家族中蛋白激酶 C 和酪蛋白激酶底物的成员。编码的蛋白质参与连接肌动蛋白细胞骨架和囊泡形成。可变剪接导致多个转录本变体。[RefSeq 提供，2010 年 5 月]

This gene is a member of the protein kinase C and Casein Kinase substrate in neurons family. The encoded protein is involved in linking the actin Cytoskeleton with vesicle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

PACSIN3 基因产物(3)

mRNA Protein Name
NM_001184974.2 NP_001171903.1 protein kinase C and casein kinase substrate in neurons protein 3
NM_001184975.2 NP_001171904.1 protein kinase C and casein kinase substrate in neurons protein 3
NM_016223.5 NP_057307.2 protein kinase C and casein kinase substrate in neurons protein 3
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables lipid binding IDA
IDA: 通过直接分析推断
23236520 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10531379 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in plasma membrane tubulation IDA
IDA: 通过直接分析推断
23236520 GOA
involved in positive regulation of membrane protein ectodomain proteolysis IMP
IMP: 通过突变表型推断
15280379 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PACSIN3 蛋白结构

FCH

FCH: Fes/CIP4, and EFC/F-BAR homology domain (15 - 102)

SH3_9

SH3_9: Variant SH3 domain (370 - 420)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 424 a.a.
蛋白主名 其他名称

protein kinase C and casein kinase substrate in neurons protein 3

SH3 domain-containing protein 6511

PACSIN3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PACSIN3 Q9UKS6 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
Intra PACSIN3 Q9UKS6 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
Intra PACSIN3 Q9UKS6 SOS1 Homo sapiens Q07889
CoIP
14679214
Intra PACSIN3 Q9UKS6 SOS1 Homo sapiens Q07889
Pull Down
14679214
Intra PACSIN3 Q9UKS6 SOS2 Homo sapiens Q07890
Pull Down
14679214
Intra PACSIN3 Q9UKS6 SOS2 Homo sapiens Q07890
CoIP
14679214
Intra PACSIN3 Q9UKS6 LGALS13 Homo sapiens Q9UHV8
Y2H Prey Pooling
25416956
Intra PACSIN3 Q9UKS6 LGALS13 Homo sapiens Q9UHV8
Validated Y2H
25416956
Intra PACSIN3 Q9UKS6 FASLG Homo sapiens P48023
Anti Bait CoIP
16318909
Intra PACSIN3 Q9UKS6 FASLG Homo sapiens P48023
Pull Down
16318909
Intra PACSIN3 Q9UKS6 FASLG Homo sapiens P48023
Anti Tag CoIP
16318909
Intra PACSIN3 Q9UKS6 PACSIN1 Homo sapiens Q9BY11
Validated Y2H
25416956
Intra PACSIN3 Q9UKS6 PACSIN1 Homo sapiens Q9BY11
Y2H Prey Pooling
32296183
Intra PACSIN3 Q9UKS6 PACSIN1 Homo sapiens Q9BY11
Y2H Array
32296183
Intra PACSIN3 Q9UKS6 PACSIN2 Homo sapiens Q9UNF0
Validated Y2H
32296183
Intra PACSIN3 Q9UKS6 PACSIN2 Homo sapiens Q9UNF0
Anti Tag CoIP
35271311
Intra PACSIN3 Q9UKS6 PACSIN2 Homo sapiens Q9UNF0
Anti Tag CoIP
33961781
Intra PACSIN3 Q9UKS6 ADAM15 Homo sapiens Q13444
Pull Down
10531379
Intra PACSIN3 Q9UKS6 ADAM9 Homo sapiens Q13443
Y2H
10531379
Intra PACSIN3 Q9UKS6 ADAM9 Homo sapiens Q13443
Pull Down
10531379
Intra PACSIN3 Q9UKS6 WASL Homo sapiens O00401
Y2H Prey Pooling
32296183
Intra PACSIN3 Q9UKS6 WASL Homo sapiens O00401
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Scapuloperoneal Spinal Muscular Atrophy

SPSMA

Amyotrophy, Neurogenic Scapuloperoneal, New England Type

Neurogenic Scapuloperoneal Amyotrophy, New England Type

Scapuloperoneal Neuronopathy

Spinal Muscular Atrophy, Scapuloperoneal

Amyotrophy Neurogenic Scapuloperoneal New England Type

Muscular Atrophy, Spinal

Scapuloperoneal Form Of Spinal Muscular Atrophy
Metatropic Dysplasia

Metatropic Dwarfism

MTD

Metatropic Dysplasia Type 1

Metatropic Dysplasia, Nonlethal Dominant
Spondylometaphyseal Dysplasia, Kozlowski Type

Spondylometaphyseal Dysplasia Kozlowski Type

Jequier Kozlowski Skeletal Dysplasia

Smd Kozlowski Type

SMDK

Dysmorphism Arthrogryposis Skeletal Maturation Advanced

Jequier-Kozlowski Syndrome

Skeletal Dysplasia Jequier-Kozlowski Type

Smd, Kozlowski Type
Parastremmatic Dwarfism

Parastremmatic Dysplasia

PSTD

Dwarfism, Parastremmatic
Hereditary Motor And Sensory Neuropathy, Type Iic

CMT2C

Charcot-Marie-Tooth Disease Axonal Type 2c

HMSN2C

Hmsn Iic

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2c

Charcot-Marie-Tooth Neuropathy Type 2c

Hereditary Motor And Sensory Neuropathy Type Iic

Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2c

Charcot-Marie-Tooth Neuropathy, Type 2c

Autosomal Cominant Axonal Charcot-Marie-Tooth Disease Type 2c

Charcot-Marie-Tooth Disease 2c

Charcot-Marie-Tooth Disease Axonal Autosomal Dominant 2c

Charcot-Marie-Tooth Disease, Type 2c
Brachyolmia

Brachyrachia
Spondyloepiphyseal Dysplasia, Maroteaux Type

Spondyloepiphyseal Dysplasia Maroteaux Type

Pseudo-Morquio Syndrome Type 2

Sed, Maroteaux Type

Brachyolmia Type 2

Pseudo-Morquio Syndrome, Type 2

Spondyloepiphyseal Dysplasia Of Maroteaux

Brachyolmia Maroteaux Type

SEDM

Sed Maroteaux Type

Dysplasia, Spondyloepiphyseal, Maroteaux Type
Motor Peripheral Neuropathy

Motor Neuritis

Peripheral Motor Neuropathy

Hereditary Motor And Sensory Neuropathy

Hsmn

Hsmn - Hereditary Sensory And Motor Neuropathy

Neuropathic Muscular Atrophy

Hereditary Sensory And Motor Neuropathy

Hereditary Motor And Sensory Neuropathies
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09959 PACSIN3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PACSIN3 VGNC VGNC:75746
Felis catus PACSIN3 VGNC VGNC:68683
Rattus norvegicus PACSIN3 RGD RGD:1307327
Bos taurus PACSIN3 VGNC VGNC:32544
Canis familiaris PACSIN3 VGNC VGNC:44233
Mus musculus PACSIN3 MGD MGI:1891410
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