1. Gene
  2. WASL - WASP like actin nucleation promoting factor Gene

WASL - WASP like actin nucleation promoting factor Gene

中文名称:WASP 样肌动蛋白成核促进因子

种属: Homo sapiens

同用名: NWASP; WASPB; N-WASP

基因 ID: 8976 | 基因类型: protein coding

关于 WASL

Cytogenetic location: 7q31.32 Genomic coordinates (GRCh38): 7:123,681,943-123,749,003 (from NCBI)

This gene has 1 transcript (splice variant), 256 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 25.7), thyroid (RPKM 23.4) and 25 other tissues.

功能概要

该基因编码 Wiskott-Aldrich 综合征 (WAS) 蛋白家族的成员。 Wiskott-Aldrich 综合征蛋白具有相似的结构域,并与多种信号分子结合以改变肌动蛋白细胞骨架。编码的蛋白质在神经组织中高度表达,并与参与细胞骨架组织的几种蛋白质相互作用,包括细胞分裂控制蛋白 42 (CDC42) 和肌动蛋白相关蛋白 2/3 (ARP2/3) 复合物。编码的蛋白质可能参与长肌动蛋白微刺的形成和神经突延伸。[RefSeq 提供,2013 年 7 月]

This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin Cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013]

WASL 基因产物(1)

mRNA Protein Name
NM_003941.4 NP_003932.3 actin nucleation-promoting factor WASL
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11231575 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin filament polymerization IDA
IDA: 通过直接分析推断
16767080 GOA
involved in negative regulation of lymphocyte migration IMP
IMP: 通过突变表型推断
22585739 GOA
involved in negative regulation of membrane tubulation IDA
IDA: 通过直接分析推断
18388313 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16767080 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
18388313 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16767080 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

WASL 蛋白结构

WH1

WH1: WH1 domain (32 - 136)

PBD

PBD: P21-Rho-binding domain (202 - 260)

WH2

WH2: WH2 motif (404 - 427)

WH2

WH2: WH2 motif (431 - 450)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
蛋白主名 其他名称

actin nucleation-promoting factor WASL

Wiskott-Aldrich syndrome like

WASL 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
WASL O00401 ABI2 Homo sapiens Q9NYB9-2 32296183
种属内
WASL O00401 ARHGAP12 Homo sapiens Q8IWW6-4 32296183
种属内
WASL O00401 SORBS2 Homo sapiens O94875-10 32296183
种属内
WASL O00401 SORBS3 Homo sapiens O60504-2 18662323
种属内
WASL O00401 UBASH3B Homo sapiens Q8TF42 32296183
种属内
WASL O00401 PTK6 Homo sapiens Q13882 25416956
种属内
WASL O00401 PTK6 Homo sapiens Q13882 25416956
种属内
WASL O00401 NCK1 Homo sapiens P16333-1 16595635
种属间
WASL O00401 espF(U) Escherichia coli O157:H7 Q8X482 15296718
种属间
WASL O00401 espF(U) Escherichia coli O157:H7 Q8X482
IF
15296718
种属内
WASL O00401 WIPF2 Homo sapiens Q8TF74 33961781
种属内
WASL O00401 WIPF2 Homo sapiens Q8TF74 28514442
种属内
WASL O00401 WIPF2 Homo sapiens Q8TF74 32296183
种属内
WASL O00401 WIPF2 Homo sapiens Q8TF74 35271311
种属内
WASL O00401 WIPF2 Homo sapiens Q8TF74 23414517
种属内
WASL O00401 WIPF1 Homo sapiens O43516 35271311
种属内
WASL O00401 WIPF1 Homo sapiens O43516 16582881
种属内
WASL O00401 WIPF1 Homo sapiens O43516 33961781
种属内
WASL O00401 WIPF1 Homo sapiens O43516
Y2H
11331876
种属内
WASL O00401 WIPF1 Homo sapiens O43516 25416956
种属内
WASL O00401 WIPF1 Homo sapiens O43516 28514442
种属内
WASL O00401 WIPF1 Homo sapiens O43516 23414517
种属内
WASL O00401 ARPC3 Homo sapiens O15145 32296183
种属内
WASL O00401 ARPC3 Homo sapiens O15145 25416956
种属内
WASL O00401 ARPC3 Homo sapiens O15145 25416956
种属内
WASL O00401 ARPC4 Homo sapiens P59998 32296183
种属内
WASL O00401 CIB1 Homo sapiens Q99828
Y2H
16582881
种属内
WASL O00401 CIB1 Homo sapiens Q99828 16582881
种属内
WASL O00401 RNF8 Homo sapiens O76064 31515488
种属内
WASL O00401 RNF8 Homo sapiens O76064 25416956
种属内
WASL O00401 RNF8 Homo sapiens O76064 32296183
种属内
WASL O00401 RNF8 Homo sapiens O76064 25416956
种属内
WASL O00401 RNF8 Homo sapiens O76064 25416956
种属内
WASL O00401 NCK1 Homo sapiens P16333 17474147
种属内
WASL O00401 WIPF3 Homo sapiens A6NGB9 33961781
种属内
WASL O00401 WIPF3 Homo sapiens A6NGB9 28514442
种属内
WASL O00401 WIPF3 Homo sapiens A6NGB9 35271311
种属内
WASL O00401 GRB2 Homo sapiens P62993 20936779
种属内
WASL O00401 GRB2 Homo sapiens P62993 25416956
种属内
WASL O00401 RHOJ Homo sapiens Q9H4E5 32296183
种属内
WASL O00401 TRIP10 Homo sapiens Q15642-2 32296183
种属内
WASL O00401 NCK2 Homo sapiens O43639 25416956
种属内
WASL O00401 PAK4 Homo sapiens O96013 29100370
种属内
WASL O00401 SDCBP Homo sapiens O00560 25416956
种属内
WASL O00401 SDCBP Homo sapiens O00560 25416956
种属内
WASL O00401 SDCBP Homo sapiens O00560 32296183
种属内
WASL O00401 UBASH3A Homo sapiens P57075-2 32296183
种属内
WASL O00401 PACSIN2 Homo sapiens Q9UNF0 32296183
种属内
WASL O00401 PACSIN3 Homo sapiens Q9UKS6 32296183
种属内
WASL O00401 CDC42 Homo sapiens P60953 15834156
种属间
WASL O00401 Fnbp1 Rattus norvegicus Q8R511 14732713
种属间
WASL O00401 ACTR3 Bos taurus P61157 16253999
种属间
WASL O00401 ACTR3 Bos taurus P61157 11231575
种属间
WASL O00401 ACTR3 Bos taurus P61157 12732638
种属间
WASL O00401 ACTA1 Oryctolagus cuniculus P68135 11231575
种属间: 跨种属相互作用 种属内: 同种属相互作用

WASL 抗体

目录号 产品名 应用 反应物种
HY-P81720 N WASP Antibody (YA1465) WB, IHC-F, IHC-P, ICC/IF Human, Mouse

关联疾病

疾病名称 别名
Wiskott-Aldrich Syndrome

WAS

Eczema-Thrombocytopenia-Immunodeficiency Syndrome

Immunodeficiency 2

Aldrich Syndrome

Imd2

Wiskott-Aldrich Syndrome 1

Was1

Wiskott Syndrome

Wiskott Aldrich Syndrome

Eczema Thrombocytopenia Immunodeficiency Syndrome

Imd 2

Buruli Ulcer

Buruli Ulcer, Susceptibility To

Buruli Ulcer Disease

Mycobacterium Ulcerans

Mycobacterium Ulcerans, Susceptibility To

Bairnsdale Ulcer

Daintree Ulcer

Mossman Ulcer

Searl Ulcer

Searle'S Ulcer

Bud

Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 2

Aoa2

Ataxia With Oculomotor Apraxia Type 2

Scar1

SCAN2

Ataxia-Oculomotor Apraxia 2

Ataxia-Ocular Apraxia 2

Ataxia-Oculomotor Apraxia Type 2

Scan 2

Spinocerebellar Ataxia With Axonal Neuropathy Type 2

Spinocerebellar Ataxia, Autosomal Recessive 1, Formerly

Scar1, Formerly

Autosomal Recessive Spinocerebellar Ataxia-1

Spinocerebellar Ataxia, Autosomal Recessive, 1

Ataxia-Ocular Apraxia-2

Spinocerebellar Ataxia, Autosomal Recessive 1

Vaccinia
Myopathy, Centronuclear, 2

Myopathy, Centronuclear, Autosomal Recessive

Autosomal Recessive Centronuclear Myopathy

CNM2

Centronuclear Myopathy 2

Ar-Cnm

Myotubular Myopathy, Autosomal Recessive

Autosomal Recessive Myotubular Myopathy

Centronuclear Myopathy Autosomal Recessive

Myopathy, Centronuclear, Type 2

Lower Lip Cancer
Aarskog-Scott Syndrome

Aarskog Syndrome

Faciogenital Dysplasia

Faciodigitogenital Syndrome

AAS

Fgdy

X-Linked Aarskog Syndrome

Intellectual Developmental Disorder, X-Linked, Syndromic 16

Aarskog Syndrome, X-Linked

Intellectual Developmental Disorder, X-Linked Syndromic 16

Greig'S Syndrome

Aarskog Scott Syndrome

Aarskog Disease

Scott Aarskog Syndrome

Facio-Digito-Genital Dysplasia

Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder

Aarskog-Scott Syndrome ) Syndrome

Frank-Ter Haar Syndrome

Ter Haar Syndrome

Borrone Dermatocardioskeletal Syndrome

FTHS

Autosomal Recessive Melnick-Needles Syndrome

Borrone Di Rocco Crovato Syndrome

Megalocornea, Multiple Skeletal Anomalies, And Developmental Delay

Melnick-Needles Syndrome, Autosomal Recessive, Formerly

Frank Ter Haar Syndrome

Neutropenia, Severe Congenital, X-Linked

X-Linked Severe Congenital Neutropenia

XLN

SCNX

Severe Congenital Neutropenia X-Linked

Neutropenia, Congenital, Severe, X-Linked

Shigellosis

Dysentery, Bacillary

Bacillary Dysentery

Shigella Boydii Infectious Disease

Shigella Flexneri Infectious Disease

Shigella Gastroenteritis

Shigella Sonnei Infectious Disease

Shigella Infections

Otopalatodigital Syndrome Spectrum Disorder

Opd Spectrum Disorder

Opsd

Fronto-Otopalatodigital Osteodysplasia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus WASL RGD RGD:735144
Mus musculus WASL MGD MGI:1920428
Canis familiaris WASL VGNC VGNC:58887
Bos taurus WASL VGNC VGNC:56336
Macaca mulatta WASL VGNC VGNC:78783
Felis catus WASL VGNC VGNC:67007