ARPC3 - actin related protein 2/3 complex subunit 3 Gene

中文名称：肌动蛋白相关蛋白 2/3 复合亚基 3

种属: Homo sapiens

同用名: ARC21; p21-Arc

基因 ID: 10094 | 基因类型: protein coding

关于 ARPC3

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:110,434,823-110,450,337 (from NCBI)

This gene has 9 transcripts (splice variants) and 222 orthologues. Ubiquitous expression in lymph node (RPKM 232.8), bone marrow (RPKM 231.9) and 25 other tissues.

功能概要

该基因编码人类 Arp2/3 蛋白复合物的七个亚基之一。 Arp2/3 蛋白复合物在进化过程中得以保存，并与细胞中肌动蛋白聚合的控制有关。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2013 年 12 月]

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

ARPC3 基因产物(2)

mRNA	Protein	Name
NM_001287222.2	NP_001274151.1	actin-related protein 2/3 complex subunit 3 isoform 2
NM_001278556.2	NP_001265485.1	actin-related protein 2/3 complex subunit 3 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
contributes to actin filament binding	IDA IDA: 通过直接分析推断	11741539	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11162547	GOA
enables structural constituent of cytoskeleton	IDA IDA: 通过直接分析推断	11741539	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Arp2/3 complex-mediated actin nucleation	IDA IDA: 通过直接分析推断	11741539	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Arp2/3 protein complex	IDA IDA: 通过直接分析推断	11741539	GOA
located in lamellipodium	IDA IDA: 通过直接分析推断	9230079	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARPC3 蛋白结构

P21-Arc

0
100
178 a.a.

蛋白主名

其他名称

actin-related protein 2/3 complex subunit 3

ARP2/3 protein complex subunit p21	actin related protein 2/3 complex, subunit 3, 21kDa
arp2/3 complex 21 kDa subunit

ARPC3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	ARPC3	O15145	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	ARPC3	O15145	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	ARPC3	O15145	DUSP29	Homo sapiens	Q68J44	Validated Y2H	32296183
Intra	ARPC3	O15145	DUSP29	Homo sapiens	Q68J44	Y2H Array	32296183
Intra	ARPC3	O15145	DUSP29	Homo sapiens	Q68J44	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	TARS3	Homo sapiens	A2RTX5	Y2H Array	32296183
Intra	ARPC3	O15145	TARS3	Homo sapiens	A2RTX5	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	RBBP8NL	Homo sapiens	Q8NC74	Y2H Array	32296183
Intra	ARPC3	O15145	RBBP8NL	Homo sapiens	Q8NC74	Validated Y2H	32296183
Intra	ARPC3	O15145	RBBP8NL	Homo sapiens	Q8NC74	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	POU2F1	Homo sapiens	P14859-6	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	POU2F1	Homo sapiens	P14859-6	Validated Y2H	32296183
Intra	ARPC3	O15145	POU2F1	Homo sapiens	P14859-6	Y2H Array	32296183
Intra	ARPC3	O15145	SYBU	Homo sapiens	Q9NX95-5	Validated Y2H	32296183
Intra	ARPC3	O15145	SYBU	Homo sapiens	Q9NX95-5	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	SYBU	Homo sapiens	Q9NX95-5	Y2H Array	32296183
Intra	ARPC3	O15145	LATS1	Homo sapiens	O95835-2	Y2H Array	32296183
Intra	ARPC3	O15145	LATS1	Homo sapiens	O95835-2	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	LATS1	Homo sapiens	O95835-2	Validated Y2H	32296183
Cross	ARPC3	O15145	N	SARS-CoV-2	P0DTC9	Y2H Array	36217030
Intra	ARPC3	O15145	CCR10	Homo sapiens	P46092	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	CCR10	Homo sapiens	P46092	Validated Y2H	32296183
Intra	ARPC3	O15145	CCR10	Homo sapiens	P46092	Y2H Array	32296183
Intra	ARPC3	O15145	ARPC4	Homo sapiens	P59998	Anti Tag CoIP	33961781
Intra	ARPC3	O15145	ARPC4	Homo sapiens	P59998	Anti Tag CoIP	35271311
Intra	ARPC3	O15145	ARPC4	Homo sapiens	P59998	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	ARPC4	Homo sapiens	P59998	Validated Y2H	32296183
Intra	ARPC3	O15145	ARPC4	Homo sapiens	P59998	Y2H Array	32296183
Intra	ARPC3	O15145	ZNF576	Homo sapiens	Q9H609	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	ZNF576	Homo sapiens	Q9H609	Validated Y2H	32296183
Intra	ARPC3	O15145	ZNF576	Homo sapiens	Q9H609	Y2H Array	32296183
Intra	ARPC3	O15145	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	ARPC3	O15145	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	ARPC3	O15145	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	ARPC3	O15145	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	ARPC3	O15145	NRIP1	Homo sapiens	P48552	Validated Y2H	25416956
Intra	ARPC3	O15145	FAM9A	Homo sapiens	Q8IZU1	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	FAM9A	Homo sapiens	Q8IZU1	Validated Y2H	32296183
Intra	ARPC3	O15145	FAM9A	Homo sapiens	Q8IZU1	Y2H Array	32296183
Intra	ARPC3	O15145	HOXA3	Homo sapiens	O43365	Y2H Prey Pooling	25416956
Intra	ARPC3	O15145	HOXA3	Homo sapiens	O43365	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	HOXA3	Homo sapiens	O43365	Validated Y2H	32296183
Intra	ARPC3	O15145	HOXA3	Homo sapiens	O43365	Y2H Array	32296183
Intra	ARPC3	O15145	WASL	Homo sapiens	O00401	Validated Y2H	25416956
Intra	ARPC3	O15145	WASL	Homo sapiens	O00401	Y2H Array	32296183
Intra	ARPC3	O15145	WASL	Homo sapiens	O00401	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Porokeratosis

Disseminated Superficial Actinic Porokeratosis	Dsap
Porokeratosis Of Mibelli	Porokeratosis, Disseminated Superficial Actinic
Porokeratosis, Disseminated Superficial Actinic, 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01018	ARPC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01019	Arpc3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01020	Arpc3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	ARPC3	VGNC	VGNC:99890
Rattus norvegicus	ARPC3	RGD	RGD:1311985
Bos taurus	ARPC3	VGNC	VGNC:53890
Mus musculus	ARPC3	MGD	MGI:1928375

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