2. Gene
  3. HOXA3 - homeobox A3 Gene

HOXA3 - homeobox A3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：同源框 A3

种属: Homo sapiens

同用名: HOX1; HOX1E

基因 ID: 3200 | 基因类型: protein coding

关于 HOXA3

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:27,107,010-27,152,583 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and 42 paralogues. Broad expression in kidney (RPKM 1.8), fat (RPKM 1.4) and 17 other tissues.

功能概要

在脊椎动物中，编码称为同源盒基因的转录因子类的基因位于四个独立染色体上名为 A、B、C 和 D 的簇中。这些蛋白质的表达在胚胎发育过程中受到时空调控。该基因是 7 号染色体 A 簇的一部分，编码 DNA 结合转录因子，可调节基因表达、形态发生和分化。已发现该基因编码两种不同亚型的三种转录变体。[RefSeq 提供，2008 年 7 月]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

HOXA3 基因产物(14)

mRNA Protein Name
NM_001384335.1 NP_001371264.1 homeobox protein Hox-A3
NM_001384336.1 NP_001371265.1 homeobox protein Hox-A3
NM_001384337.1 NP_001371266.1 homeobox protein Hox-A3
NM_001384338.1 NP_001371267.1 homeobox protein Hox-A3
NM_001384339.1 NP_001371268.1 homeobox protein Hox-A3
NM_001384340.1 NP_001371269.1 homeobox protein Hox-A3
NM_001384341.1 NP_001371270.1 homeobox protein Hox-A3
NM_001384342.1 NP_001371271.1 homeobox protein Hox-A3
NM_001384343.1 NP_001371272.1 homeobox protein Hox-A3
NM_001384344.1 NP_001371273.1 homeobox protein Hox-A3
NM_001384345.1 NP_001371274.1 homeobox protein Hox-A3
NM_001384346.1 NP_001371275.1 homeobox protein Hox-A3
NM_030661.5 NP_109377.1 homeobox protein Hox-A3
NM_153631.3 NP_705895.1 homeobox protein Hox-A3
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21516116 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in angiogenesis IEP
IEP: 通过表达模式推断
17972163 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HOXA3 蛋白结构

Homeobox

Homeobox: Homeobox domain (192 - 248)

DUF4074

DUF4074: Domain of unknown function (DUF4074) (376 - 441)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 443 a.a.
蛋白主名 其他名称

homeobox protein Hox-A3

Hox-1.5-like protein

HOXA3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra HOXA3 O43365 BDNF Homo sapiens P23560-2
Y2H Pooling
32814053
Intra HOXA3 O43365 BDNF Homo sapiens P23560-2
Validated Y2H
32814053
Intra HOXA3 O43365 BDNF Homo sapiens P23560-2
Y2H Array
32814053
Intra HOXA3 O43365 ARPC3 Homo sapiens O15145
Validated Y2H
25416956
Intra HOXA3 O43365 ARPC3 Homo sapiens O15145
Y2H Array
25416956
Intra HOXA3 O43365 SEC23B Homo sapiens Q15437
Y2H
21516116
Intra HOXA3 O43365 SEC23B Homo sapiens Q15437
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Penile Cancer

Penis Carcinoma

Carcinoma Of Penis

Penile Neoplasm

Penile Carcinoma

Penile Neoplasms

Malignant Neoplasm Of Penis

Ca Penis

Malignant Neoplasm Of Body Of Penis

Malignant Penile Tumor

Penile Ca
T-Cell Immunodeficiency With Thymic Aplasia

Nezelof Syndrome

T-Lymphocyte Deficiency

TIDTA

Immune Defect Due To Absence Of Thymus

Thymic Aplasia

Nezelof'S Syndrome

Thymic Dysplasia With Normal Immunoglobulins

Thymic Aplasia Syndrome

T-Lymphocyte Immunodeficiency
Ectopic Thymus
Thyroid Malformation
Hand-Foot-Genital Syndrome

Hand-Foot-Uterus Syndrome

Hfgs

Hfg Syndrome

Hfu Syndrome

HFG

Hfu

Hand Foot Uterus Syndrome

Hand Foot Genital Syndrome
Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06298 HOXA3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta HOXA3 VGNC VGNC:73502
Felis catus HOXA3 VGNC VGNC:67619
Mus musculus HOXA3 MGD MGI:96175
Rattus norvegicus HOXA3 RGD RGD:1561431
Bos taurus HOXA3 VGNC VGNC:29911
Canis familiaris HOXA3 VGNC VGNC:41747
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