ARPC4 - actin related protein 2/3 complex subunit 4 Gene

中文名称：肌动蛋白相关蛋白 2/3 复合亚基 4

种属: Homo sapiens

同用名: ARC20; DEVLO; P20-ARC

关于 ARPC4

功能概要

该基因编码人类 Arp2/3 蛋白复合物的七个亚基之一。该复合物控制细胞中的肌动蛋白聚合，并在整个真核生物进化过程中得到保护。该基因编码 p20 亚基，这是肌动蛋白成核和与 F-肌动蛋白高亲和力结合所必需的。可变剪接导致多个转录本变体。该基因与下游微管蛋白酪氨酸连接酶样家族成员 3 (TTLL3) 之间存在自然发生的通读转录，导致融合蛋白的产生。[RefSeq 提供，2010 年 11 月]

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010]