2. Gene
  3. METTL21A - methyltransferase 21A, HSPA lysine Gene

METTL21A - methyltransferase 21A, HSPA lysine Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：甲基转移酶 21A，HSPA 赖氨酸

种属: Homo sapiens

同用名: FAM119A; HCA557b; HSPA-KMT

基因 ID: 151194 | 基因类型: protein coding

关于 METTL21A

Cytogenetic location: 2q33.3 Genomic coordinates (GRCh38): 2:207,580,635-207,626,053 (from NCBI)

This gene has 13 transcripts (splice variants), 203 orthologues and 4 paralogues. Ubiquitous expression in lymph node (RPKM 1.8), spleen (RPKM 1.7) and 25 other tissues.

功能概要

启用 ATPase 绑定活动； HSP70 蛋白结合活性；和蛋白质-赖氨酸 N-甲基转移酶活性。参与肽基-赖氨酸甲基化。部分含蛋白质复合物。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATPase binding activity; HSP70 protein binding activity; and protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine methylation. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

METTL21A 基因产物(26)

mRNA Protein Name
NM_001127395.5 NP_001120867.1 protein N-lysine methyltransferase METTL21A isoform 1
NM_001308021.3 NP_001294950.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001330130.2 NP_001317059.1 protein N-lysine methyltransferase METTL21A isoform 1
NM_001330131.2 NP_001317060.1 protein N-lysine methyltransferase METTL21A isoform 3
NM_001330132.3 NP_001317061.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001330133.3 NP_001317062.1 protein N-lysine methyltransferase METTL21A isoform 3
NM_001330134.2 NP_001317063.1 protein N-lysine methyltransferase METTL21A isoform 1
NM_001330135.2 NP_001317064.1 protein N-lysine methyltransferase METTL21A isoform 3
NM_001330136.3 NP_001317065.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001330137.2 NP_001317066.1 protein N-lysine methyltransferase METTL21A isoform 4
NM_001388427.1 NP_001375356.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001388439.2 NP_001375368.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001393563.1 NP_001380492.1 protein N-lysine methyltransferase METTL21A isoform 5
NM_001393564.1 NP_001380493.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001393565.1 NP_001380494.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001393566.1 NP_001380495.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001393567.1 NP_001380496.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001393568.1 NP_001380497.1 protein N-lysine methyltransferase METTL21A isoform 6
NM_001393569.1 NP_001380498.1 protein N-lysine methyltransferase METTL21A isoform 7
NM_001393570.1 NP_001380499.1 protein N-lysine methyltransferase METTL21A isoform 7
NM_001393571.1 NP_001380500.1 protein N-lysine methyltransferase METTL21A isoform 8
NM_001393572.1 NP_001380501.1 protein N-lysine methyltransferase METTL21A isoform 8
NM_001393573.1 NP_001380502.1 protein N-lysine methyltransferase METTL21A isoform 3
NM_001393574.1 NP_001380503.1 protein N-lysine methyltransferase METTL21A isoform 3
NM_001393575.1 NP_001380504.1 protein N-lysine methyltransferase METTL21A isoform 3
NM_145280.7 NP_660323.3 protein N-lysine methyltransferase METTL21A isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATPase binding IPI
IPI: 通过物理相互作用推断
23921388 GOA
enables Hsp70 protein binding IPI
IPI: 通过物理相互作用推断
23921388 GOA
enables heat shock protein binding IPI
IPI: 通过物理相互作用推断
23349634 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21516116 GOA
enables protein methyltransferase activity IDA
IDA: 通过直接分析推断
23349634 GOA
enables protein-lysine N-methyltransferase activity IDA
IDA: 通过直接分析推断
22948820 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in peptidyl-lysine methylation IDA
IDA: 通过直接分析推断
23921388 GOA
involved in protein methylation IDA
IDA: 通过直接分析推断
22948820 GOA
NOT involved in regulation of ATP-dependent activity IDA
IDA: 通过直接分析推断
23921388 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protein-containing complex IDA
IDA: 通过直接分析推断
23349634 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

METTL21A 蛋白结构

Methyltransf_16

Methyltransf_16: Lysine methyltransferase (27 - 189)

  • 0
  • 100
  • 200
  • 218 a.a.
蛋白主名 其他名称

protein N-lysine methyltransferase METTL21A

HSPA lysine methyltransferase

METTL21A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
METTL21A Q8WXB1 MSRB3 Homo sapiens Q8IXL7-2
Y2H Array
32296183
种属内
METTL21A Q8WXB1 MSRB3 Homo sapiens Q8IXL7-2
Y2H Prey Pooling
32296183
种属内
METTL21A Q8WXB1 LZTS1 Homo sapiens Q9Y250
Validated Y2H
32296183
种属内
METTL21A Q8WXB1 LZTS1 Homo sapiens Q9Y250
Y2H Array
32296183
种属内
METTL21A Q8WXB1 LZTS1 Homo sapiens Q9Y250
Y2H Prey Pooling
32296183
种属内
METTL21A Q8WXB1 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
METTL21A Q8WXB1 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
METTL21A Q8WXB1 MEI4 Homo sapiens A8MW99
Y2H Array
32296183
种属内
METTL21A Q8WXB1 MEI4 Homo sapiens A8MW99
Y2H Prey Pooling
32296183
种属内
METTL21A Q8WXB1 ARPC4 Homo sapiens P59998
Y2H Prey Pooling
32296183
种属内
METTL21A Q8WXB1 ARPC4 Homo sapiens P59998
Y2H Array
32296183
种属内
METTL21A Q8WXB1 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
种属内
METTL21A Q8WXB1 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
种属内
METTL21A Q8WXB1 PFDN5 Homo sapiens Q99471
Validated Y2H
32296183
种属内
METTL21A Q8WXB1 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
种属内
METTL21A Q8WXB1 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
种属内
METTL21A Q8WXB1 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
种属内
METTL21A Q8WXB1 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
种属内
METTL21A Q8WXB1 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
种属内
METTL21A Q8WXB1 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
种属内
METTL21A Q8WXB1 FAM200C Homo sapiens Q8IZ13
Y2H
21516116
种属内
METTL21A Q8WXB1 FAM200C Homo sapiens Q8IZ13
Y2H Array
31515488
种属内
METTL21A Q8WXB1 FAM200C Homo sapiens Q8IZ13
Y2H Prey Pooling
32296183
种属内
METTL21A Q8WXB1 FAM200C Homo sapiens Q8IZ13
Y2H Array
32296183
种属内
METTL21A Q8WXB1 LNX1 Homo sapiens Q8TBB1
Y2H Array
25416956
种属内
METTL21A Q8WXB1 LNX1 Homo sapiens Q8TBB1
Y2H Array
29892012
种属内
METTL21A Q8WXB1 ATRIP Homo sapiens Q8WXE1
Y2H Array
25416956
种属内
METTL21A Q8WXB1 ATRIP Homo sapiens Q8WXE1
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pontocerebellar Hypoplasia, Type 2a

Pontocerebellar Hypoplasia Type 2a

PCH2A

Pch2

Pontocerebellar Hypoplasia With Progressive Cerebral Atrophy

Volendam Neurodegenerative Disease

Pontocerebellar Hypoplasia 2a

Hypoplasia, Pontocerebellar, Type 2a
Malignant Ovarian Cyst
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08360 METTL21A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta METTL21A VGNC VGNC:74625
Mus musculus METTL21A MGD MGI:1914349
Rattus norvegicus METTL21A RGD RGD:7651604
Bos taurus METTL21A VGNC VGNC:31406
Felis catus METTL21A VGNC VGNC:80279
Canis familiaris METTL21A VGNC VGNC:57396
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