LZTS1 - leucine zipper tumor suppressor 1 Gene

中文名称：亮氨酸拉链抑癌基因 1

种属: Homo sapiens

同用名: F37; FEZ1

基因 ID: 11178 | 基因类型: protein coding

关于 LZTS1

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:20,246,165-20,303,963 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 2 paralogues. Broad expression in testis (RPKM 4.1), brain (RPKM 3.1) and 19 other tissues.

功能概要

该基因编码一种在正常组织中普遍表达的肿瘤抑制蛋白。在葡萄膜黑色素瘤中，该蛋白的表达在快速转移和转移性肿瘤细胞中沉默，但在缓慢转移或非转移性肿瘤细胞中表达正常。这种蛋白质可能通过与 CDK1/cyclinB1 复合物相互作用而在细胞周期控制中发挥作用。该基因位于染色体区域 8p22。 8p 臂杂合性缺失 (LOH) 是许多类型癌症的共同特征。[RefSeq 提供，2009 年 11 月]

This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the CDK1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of Cancer. [provided by RefSeq, Nov 2009]

LZTS1 基因产物(2)

mRNA	Protein	Name
NM_001362884.2	NP_001349813.1	leucine zipper putative tumor suppressor 1
NM_021020.5	NP_066300.1	leucine zipper putative tumor suppressor 1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	17349584	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LZTS1 蛋白结构

Fez1

0
100
200
300
400
500
596 a.a.

蛋白主名

其他名称

leucine zipper putative tumor suppressor 1

F37/Esophageal cancer-related gene-coding leucine-zipper motif

LZTS1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	LZTS1	Q9Y250	CEP83	Homo sapiens	Q9Y592-2	Validated Y2H	32296183
Intra	LZTS1	Q9Y250	LSM2	Homo sapiens	Q9Y333	Validated Y2H	32296183
Intra	LZTS1	Q9Y250	CDC25C	Homo sapiens	P30307	Anti Bait CoIP	17349584

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

Ehlers-Danlos Syndrome

Eds	Cutis Hyperelastica
Elastic Skin	Ehlers-Danlos Syndromes
Ed Syndrome	Ehlers Danlos Syndrome
Ehlers Danlos Disease	Eds - [Ehlers-Danlos Syndrome]

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Hypermobility Syndrome

Benign Joint Hypermobility

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07934	LZTS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	LZTS1	RGD	RGD:708565
Bos taurus	LZTS1	VGNC	VGNC:31121
Mus musculus	LZTS1	MGD	MGI:2684762
Macaca mulatta	LZTS1	VGNC	VGNC:74283
Canis familiaris	LZTS1	VGNC	VGNC:42905
Felis catus	LZTS1	VGNC	VGNC:63352

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4